Visualization and quantification of magnetic nanoparticles into vesicular systems by combined atomic and magnetic force microscopy
- Department of Basic and Applied Sciences for Engineering, SAPIENZA University of Rome, Via A. Scarpa 16, 00161, Rome (Italy)
- Department of Public Health and Infectious Diseases, SAPIENZA University of Rome, Piazzale A. Moro 5, 00185, Rome (Italy)
- Center for Life Nano Science @ Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome (Italy)
- Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità (ISS), Viale Regina Elena 299, 00161, Rome (Italy)
We report a phenomenological approach for the quantification of the diameter of magnetic nanoparticles (MNPs) incorporated in non-ionic surfactant vesicles (niosomes) using magnetic force microscopy (MFM). After a simple specimen preparation, i.e., by putting a drop of solution containing MNPs-loaded niosomes on flat substrates, topography and MFM phase images are collected. To attempt the quantification of the diameter of entrapped MNPs, the method is calibrated on the sole MNPs deposited on the same substrates by analyzing the MFM signal as a function of the MNP diameter (at fixed tip-sample distance) and of the tip-sample distance (for selected MNPs). After calibration, the effective diameter of the MNPs entrapped in some niosomes is quantitatively deduced from MFM images.
- OSTI ID:
- 22490683
- Journal Information:
- AIP Conference Proceedings, Vol. 1667, Issue 1; Conference: Nanoforum 2014, Rome (Italy), 22-25 Sep 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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