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Title: Obtaining of biodegradable polylactide films and fibers filled hydroxyapatite for medical purposes

Abstract

Relevance of the work is due to the need for new materials that are used in medicine (orthopedics, surgery, dentistry, and others) as a substitute for natural bone tissue injuries, fractures, etc. The aim of presented work is developing of a method of producing biocompatible materials based on polyesters of hydroxycarboxylic acids and calcium phosphate ceramic (hydroxyapatite, HA) with homogeneous distribution of the inorganic component. Bioactive composites based on poly-L-lactide (PL) and hydroxyapatite with homogeneous distribution were prepared. The results of scanning electron microscopy confirm homogeneous distribution of the inorganic filler in the polymer matrix. The positive effect of ultrasound on the homogeneity of the composites was determined. The rate of hydrolysis of composites was evaluated. The rate of hydrolysis of polylactide as an individual substance is 7 times lower than the rate of hydrolysis of the polylactide as a part of the composite. It was found that materials submarines HA composite and do not cause a negative response in the cells of the immune system, while contributing to anti-inflammatory cytokines released by cells.

Authors:
; ; ; ;  [1]
  1. National Research Tomsk State University 36, Lenina Avenue, Tomsk, 634050 (Russian Federation)
Publication Date:
OSTI Identifier:
22496173
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1688; Journal Issue: 1; Conference: NEWOT'2015: 5. international scientific conference on new operational technologies, Tomsk (Russian Federation), 29-30 Sep 2015; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES; APATITES; BIODEGRADATION; BONE TISSUES; CALCIUM PHOSPHATES; CERAMICS; DENTISTRY; DISTRIBUTION; FIBERS; FILMS; FRACTURES; HYDROLYSIS; INFLAMMATION; INJURIES; LYMPHOKINES; POLYESTERS; SCANNING ELECTRON MICROSCOPY; SURGERY; ULTRASONIC WAVES

Citation Formats

Lytkina, D. N., E-mail: darya-lytkina@yandex.ru, Shapovalova, Y. G., E-mail: elena.shapovalova@ro.ru, Rasskazova, L. A., E-mail: ly-2207@mail.ru, Kurzina, I. A., E-mail: kurzina99@mail.ru, and Filimoshkin, A. G., E-mail: filag05@rambler.ru. Obtaining of biodegradable polylactide films and fibers filled hydroxyapatite for medical purposes. United States: N. p., 2015. Web. doi:10.1063/1.4936055.
Lytkina, D. N., E-mail: darya-lytkina@yandex.ru, Shapovalova, Y. G., E-mail: elena.shapovalova@ro.ru, Rasskazova, L. A., E-mail: ly-2207@mail.ru, Kurzina, I. A., E-mail: kurzina99@mail.ru, & Filimoshkin, A. G., E-mail: filag05@rambler.ru. Obtaining of biodegradable polylactide films and fibers filled hydroxyapatite for medical purposes. United States. https://doi.org/10.1063/1.4936055
Lytkina, D. N., E-mail: darya-lytkina@yandex.ru, Shapovalova, Y. G., E-mail: elena.shapovalova@ro.ru, Rasskazova, L. A., E-mail: ly-2207@mail.ru, Kurzina, I. A., E-mail: kurzina99@mail.ru, and Filimoshkin, A. G., E-mail: filag05@rambler.ru. 2015. "Obtaining of biodegradable polylactide films and fibers filled hydroxyapatite for medical purposes". United States. https://doi.org/10.1063/1.4936055.
@article{osti_22496173,
title = {Obtaining of biodegradable polylactide films and fibers filled hydroxyapatite for medical purposes},
author = {Lytkina, D. N., E-mail: darya-lytkina@yandex.ru and Shapovalova, Y. G., E-mail: elena.shapovalova@ro.ru and Rasskazova, L. A., E-mail: ly-2207@mail.ru and Kurzina, I. A., E-mail: kurzina99@mail.ru and Filimoshkin, A. G., E-mail: filag05@rambler.ru},
abstractNote = {Relevance of the work is due to the need for new materials that are used in medicine (orthopedics, surgery, dentistry, and others) as a substitute for natural bone tissue injuries, fractures, etc. The aim of presented work is developing of a method of producing biocompatible materials based on polyesters of hydroxycarboxylic acids and calcium phosphate ceramic (hydroxyapatite, HA) with homogeneous distribution of the inorganic component. Bioactive composites based on poly-L-lactide (PL) and hydroxyapatite with homogeneous distribution were prepared. The results of scanning electron microscopy confirm homogeneous distribution of the inorganic filler in the polymer matrix. The positive effect of ultrasound on the homogeneity of the composites was determined. The rate of hydrolysis of composites was evaluated. The rate of hydrolysis of polylactide as an individual substance is 7 times lower than the rate of hydrolysis of the polylactide as a part of the composite. It was found that materials submarines HA composite and do not cause a negative response in the cells of the immune system, while contributing to anti-inflammatory cytokines released by cells.},
doi = {10.1063/1.4936055},
url = {https://www.osti.gov/biblio/22496173}, journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1688,
place = {United States},
year = {2015},
month = {11}
}