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Title: Peripheral white blood cells profile of biodegradable metal implant in mice animal model

Abstract

Biocompatibility or safety of the medical device is considered important. It can be determined by blood profile examination. The aim of this study was to assess the biocompatibility of biodegradable metal implant through peripheral white blood cells (WBCs) profile approach. Forty eight male ddy mice were divided into four groups according to the materials implanted: iron wire (Fe), magnesium rod (Mg), stainless steel surgical wire (SS316L) and control with sham (K). Implants were inserted and attached onto the right femoral bone on latero-medial region. In this study, peripheral white blood cells and leukocyte differentiation were the parameters examined. The result showed that the WBCs value of all groups were decreased at the first day after implantation, increased at the 10th day and continued increasing at the 30th day of observation, except Mg group which has decreased. Neutrophil, as an inflammatory cells, was increased at the early weeks and decreased at the day-30 after surgery in all groups. Despite, these values during the observation were still within the normal range. As a conclus ion, biodegradable metal implants lead to an inflammatory reaction, with no adverse effect on WBC value found.

Authors:
; ;  [1];  [1];  [2];  [3];  [4];  [5]
  1. Faculty of Veterinary Medicine, Bogor Agricultural University (IPB), Bogor (Indonesia)
  2. (UTM), Johor Bahru (Malaysia)
  3. Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), Johor Bahru (Malaysia)
  4. (UMRI), Pekanbaru (Indonesia)
  5. Department of Mining, Metallurgical and Materials Engineering & CHU de Québec Research Center, Laval University (ULaval) (Canada)
Publication Date:
OSTI Identifier:
22488938
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1677; Journal Issue: 1; Conference: 5. international conference on mathematics and natural sciences, Bandung (Indonesia), 2-3 Nov 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BIODEGRADATION; IMPLANTS; INFLAMMATION; IRON; LEUKOCYTES; MAGNESIUM; MALES; MICE; NEUTROPHILS; SKELETON; STAINLESS STEELS; SURGERY

Citation Formats

Paramitha, Devi, Noviana, Deni, E-mail: deni@ipb.ac.id, Estuningsih, Sri, Ulum, Mokhamad Fakhrul, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Nasution, Ahmad Kafrawi, Faculty of Engineering, Muhammadiyah University of Riau, and Hermawan, Hendra. Peripheral white blood cells profile of biodegradable metal implant in mice animal model. United States: N. p., 2015. Web. doi:10.1063/1.4930726.
Paramitha, Devi, Noviana, Deni, E-mail: deni@ipb.ac.id, Estuningsih, Sri, Ulum, Mokhamad Fakhrul, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Nasution, Ahmad Kafrawi, Faculty of Engineering, Muhammadiyah University of Riau, & Hermawan, Hendra. Peripheral white blood cells profile of biodegradable metal implant in mice animal model. United States. doi:10.1063/1.4930726.
Paramitha, Devi, Noviana, Deni, E-mail: deni@ipb.ac.id, Estuningsih, Sri, Ulum, Mokhamad Fakhrul, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Nasution, Ahmad Kafrawi, Faculty of Engineering, Muhammadiyah University of Riau, and Hermawan, Hendra. Wed . "Peripheral white blood cells profile of biodegradable metal implant in mice animal model". United States. doi:10.1063/1.4930726.
@article{osti_22488938,
title = {Peripheral white blood cells profile of biodegradable metal implant in mice animal model},
author = {Paramitha, Devi and Noviana, Deni, E-mail: deni@ipb.ac.id and Estuningsih, Sri and Ulum, Mokhamad Fakhrul and Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia and Nasution, Ahmad Kafrawi and Faculty of Engineering, Muhammadiyah University of Riau and Hermawan, Hendra},
abstractNote = {Biocompatibility or safety of the medical device is considered important. It can be determined by blood profile examination. The aim of this study was to assess the biocompatibility of biodegradable metal implant through peripheral white blood cells (WBCs) profile approach. Forty eight male ddy mice were divided into four groups according to the materials implanted: iron wire (Fe), magnesium rod (Mg), stainless steel surgical wire (SS316L) and control with sham (K). Implants were inserted and attached onto the right femoral bone on latero-medial region. In this study, peripheral white blood cells and leukocyte differentiation were the parameters examined. The result showed that the WBCs value of all groups were decreased at the first day after implantation, increased at the 10th day and continued increasing at the 30th day of observation, except Mg group which has decreased. Neutrophil, as an inflammatory cells, was increased at the early weeks and decreased at the day-30 after surgery in all groups. Despite, these values during the observation were still within the normal range. As a conclus ion, biodegradable metal implants lead to an inflammatory reaction, with no adverse effect on WBC value found.},
doi = {10.1063/1.4930726},
journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1677,
place = {United States},
year = {2015},
month = {9}
}