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Title: SU-E-T-663: Radiation Properties of a Water-Equivalent Material Formulated Using the Stoichiometric Analysis Method in Heavy Charged Particle Therapy

Abstract

Purpose: A material has been designed to be employed as water-equivalent in particle therapy using a previously established stoichiometric analysis method (SAM). After manufacturing, experimental verification of the material’s water-equivalent path length (WEPL) and analysis of its total inelastic nuclear interaction cross sections for proton beams were performed. Methods: Using the SAM, we optimized the material composed of three base materials, i.e., polyurethane, calcium carbonate and microspheres. From the elemental composition of the compound, electron density, linear attenuation coefficients, particle stopping powers and inelastic nuclear cross sections for protons using data from ICRU 63 were calculated. The calculations were then compared to Hounsfield units (HUs) measured with 350 mAs at 80, 100, 120 and 140 kV and the WEPLs measured with three different ions: proton (106.8 MeV/u), helium (107.93 MeV/u) and carbon (200.3 MeV/u). Results: The material’s measured HUs (0.7±3.0 to 2.6±6.2 HU) as well as its calculated relative electron density (1.0001) are in close agreement with water as reference. The WEPLs measured on a 20.00 mm thick target were 20.16±0.12, 20.29±0.12 and 20.38±0.12 mmH2O for proton, helium and carbon ions, respectively. Within measurement uncertainties, these values verified the calculated WEPLs of 20.28 mmH2O (proton), 20.28 mmH2O (helium) and 20.26more » mmH2O (carbon). Moreover, the calculated proton inelastic cross sections of the material differed only by 0.89% (100 MeV/u) and 0.01% (200 MeV/u) when compared to water. Conclusion: The SAM is capable of optimizing material with defined properties, e.g., HU, electron density, WEPL and inelastic nuclear interaction cross section for particle therapy. Such material will have a wide range of applications amongst others absolute dosimetry. This work was supported by grant ZIM KF2137107AK4 from the German Federal Ministry for Economic Affairs and Energy.« less

Authors:
;  [1]; ;  [2];  [3];  [1];  [4];  [4]
  1. University Hospital Erlangen, Erlangen, DE (Germany)
  2. GSI - Helmholtz Centre for Heavy Ion Research, Darmstadt, DE (Germany)
  3. QRM GmbH, Moehrendorf, DE (United States)
  4. (Germany)
Publication Date:
OSTI Identifier:
22538171
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
07 ISOTOPES AND RADIATION SOURCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; CALCIUM CARBONATES; CARBON IONS; CROSS SECTIONS; ELECTRON DENSITY; HELIUM; MEV RANGE 100-1000; MEV RANGE 10-100; PROTON BEAMS; RADIOTHERAPY; STOICHIOMETRY

Citation Formats

Yohannes, I, Vasiliniuc, S, Hild, S, Graeff, C, Langner, O, Bert, C, GSI - Helmholtz Centre for Heavy Ion Research, Darmstadt, DE, and Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, DE. SU-E-T-663: Radiation Properties of a Water-Equivalent Material Formulated Using the Stoichiometric Analysis Method in Heavy Charged Particle Therapy. United States: N. p., 2015. Web. doi:10.1118/1.4925026.
Yohannes, I, Vasiliniuc, S, Hild, S, Graeff, C, Langner, O, Bert, C, GSI - Helmholtz Centre for Heavy Ion Research, Darmstadt, DE, & Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, DE. SU-E-T-663: Radiation Properties of a Water-Equivalent Material Formulated Using the Stoichiometric Analysis Method in Heavy Charged Particle Therapy. United States. doi:10.1118/1.4925026.
Yohannes, I, Vasiliniuc, S, Hild, S, Graeff, C, Langner, O, Bert, C, GSI - Helmholtz Centre for Heavy Ion Research, Darmstadt, DE, and Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, DE. Mon . "SU-E-T-663: Radiation Properties of a Water-Equivalent Material Formulated Using the Stoichiometric Analysis Method in Heavy Charged Particle Therapy". United States. doi:10.1118/1.4925026.
@article{osti_22538171,
title = {SU-E-T-663: Radiation Properties of a Water-Equivalent Material Formulated Using the Stoichiometric Analysis Method in Heavy Charged Particle Therapy},
author = {Yohannes, I and Vasiliniuc, S and Hild, S and Graeff, C and Langner, O and Bert, C and GSI - Helmholtz Centre for Heavy Ion Research, Darmstadt, DE and Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, DE},
abstractNote = {Purpose: A material has been designed to be employed as water-equivalent in particle therapy using a previously established stoichiometric analysis method (SAM). After manufacturing, experimental verification of the material’s water-equivalent path length (WEPL) and analysis of its total inelastic nuclear interaction cross sections for proton beams were performed. Methods: Using the SAM, we optimized the material composed of three base materials, i.e., polyurethane, calcium carbonate and microspheres. From the elemental composition of the compound, electron density, linear attenuation coefficients, particle stopping powers and inelastic nuclear cross sections for protons using data from ICRU 63 were calculated. The calculations were then compared to Hounsfield units (HUs) measured with 350 mAs at 80, 100, 120 and 140 kV and the WEPLs measured with three different ions: proton (106.8 MeV/u), helium (107.93 MeV/u) and carbon (200.3 MeV/u). Results: The material’s measured HUs (0.7±3.0 to 2.6±6.2 HU) as well as its calculated relative electron density (1.0001) are in close agreement with water as reference. The WEPLs measured on a 20.00 mm thick target were 20.16±0.12, 20.29±0.12 and 20.38±0.12 mmH2O for proton, helium and carbon ions, respectively. Within measurement uncertainties, these values verified the calculated WEPLs of 20.28 mmH2O (proton), 20.28 mmH2O (helium) and 20.26 mmH2O (carbon). Moreover, the calculated proton inelastic cross sections of the material differed only by 0.89% (100 MeV/u) and 0.01% (200 MeV/u) when compared to water. Conclusion: The SAM is capable of optimizing material with defined properties, e.g., HU, electron density, WEPL and inelastic nuclear interaction cross section for particle therapy. Such material will have a wide range of applications amongst others absolute dosimetry. This work was supported by grant ZIM KF2137107AK4 from the German Federal Ministry for Economic Affairs and Energy.},
doi = {10.1118/1.4925026},
journal = {Medical Physics},
number = 6,
volume = 42,
place = {United States},
year = {Mon Jun 15 00:00:00 EDT 2015},
month = {Mon Jun 15 00:00:00 EDT 2015}
}