SU-E-P-18: Intensity-Modulated Radiation Therapy for Cervical Esophageal Squamous Cell Carcinoma

Bai, W; Qiao, X; Zhou, Z; Song, Y; Zhang, R; Zhen, C

doi:10.1118/1.4923952

Title: SU-E-P-18: Intensity-Modulated Radiation Therapy for Cervical Esophageal Squamous Cell Carcinoma

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Abstract

Purpose: To retrospectively analyze the outcomes and prognostic factors of cervical esophageal squamous cell carcinoma (SCC) treated with intensity modulated radiation therapy (IMRT). Methods: Thirty-seven patients with cervical esophageal SCC treated with IMRT were analyzed retrospectively. They received 54–66 Gy in 27–32 fractions. Nineteen patients received concurrent (n=12) or sequential (n=7) platinum-based two drugs chemoradiotherapy. Overall survival (OS), local control rates (LCR) and prognostic factors were evaluated. Acute toxicities and patterns of first failures were observed. Results: The median follow-up was 46 months for alive patients. The l-, 3-, 4- and 5-year OS of the all patients were 83.8%, 59.1%, 47.5% and 32.6% respectively. The median survival time was 46 months. The l-, 3-,4- and 5-year LCR were 82.9%, 63.0%, 54.5% and 54.5%, respectively. Univariate and Multivariate analysis all showed that size of GTV was an independent prognostic factor (p=0.033, p=0.039). There were no patients with Grade 3 acute radiation esophagitis and Grade 2–4 acute pneumonitis. The local failure accounted for 70.0% of all treatment-related failures. Conclusion: IMRT is safe and effective in the treatment of cervical esophageal squamous cell carcinoma. Size of GTV is an independent prognostic factor. Local failure still remains the main reason of treatment failures. Themore »« less

Authors:

Bai, W; Qiao, X; Zhou, Z; Song, Y; Zhang, R; Zhen, C ^[1]

The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei (China)

Publication Date:: Mon Jun 15 00:00:00 EDT 2015

OSTI Identifier:: 22486670

Resource Type:: Journal Article

Journal Name:: Medical Physics

Additional Journal Information:: Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; CARCINOMAS; COMBINED THERAPY; DRUGS; ESOPHAGUS; FAILURES; LOAD COLLECTOR RATIO; MULTIVARIATE ANALYSIS; PATIENTS; PNEUMONITIS; RADIOTHERAPY; SURVIVAL TIME; TOXICITY

Citation Formats


                    Bai, W, Qiao, X, Zhou, Z, Song, Y, Zhang, R, and Zhen, C. SU-E-P-18: Intensity-Modulated Radiation Therapy for Cervical Esophageal Squamous Cell Carcinoma.  United States: N. p., 2015. 
        Web.  doi:10.1118/1.4923952.

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                    Bai, W, Qiao, X, Zhou, Z, Song, Y, Zhang, R, & Zhen, C. SU-E-P-18: Intensity-Modulated Radiation Therapy for Cervical Esophageal Squamous Cell Carcinoma.  United States.  https://doi.org/10.1118/1.4923952

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                    Bai, W, Qiao, X, Zhou, Z, Song, Y, Zhang, R, and Zhen, C. 2015.  
        "SU-E-P-18: Intensity-Modulated Radiation Therapy for Cervical Esophageal Squamous Cell Carcinoma".  United States.  https://doi.org/10.1118/1.4923952.

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@article{osti_22486670,

  title        = {SU-E-P-18: Intensity-Modulated Radiation Therapy for Cervical Esophageal Squamous Cell Carcinoma},

  author       = {Bai, W and Qiao, X and Zhou, Z and Song, Y and Zhang, R and Zhen, C},

  abstractNote = {Purpose: To retrospectively analyze the outcomes and prognostic factors of cervical esophageal squamous cell carcinoma (SCC) treated with intensity modulated radiation therapy (IMRT). Methods: Thirty-seven patients with cervical esophageal SCC treated with IMRT were analyzed retrospectively. They received 54–66 Gy in 27–32 fractions. Nineteen patients received concurrent (n=12) or sequential (n=7) platinum-based two drugs chemoradiotherapy. Overall survival (OS), local control rates (LCR) and prognostic factors were evaluated. Acute toxicities and patterns of first failures were observed. Results: The median follow-up was 46 months for alive patients. The l-, 3-, 4- and 5-year OS of the all patients were 83.8%, 59.1%, 47.5% and 32.6% respectively. The median survival time was 46 months. The l-, 3-,4- and 5-year LCR were 82.9%, 63.0%, 54.5% and 54.5%, respectively. Univariate and Multivariate analysis all showed that size of GTV was an independent prognostic factor (p=0.033, p=0.039). There were no patients with Grade 3 acute radiation esophagitis and Grade 2–4 acute pneumonitis. The local failure accounted for 70.0% of all treatment-related failures. Conclusion: IMRT is safe and effective in the treatment of cervical esophageal squamous cell carcinoma. Size of GTV is an independent prognostic factor. Local failure still remains the main reason of treatment failures. The authors declare no conflicts of interest in preparing this article.},

  doi          = {10.1118/1.4923952},

  url          = {https://www.osti.gov/biblio/22486670},
  journal      = {Medical Physics},

  issn         = {0094-2405},

  number       = 6,

  volume       = 42,

  place        = {United States},

  year         = {Mon Jun 15 00:00:00 EDT 2015},

  month        = {Mon Jun 15 00:00:00 EDT 2015}

}

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