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Title: SU-E-T-02: 90Y Microspheres Dosimetry Calculation with Voxel-S-Value Method: A Simple Use in the Clinic

Abstract

Purpose: To present a simple and feasible method of voxel-S-value (VSV) dosimetry calculation for daily clinical use in radioembolization (RE) with {sup 90}Y microspheres. Dose distributions are obtained and visualized over CT images. Methods: Spatial dose distributions and dose in liver and tumor are calculated for RE patients treated with Sirtex Medical miscrospheres at our center. Data obtained from the previous simulation of treatment were the basis for calculations: Tc-99m maggregated albumin SPECT-CT study in a gammacamera (Infinia, General Electric Healthcare.). Attenuation correction and ordered-subsets expectation maximization (OSEM) algorithm were applied.For VSV calculations, both SPECT and CT were exported from the gammacamera workstation and registered with the radiotherapy treatment planning system (Eclipse, Varian Medical systems). Convolution of activity matrix and local dose deposition kernel (S values) was implemented with an in-house developed software based on Python code. The kernel was downloaded from www.medphys.it. Final dose distribution was evaluated with the free software Dicompyler. Results: Liver mean dose is consistent with Partition method calculations (accepted as a good standard). Tumor dose has not been evaluated due to the high dependence on its contouring. Small lesion size, hot spots in health tissue and blurred limits can affect a lot the dose distributionmore » in tumors. Extra work includes: export and import of images and other dicom files, create and calculate a dummy plan of external radiotherapy, convolution calculation and evaluation of the dose distribution with dicompyler. Total time spent is less than 2 hours. Conclusion: VSV calculations do not require any extra appointment or any uncomfortable process for patient. The total process is short enough to carry it out the same day of simulation and to contribute to prescription decisions prior to treatment. Three-dimensional dose knowledge provides much more information than other methods of dose calculation usually applied in the clinic.« less

Authors:
; ; ; ; ; ; ; ; ; ;  [1];  [2]
  1. Complejo Hospitalario de Navarra, Pamplona, Navarra (Spain)
  2. Hospital Clinica Benidorm, Benidorm, Alicante (Spain)
Publication Date:
OSTI Identifier:
22545137
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ALBUMINS; ALGORITHMS; ANIMAL TISSUES; COMPUTER CODES; COMPUTERIZED TOMOGRAPHY; DOSIMETRY; IMAGE PROCESSING; LIVER; MICROSPHERES; NEOPLASMS; RADIOEMBOLIZATION; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPATIAL DOSE DISTRIBUTIONS; TECHNETIUM 99; YTTRIUM 90

Citation Formats

Maneru, F, Gracia, M, Gallardo, N, Olasolo, J, Fuentemilla, N, Bragado, L, Martin-Albina, M, Lozares, S, Pellejero, S, Miquelez, S, Rubio, A, and Otal, A. SU-E-T-02: 90Y Microspheres Dosimetry Calculation with Voxel-S-Value Method: A Simple Use in the Clinic. United States: N. p., 2015. Web. doi:10.1118/1.4924363.
Maneru, F, Gracia, M, Gallardo, N, Olasolo, J, Fuentemilla, N, Bragado, L, Martin-Albina, M, Lozares, S, Pellejero, S, Miquelez, S, Rubio, A, & Otal, A. SU-E-T-02: 90Y Microspheres Dosimetry Calculation with Voxel-S-Value Method: A Simple Use in the Clinic. United States. doi:10.1118/1.4924363.
Maneru, F, Gracia, M, Gallardo, N, Olasolo, J, Fuentemilla, N, Bragado, L, Martin-Albina, M, Lozares, S, Pellejero, S, Miquelez, S, Rubio, A, and Otal, A. Mon . "SU-E-T-02: 90Y Microspheres Dosimetry Calculation with Voxel-S-Value Method: A Simple Use in the Clinic". United States. doi:10.1118/1.4924363.
@article{osti_22545137,
title = {SU-E-T-02: 90Y Microspheres Dosimetry Calculation with Voxel-S-Value Method: A Simple Use in the Clinic},
author = {Maneru, F and Gracia, M and Gallardo, N and Olasolo, J and Fuentemilla, N and Bragado, L and Martin-Albina, M and Lozares, S and Pellejero, S and Miquelez, S and Rubio, A and Otal, A},
abstractNote = {Purpose: To present a simple and feasible method of voxel-S-value (VSV) dosimetry calculation for daily clinical use in radioembolization (RE) with {sup 90}Y microspheres. Dose distributions are obtained and visualized over CT images. Methods: Spatial dose distributions and dose in liver and tumor are calculated for RE patients treated with Sirtex Medical miscrospheres at our center. Data obtained from the previous simulation of treatment were the basis for calculations: Tc-99m maggregated albumin SPECT-CT study in a gammacamera (Infinia, General Electric Healthcare.). Attenuation correction and ordered-subsets expectation maximization (OSEM) algorithm were applied.For VSV calculations, both SPECT and CT were exported from the gammacamera workstation and registered with the radiotherapy treatment planning system (Eclipse, Varian Medical systems). Convolution of activity matrix and local dose deposition kernel (S values) was implemented with an in-house developed software based on Python code. The kernel was downloaded from www.medphys.it. Final dose distribution was evaluated with the free software Dicompyler. Results: Liver mean dose is consistent with Partition method calculations (accepted as a good standard). Tumor dose has not been evaluated due to the high dependence on its contouring. Small lesion size, hot spots in health tissue and blurred limits can affect a lot the dose distribution in tumors. Extra work includes: export and import of images and other dicom files, create and calculate a dummy plan of external radiotherapy, convolution calculation and evaluation of the dose distribution with dicompyler. Total time spent is less than 2 hours. Conclusion: VSV calculations do not require any extra appointment or any uncomfortable process for patient. The total process is short enough to carry it out the same day of simulation and to contribute to prescription decisions prior to treatment. Three-dimensional dose knowledge provides much more information than other methods of dose calculation usually applied in the clinic.},
doi = {10.1118/1.4924363},
journal = {Medical Physics},
number = 6,
volume = 42,
place = {United States},
year = {Mon Jun 15 00:00:00 EDT 2015},
month = {Mon Jun 15 00:00:00 EDT 2015}
}