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Title: Electron string ion sources for carbon ion cancer therapy accelerators

Abstract

The type of the Electron String Ion Sources (ESIS) is considered to be the appropriate one to produce pulsed C{sup 4+} and C{sup 6+} ion beams for cancer therapy accelerators. In fact, the new test ESIS Krion-6T already now provides more than 10{sup 10} C{sup 4+} ions per pulse and about 5 × 10{sup 9} C{sup 6+} ions per pulse. Such ion sources could be suitable to apply at synchrotrons. It has also been found that Krion-6T can provide more than 10{sup 11} C{sup 6+} ions per second at the 100 Hz repetition rate, and the repetition rate can be increased at the same or larger ion output per second. This makes ESIS applicable at cyclotrons as well. ESIS can be also a suitable type of ion source to produce the {sup 11}C radioactive ion beams. A specialized cryogenic cell was experimentally tested at the Krion-2M ESIS for pulse injection of gaseous species into the electron string. It has been shown in experiments with stable methane that the total conversion efficiency of methane molecules to C{sup 4+} ions reached 5%÷10%. For cancer therapy with simultaneous irradiation and precise dose control (positron emission tomography) by means of {sup 11}C, transporting tomore » the tumor with the primary accelerated {sup 11}C{sup 4+} beam, this efficiency is preliminarily considered to be large enough to produce the {sup 11}C{sup 4+} beam from radioactive methane and to inject this beam into synchrotrons.« less

Authors:
; ; ; ; ; ; ;  [1]; ;  [2]
  1. Joint Institute for Nuclear Research, Dubna 141980 (Russian Federation)
  2. National Institute of Radiological Science, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)
Publication Date:
OSTI Identifier:
22482734
Resource Type:
Journal Article
Journal Name:
Review of Scientific Instruments
Additional Journal Information:
Journal Volume: 86; Journal Issue: 8; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0034-6748
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON 11 BEAMS; CARBON 9; CARBON IONS; CYCLOTRONS; ELECTRONS; ION SOURCES; METHANE; NEOPLASMS; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; SYNCHROTRONS; THERAPY

Citation Formats

Boytsov, A. Yu., Donets, D. E., Donets, E. D., Donets, E. E., Ponkin, D. O., Ramzdorf, A. Yu., Salnikov, V. V., Shutov, V. B., Katagiri, K., and Noda, K. Electron string ion sources for carbon ion cancer therapy accelerators. United States: N. p., 2015. Web. doi:10.1063/1.4927821.
Boytsov, A. Yu., Donets, D. E., Donets, E. D., Donets, E. E., Ponkin, D. O., Ramzdorf, A. Yu., Salnikov, V. V., Shutov, V. B., Katagiri, K., & Noda, K. Electron string ion sources for carbon ion cancer therapy accelerators. United States. https://doi.org/10.1063/1.4927821
Boytsov, A. Yu., Donets, D. E., Donets, E. D., Donets, E. E., Ponkin, D. O., Ramzdorf, A. Yu., Salnikov, V. V., Shutov, V. B., Katagiri, K., and Noda, K. 2015. "Electron string ion sources for carbon ion cancer therapy accelerators". United States. https://doi.org/10.1063/1.4927821.
@article{osti_22482734,
title = {Electron string ion sources for carbon ion cancer therapy accelerators},
author = {Boytsov, A. Yu. and Donets, D. E. and Donets, E. D. and Donets, E. E. and Ponkin, D. O. and Ramzdorf, A. Yu. and Salnikov, V. V. and Shutov, V. B. and Katagiri, K. and Noda, K.},
abstractNote = {The type of the Electron String Ion Sources (ESIS) is considered to be the appropriate one to produce pulsed C{sup 4+} and C{sup 6+} ion beams for cancer therapy accelerators. In fact, the new test ESIS Krion-6T already now provides more than 10{sup 10} C{sup 4+} ions per pulse and about 5 × 10{sup 9} C{sup 6+} ions per pulse. Such ion sources could be suitable to apply at synchrotrons. It has also been found that Krion-6T can provide more than 10{sup 11} C{sup 6+} ions per second at the 100 Hz repetition rate, and the repetition rate can be increased at the same or larger ion output per second. This makes ESIS applicable at cyclotrons as well. ESIS can be also a suitable type of ion source to produce the {sup 11}C radioactive ion beams. A specialized cryogenic cell was experimentally tested at the Krion-2M ESIS for pulse injection of gaseous species into the electron string. It has been shown in experiments with stable methane that the total conversion efficiency of methane molecules to C{sup 4+} ions reached 5%÷10%. For cancer therapy with simultaneous irradiation and precise dose control (positron emission tomography) by means of {sup 11}C, transporting to the tumor with the primary accelerated {sup 11}C{sup 4+} beam, this efficiency is preliminarily considered to be large enough to produce the {sup 11}C{sup 4+} beam from radioactive methane and to inject this beam into synchrotrons.},
doi = {10.1063/1.4927821},
url = {https://www.osti.gov/biblio/22482734}, journal = {Review of Scientific Instruments},
issn = {0034-6748},
number = 8,
volume = 86,
place = {United States},
year = {Sat Aug 15 00:00:00 EDT 2015},
month = {Sat Aug 15 00:00:00 EDT 2015}
}