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Title: Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent

Abstract

Continuous bead-free C-type cubic gadolinium oxide (Gd{sub 2}O{sub 3}) nanofibers 20-30 μm long and 40-100 nm in diameter were sintered by sol-gel calcination assisted electrospinning technique. Dipole-dipole interaction of neighboring Gd{sup 3+} ions in nanofibers with large length-to-diameter aspect ratio results in some kind of superparamagnetic behavior: fibers are magnetized twice stronger than Gd{sub 2}O{sub 3} powder. Being compared with commercial Gd-DTPA/Magnevist{sup ®}, Gd{sub 2}O{sub 3} diethyleneglycol-coated (Gd{sub 2}O{sub 3}-DEG) fibers show high 1/T{sub 1} and 1/T{sub 2} proton relaxivities. Intense room temperature photoluminescence, high NMR relaxivity and high neutron scattering cross-section of {sup 157}Gd nucleus promise to integrate Gd{sub 2}O{sub 3} fibers for multimodal bioimaging and neutron capture therapy.

Authors:
 [1];  [2];  [3];  [1];  [2];  [4]
  1. KTH Royal Institute of Technology, SE-164 40 Stockholm-Kista (Sweden)
  2. (Sweden)
  3. (Russian Federation)
  4. Racah Institute of Physics, Hebrew University of Jerusalem, 91904 Jerusalem (Israel)
Publication Date:
OSTI Identifier:
22488566
Resource Type:
Journal Article
Journal Name:
AIP Advances
Additional Journal Information:
Journal Volume: 5; Journal Issue: 5; Other Information: (c) 2015 Author(s); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 2158-3226
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY; ASPECT RATIO; CALCINATION; COMPARATIVE EVALUATIONS; CROSS SECTIONS; DIPOLES; FIBERS; GADOLINIUM 157; GADOLINIUM IONS; GADOLINIUM OXIDES; INTERACTIONS; NANOFIBERS; NEUTRON CAPTURE THERAPY; NEUTRON DIFFRACTION; NUCLEAR MAGNETIC RESONANCE; PHOTOLUMINESCENCE; POWDERS; PROTONS; SOL-GEL PROCESS; SUPERPARAMAGNETISM

Citation Formats

Grishin, A. M., E-mail: grishin@kth.se, E-mail: grishin@inmatech.com, INMATECH Intelligent Materials Technology, SE-127 45 Skärholmen, Petrozavodsk State University, 185910 Petrozavodsk, Karelian Republic, Jalalian, A., INMATECH Intelligent Materials Technology, SE-127 45 Skärholmen, and Tsindlekht, M. I. Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent. United States: N. p., 2015. Web. doi:10.1063/1.4919810.
Grishin, A. M., E-mail: grishin@kth.se, E-mail: grishin@inmatech.com, INMATECH Intelligent Materials Technology, SE-127 45 Skärholmen, Petrozavodsk State University, 185910 Petrozavodsk, Karelian Republic, Jalalian, A., INMATECH Intelligent Materials Technology, SE-127 45 Skärholmen, & Tsindlekht, M. I. Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent. United States. doi:10.1063/1.4919810.
Grishin, A. M., E-mail: grishin@kth.se, E-mail: grishin@inmatech.com, INMATECH Intelligent Materials Technology, SE-127 45 Skärholmen, Petrozavodsk State University, 185910 Petrozavodsk, Karelian Republic, Jalalian, A., INMATECH Intelligent Materials Technology, SE-127 45 Skärholmen, and Tsindlekht, M. I. Fri . "Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent". United States. doi:10.1063/1.4919810.
@article{osti_22488566,
title = {Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent},
author = {Grishin, A. M., E-mail: grishin@kth.se, E-mail: grishin@inmatech.com and INMATECH Intelligent Materials Technology, SE-127 45 Skärholmen and Petrozavodsk State University, 185910 Petrozavodsk, Karelian Republic and Jalalian, A. and INMATECH Intelligent Materials Technology, SE-127 45 Skärholmen and Tsindlekht, M. I.},
abstractNote = {Continuous bead-free C-type cubic gadolinium oxide (Gd{sub 2}O{sub 3}) nanofibers 20-30 μm long and 40-100 nm in diameter were sintered by sol-gel calcination assisted electrospinning technique. Dipole-dipole interaction of neighboring Gd{sup 3+} ions in nanofibers with large length-to-diameter aspect ratio results in some kind of superparamagnetic behavior: fibers are magnetized twice stronger than Gd{sub 2}O{sub 3} powder. Being compared with commercial Gd-DTPA/Magnevist{sup ®}, Gd{sub 2}O{sub 3} diethyleneglycol-coated (Gd{sub 2}O{sub 3}-DEG) fibers show high 1/T{sub 1} and 1/T{sub 2} proton relaxivities. Intense room temperature photoluminescence, high NMR relaxivity and high neutron scattering cross-section of {sup 157}Gd nucleus promise to integrate Gd{sub 2}O{sub 3} fibers for multimodal bioimaging and neutron capture therapy.},
doi = {10.1063/1.4919810},
journal = {AIP Advances},
issn = {2158-3226},
number = 5,
volume = 5,
place = {United States},
year = {2015},
month = {5}
}