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Title: Porous silicon nanoparticles as biocompatible contrast agents for magnetic resonance imaging

Abstract

We propose porous silicon nanoparticles (PSi NPs) with natural oxide coating as biocompatible and bioresorbable contrast agents for magnetic resonant imaging (MRI). A strong shortening of the transversal proton relaxation time (T{sub 2}) was observed for aqueous suspensions of PSi NPs, whereas the longitudinal relaxation time (T{sub 1}) changed moderately. The longitudinal and transversal relaxivities are estimated to be 0.03 and 0.4 l/(g·s), respectively, which are promising for biomedical studies. The proton relaxation is suggested to undergo via the magnetic dipole-dipole interaction with Si dangling bonds on surfaces of PSi NPs. MRI experiments with phantoms have revealed the remarkable contrasting properties of PSi NPs for medical diagnostics.

Authors:
; ;  [1];  [2]; ;  [3];  [4];  [1];  [1];  [2];  [1];  [2]
  1. Department of Physics, Lomonosov Moscow State University, 119991 Moscow (Russian Federation)
  2. (Russian Federation)
  3. Moscow Institute of Physics and Technology, Dolgoprudny, 141700 Moscow Region (Russian Federation)
  4. Research Center for MRI and MRS, Lomonosov Moscow State University, 119991 Moscow (Russian Federation)
Publication Date:
OSTI Identifier:
22486214
Resource Type:
Journal Article
Journal Name:
Applied Physics Letters
Additional Journal Information:
Journal Volume: 107; Journal Issue: 23; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0003-6951
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CONTRAST MEDIA; MAGNETIC DIPOLES; NANOPARTICLES; NMR IMAGING; PHANTOMS; POROUS MATERIALS; PROTONS; RELAXATION TIME; SILICON; SUSPENSIONS

Citation Formats

Gongalsky, M. B., E-mail: mgongalsky@gmail.com, Kargina, Yu. V., Osminkina, L. A., National Research Nuclear University “MEPhI,” 115409 Moscow, Perepukhov, A. M., Maximychev, A. V., Gulyaev, M. V., Vasiliev, A. N., Pirogov, Yu. A., Research Center for MRI and MRS, Lomonosov Moscow State University, 119991 Moscow, Timoshenko, V. Yu., and National Research Tomsk State University, 634050 Tomsk. Porous silicon nanoparticles as biocompatible contrast agents for magnetic resonance imaging. United States: N. p., 2015. Web. doi:10.1063/1.4937731.
Gongalsky, M. B., E-mail: mgongalsky@gmail.com, Kargina, Yu. V., Osminkina, L. A., National Research Nuclear University “MEPhI,” 115409 Moscow, Perepukhov, A. M., Maximychev, A. V., Gulyaev, M. V., Vasiliev, A. N., Pirogov, Yu. A., Research Center for MRI and MRS, Lomonosov Moscow State University, 119991 Moscow, Timoshenko, V. Yu., & National Research Tomsk State University, 634050 Tomsk. Porous silicon nanoparticles as biocompatible contrast agents for magnetic resonance imaging. United States. doi:10.1063/1.4937731.
Gongalsky, M. B., E-mail: mgongalsky@gmail.com, Kargina, Yu. V., Osminkina, L. A., National Research Nuclear University “MEPhI,” 115409 Moscow, Perepukhov, A. M., Maximychev, A. V., Gulyaev, M. V., Vasiliev, A. N., Pirogov, Yu. A., Research Center for MRI and MRS, Lomonosov Moscow State University, 119991 Moscow, Timoshenko, V. Yu., and National Research Tomsk State University, 634050 Tomsk. Mon . "Porous silicon nanoparticles as biocompatible contrast agents for magnetic resonance imaging". United States. doi:10.1063/1.4937731.
@article{osti_22486214,
title = {Porous silicon nanoparticles as biocompatible contrast agents for magnetic resonance imaging},
author = {Gongalsky, M. B., E-mail: mgongalsky@gmail.com and Kargina, Yu. V. and Osminkina, L. A. and National Research Nuclear University “MEPhI,” 115409 Moscow and Perepukhov, A. M. and Maximychev, A. V. and Gulyaev, M. V. and Vasiliev, A. N. and Pirogov, Yu. A. and Research Center for MRI and MRS, Lomonosov Moscow State University, 119991 Moscow and Timoshenko, V. Yu. and National Research Tomsk State University, 634050 Tomsk},
abstractNote = {We propose porous silicon nanoparticles (PSi NPs) with natural oxide coating as biocompatible and bioresorbable contrast agents for magnetic resonant imaging (MRI). A strong shortening of the transversal proton relaxation time (T{sub 2}) was observed for aqueous suspensions of PSi NPs, whereas the longitudinal relaxation time (T{sub 1}) changed moderately. The longitudinal and transversal relaxivities are estimated to be 0.03 and 0.4 l/(g·s), respectively, which are promising for biomedical studies. The proton relaxation is suggested to undergo via the magnetic dipole-dipole interaction with Si dangling bonds on surfaces of PSi NPs. MRI experiments with phantoms have revealed the remarkable contrasting properties of PSi NPs for medical diagnostics.},
doi = {10.1063/1.4937731},
journal = {Applied Physics Letters},
issn = {0003-6951},
number = 23,
volume = 107,
place = {United States},
year = {2015},
month = {12}
}