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Title: SU-E-T-07: 4DCT Robust Optimization for Esophageal Cancer Using Intensity Modulated Proton Therapy

Abstract

Purpose: To develop a 4DCT robust optimization method to reduce the dosimetric impact from respiratory motion in intensity modulated proton therapy (IMPT) for esophageal cancer. Methods: Four esophageal cancer patients were selected for this study. The different phases of CT from a set of 4DCT were incorporated into the worst-case dose distribution robust optimization algorithm. 4DCT robust treatment plans were designed and compared with the conventional non-robust plans. Result doses were calculated on the average and maximum inhale/exhale phases of 4DCT. Dose volume histogram (DVH) band graphic and ΔD95%, ΔD98%, ΔD5%, ΔD2% of CTV between different phases were used to evaluate the robustness of the plans. Results: Compare to the IMPT plans optimized using conventional methods, the 4DCT robust IMPT plans can achieve the same quality in nominal cases, while yield a better robustness to breathing motion. The mean ΔD95%, ΔD98%, ΔD5% and ΔD2% of CTV are 6%, 3.2%, 0.9% and 1% for the robustly optimized plans vs. 16.2%, 11.8%, 1.6% and 3.3% from the conventional non-robust plans. Conclusion: A 4DCT robust optimization method was proposed for esophageal cancer using IMPT. We demonstrate that the 4DCT robust optimization can mitigate the dose deviation caused by the diaphragm motion.

Authors:
 [1];  [2]; ; ; ;  [1];  [1];  [2];  [3]
  1. Proton Therapy Center, UT MD Anderson Cancer Center, Houston, TX (United States)
  2. (United States)
  3. Department of Industrial Engineering, University of Houston, Houston, TX (United States)
Publication Date:
OSTI Identifier:
22545142
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ALGORITHMS; COMPUTERIZED TOMOGRAPHY; DESIGN; DIAPHRAGM; ESOPHAGUS; NEOPLASMS; OPTIMIZATION; PATIENTS; PROTON BEAMS; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIOTHERAPY

Citation Formats

Liao, L, Department of Industrial Engineering, University of Houston, Houston, TX, Yu, J, Zhu, X, Li, H, Zhang, X, Li, Y, Varian Medical Systems, Houston, TX, and Lim, G. SU-E-T-07: 4DCT Robust Optimization for Esophageal Cancer Using Intensity Modulated Proton Therapy. United States: N. p., 2015. Web. doi:10.1118/1.4924368.
Liao, L, Department of Industrial Engineering, University of Houston, Houston, TX, Yu, J, Zhu, X, Li, H, Zhang, X, Li, Y, Varian Medical Systems, Houston, TX, & Lim, G. SU-E-T-07: 4DCT Robust Optimization for Esophageal Cancer Using Intensity Modulated Proton Therapy. United States. doi:10.1118/1.4924368.
Liao, L, Department of Industrial Engineering, University of Houston, Houston, TX, Yu, J, Zhu, X, Li, H, Zhang, X, Li, Y, Varian Medical Systems, Houston, TX, and Lim, G. Mon . "SU-E-T-07: 4DCT Robust Optimization for Esophageal Cancer Using Intensity Modulated Proton Therapy". United States. doi:10.1118/1.4924368.
@article{osti_22545142,
title = {SU-E-T-07: 4DCT Robust Optimization for Esophageal Cancer Using Intensity Modulated Proton Therapy},
author = {Liao, L and Department of Industrial Engineering, University of Houston, Houston, TX and Yu, J and Zhu, X and Li, H and Zhang, X and Li, Y and Varian Medical Systems, Houston, TX and Lim, G},
abstractNote = {Purpose: To develop a 4DCT robust optimization method to reduce the dosimetric impact from respiratory motion in intensity modulated proton therapy (IMPT) for esophageal cancer. Methods: Four esophageal cancer patients were selected for this study. The different phases of CT from a set of 4DCT were incorporated into the worst-case dose distribution robust optimization algorithm. 4DCT robust treatment plans were designed and compared with the conventional non-robust plans. Result doses were calculated on the average and maximum inhale/exhale phases of 4DCT. Dose volume histogram (DVH) band graphic and ΔD95%, ΔD98%, ΔD5%, ΔD2% of CTV between different phases were used to evaluate the robustness of the plans. Results: Compare to the IMPT plans optimized using conventional methods, the 4DCT robust IMPT plans can achieve the same quality in nominal cases, while yield a better robustness to breathing motion. The mean ΔD95%, ΔD98%, ΔD5% and ΔD2% of CTV are 6%, 3.2%, 0.9% and 1% for the robustly optimized plans vs. 16.2%, 11.8%, 1.6% and 3.3% from the conventional non-robust plans. Conclusion: A 4DCT robust optimization method was proposed for esophageal cancer using IMPT. We demonstrate that the 4DCT robust optimization can mitigate the dose deviation caused by the diaphragm motion.},
doi = {10.1118/1.4924368},
journal = {Medical Physics},
number = 6,
volume = 42,
place = {United States},
year = {Mon Jun 15 00:00:00 EDT 2015},
month = {Mon Jun 15 00:00:00 EDT 2015}
}