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Title: SU-E-T-675: Remote Dosimetry with a Novel PRESAGE Formulation

Abstract

Purpose: 3D-gel dosimetry provides high-resolution treatment validation; however, scanners aren’t widely available. In remote dosimetry, dosimeters are shipped out from a central base institution to a remote site for irradiation, then shipped back for scanning and analysis, affording a convenient service for treatment validation to institutions lacking the necessary equipment and resources. Previous works demonstrated the high-resolution performance and temporal stability of PRESAGE. Here the newest formulation is investigated for remote dosimetry use. Methods: A new formulation of PRESAGE was created with the aim of improved color stability post irradiation. Dose sensitivity was determined by irradiating cuvettes on a Varian Linac (6MV) from 0–15Gy and measuring change in optical density at 633nm. Sensitivity readings were tracked over time in a temperature control study to determine long-term stability. A large volume study was performed to evaluate the accuracy for remote dosimetry. A 1kg dosimeter was pre-scanned, irradiated on-site with an 8Gy 4field box treatment, post-scanned and shipped to Princess Margaret Hospital for remote reading on an identical scanner. Results: Dose sensitivities ranged from 0.0194–0.0295 ΔOD/(Gy*cm)—similar to previous formulations. Post-irradiated cuvettes stored at 10°C retained 100% initial sensitivity over 5 days and 98.6% over 10 weeks while cuvettes stored at room temperaturemore » fell to 95.8% after 5 days and 37.4% after 10 weeks. The immediate and 5-day scans of the 4field box dosimeter data was reconstructed, registered to the corresponding eclipse dose-distribution, and compared with analytical tools in CERR. Immediate and 5-day scans looked visually similar. Line profiles revealed close agreement aside from a slight elevation in dose at the edge in the 5-day readout. Conclusion: The remote dosimetry formulation exhibits excellent temporal stability in small volumes. While immediate and 5-day readout scans of large volume dosimeters show promising agreement, further development is required to reduce an apparent time dependent edge elevation.« less

Authors:
; ;  [1];  [2];  [3]
  1. Duke University Medical Physics Graduate Program, Durham, NC (United States)
  2. Rider University, Lawrenceville, NJ (United States)
  3. Dept. of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)
Publication Date:
OSTI Identifier:
22538182
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DOSEMETERS; DOSIMETRY; GY RANGE; IRRADIATION; LINEAR ACCELERATORS; RADIATION DOSE DISTRIBUTIONS; READOUT SYSTEMS; SENSITIVITY; STABILITY; TEMPERATURE CONTROL; TEMPERATURE RANGE 0273-0400 K; TIME DEPENDENCE

Citation Formats

Mein, S, Juang, T, Malcolm, J, Adamovics, J, and Oldham, M. SU-E-T-675: Remote Dosimetry with a Novel PRESAGE Formulation. United States: N. p., 2015. Web. doi:10.1118/1.4925038.
Mein, S, Juang, T, Malcolm, J, Adamovics, J, & Oldham, M. SU-E-T-675: Remote Dosimetry with a Novel PRESAGE Formulation. United States. doi:10.1118/1.4925038.
Mein, S, Juang, T, Malcolm, J, Adamovics, J, and Oldham, M. Mon . "SU-E-T-675: Remote Dosimetry with a Novel PRESAGE Formulation". United States. doi:10.1118/1.4925038.
@article{osti_22538182,
title = {SU-E-T-675: Remote Dosimetry with a Novel PRESAGE Formulation},
author = {Mein, S and Juang, T and Malcolm, J and Adamovics, J and Oldham, M},
abstractNote = {Purpose: 3D-gel dosimetry provides high-resolution treatment validation; however, scanners aren’t widely available. In remote dosimetry, dosimeters are shipped out from a central base institution to a remote site for irradiation, then shipped back for scanning and analysis, affording a convenient service for treatment validation to institutions lacking the necessary equipment and resources. Previous works demonstrated the high-resolution performance and temporal stability of PRESAGE. Here the newest formulation is investigated for remote dosimetry use. Methods: A new formulation of PRESAGE was created with the aim of improved color stability post irradiation. Dose sensitivity was determined by irradiating cuvettes on a Varian Linac (6MV) from 0–15Gy and measuring change in optical density at 633nm. Sensitivity readings were tracked over time in a temperature control study to determine long-term stability. A large volume study was performed to evaluate the accuracy for remote dosimetry. A 1kg dosimeter was pre-scanned, irradiated on-site with an 8Gy 4field box treatment, post-scanned and shipped to Princess Margaret Hospital for remote reading on an identical scanner. Results: Dose sensitivities ranged from 0.0194–0.0295 ΔOD/(Gy*cm)—similar to previous formulations. Post-irradiated cuvettes stored at 10°C retained 100% initial sensitivity over 5 days and 98.6% over 10 weeks while cuvettes stored at room temperature fell to 95.8% after 5 days and 37.4% after 10 weeks. The immediate and 5-day scans of the 4field box dosimeter data was reconstructed, registered to the corresponding eclipse dose-distribution, and compared with analytical tools in CERR. Immediate and 5-day scans looked visually similar. Line profiles revealed close agreement aside from a slight elevation in dose at the edge in the 5-day readout. Conclusion: The remote dosimetry formulation exhibits excellent temporal stability in small volumes. While immediate and 5-day readout scans of large volume dosimeters show promising agreement, further development is required to reduce an apparent time dependent edge elevation.},
doi = {10.1118/1.4925038},
journal = {Medical Physics},
number = 6,
volume = 42,
place = {United States},
year = {Mon Jun 15 00:00:00 EDT 2015},
month = {Mon Jun 15 00:00:00 EDT 2015}
}