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Title: SU-E-U-02: The Development of a Practical Ultrasonic System for Cross-Sectional Imaging of Small Animals

Abstract

Purpose: To test the feasibility of developing a practical medium frequency ultrasound tomography method for small animal imaging. The ability to produce cross-sectional or full body images of a live small animal using a low-cost tabletop ultrasound scanner without any special license would be very beneficial to long term biological studies, where repeated scanning is often required over an extended period of time. Methods: The cross sectional images were produced by compounding multiple B-scans of a laboratory phantom or an animal acquired at different projection angles. Two imaging systems were used to test the concept. The first system included a programmable 64-channel phased array controller driving a 128-channel, 5–10 MHz linear probe to produce 143 B-Mode projections of the spinning object. The second system designed and manufactured in house, produced 64 or 128 B-Mode projections with a single unfocused 8 MHz transducer scanning with a 0.116 mm step size. Results: The phased array system provided good penetration through the phantoms/mice (with the exception of the lungs) and allowed to acquire data in a very short time. The cross-sectional images have enough resolution and dynamic range to detect both high- and low-contrast organs. The single transducer system takes longer to scan,more » and the data require more sophisticated processing. To date, our images allow seeing details as small as 1–2 mm in the phantoms and in small animals, with the contrast mostly due to highly reflecting bones and air inclusions. Conclusion: The work indicates that very detailed and anatomically correct images can be created by relatively simple and inexpensive means. With more advanced algorithms and improved system design, scan time can be reduced considerably, enabling high-resolution full 3D imaging. This will allow for quick and easy scans that can help monitor tumor growth and/or regression without contributing any dose to the animal. The authors would like to acknowledge the financial and engineering support from Tessonics.« less

Authors:
 [1];  [2];  [3];  [4];  [3];  [5];  [6];  [1];  [2];  [4];  [6];  [6]
  1. Wayne State University, Detroit, MI (United States)
  2. (United States)
  3. Karmanos Cancer Institute - International Imaging Center, Detroit, MI (United States)
  4. (United Kingdom)
  5. True Phantoms Solutions, Windsor, ON (Canada)
  6. (Canada)
Publication Date:
OSTI Identifier:
22486707
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ALGORITHMS; BIOMEDICAL RADIOGRAPHY; DESIGN; IMAGES; LUNGS; MICE; NEOPLASMS; PHANTOMS; RADIATION DOSES; SKELETON; TOMOGRAPHY

Citation Formats

Kamp, J, Karmanos Cancer Institute - International Imaging Center, Detroit, MI, Malyarenko, E, Tessonics Corp, Birmingham, MI, Chen, D, Wydra, A, University of Windsor - Institute for Diagnostic Imaging Research, Windsor, ON, Maev, R, Karmanos Cancer Institute - International Imaging Center, Detroit, MI, Tessonics Corp, Birmingham, MI, True Phantoms Solutions, Windsor, ON, and University of Windsor - Institute for Diagnostic Imaging Research, Windsor, ON. SU-E-U-02: The Development of a Practical Ultrasonic System for Cross-Sectional Imaging of Small Animals. United States: N. p., 2015. Web. doi:10.1118/1.4923995.
Kamp, J, Karmanos Cancer Institute - International Imaging Center, Detroit, MI, Malyarenko, E, Tessonics Corp, Birmingham, MI, Chen, D, Wydra, A, University of Windsor - Institute for Diagnostic Imaging Research, Windsor, ON, Maev, R, Karmanos Cancer Institute - International Imaging Center, Detroit, MI, Tessonics Corp, Birmingham, MI, True Phantoms Solutions, Windsor, ON, & University of Windsor - Institute for Diagnostic Imaging Research, Windsor, ON. SU-E-U-02: The Development of a Practical Ultrasonic System for Cross-Sectional Imaging of Small Animals. United States. doi:10.1118/1.4923995.
Kamp, J, Karmanos Cancer Institute - International Imaging Center, Detroit, MI, Malyarenko, E, Tessonics Corp, Birmingham, MI, Chen, D, Wydra, A, University of Windsor - Institute for Diagnostic Imaging Research, Windsor, ON, Maev, R, Karmanos Cancer Institute - International Imaging Center, Detroit, MI, Tessonics Corp, Birmingham, MI, True Phantoms Solutions, Windsor, ON, and University of Windsor - Institute for Diagnostic Imaging Research, Windsor, ON. Mon . "SU-E-U-02: The Development of a Practical Ultrasonic System for Cross-Sectional Imaging of Small Animals". United States. doi:10.1118/1.4923995.
@article{osti_22486707,
title = {SU-E-U-02: The Development of a Practical Ultrasonic System for Cross-Sectional Imaging of Small Animals},
author = {Kamp, J and Karmanos Cancer Institute - International Imaging Center, Detroit, MI and Malyarenko, E and Tessonics Corp, Birmingham, MI and Chen, D and Wydra, A and University of Windsor - Institute for Diagnostic Imaging Research, Windsor, ON and Maev, R and Karmanos Cancer Institute - International Imaging Center, Detroit, MI and Tessonics Corp, Birmingham, MI and True Phantoms Solutions, Windsor, ON and University of Windsor - Institute for Diagnostic Imaging Research, Windsor, ON},
abstractNote = {Purpose: To test the feasibility of developing a practical medium frequency ultrasound tomography method for small animal imaging. The ability to produce cross-sectional or full body images of a live small animal using a low-cost tabletop ultrasound scanner without any special license would be very beneficial to long term biological studies, where repeated scanning is often required over an extended period of time. Methods: The cross sectional images were produced by compounding multiple B-scans of a laboratory phantom or an animal acquired at different projection angles. Two imaging systems were used to test the concept. The first system included a programmable 64-channel phased array controller driving a 128-channel, 5–10 MHz linear probe to produce 143 B-Mode projections of the spinning object. The second system designed and manufactured in house, produced 64 or 128 B-Mode projections with a single unfocused 8 MHz transducer scanning with a 0.116 mm step size. Results: The phased array system provided good penetration through the phantoms/mice (with the exception of the lungs) and allowed to acquire data in a very short time. The cross-sectional images have enough resolution and dynamic range to detect both high- and low-contrast organs. The single transducer system takes longer to scan, and the data require more sophisticated processing. To date, our images allow seeing details as small as 1–2 mm in the phantoms and in small animals, with the contrast mostly due to highly reflecting bones and air inclusions. Conclusion: The work indicates that very detailed and anatomically correct images can be created by relatively simple and inexpensive means. With more advanced algorithms and improved system design, scan time can be reduced considerably, enabling high-resolution full 3D imaging. This will allow for quick and easy scans that can help monitor tumor growth and/or regression without contributing any dose to the animal. The authors would like to acknowledge the financial and engineering support from Tessonics.},
doi = {10.1118/1.4923995},
journal = {Medical Physics},
number = 6,
volume = 42,
place = {United States},
year = {Mon Jun 15 00:00:00 EDT 2015},
month = {Mon Jun 15 00:00:00 EDT 2015}
}