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Title: Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron

Abstract

Purpose: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. Methods: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. Results: The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. Conclusions: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurementsmore » of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring.« less

Authors:
; ;  [1]; ; ;  [2]; ;  [3];  [4]
  1. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)
  2. Ion Beam Applications SA, Louvain-la-Neuve 1348 (Belgium)
  3. School of Biomedical Engineering, Drexel University, Philadelphia, Pennsylvania 19104 (United States)
  4. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)
Publication Date:
OSTI Identifier:
22482436
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 42; Journal Issue: 12; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ACOUSTIC MEASUREMENTS; AMPLITUDES; ENERGY ABSORPTION; ENERGY LOSSES; FUNCTION GENERATORS; HOSPITALS; IN VIVO; ISOCHRONOUS CYCLOTRONS; PATIENTS; PRESSURE RANGE MEGA PA; PROTON BEAMS; SOUND WAVES; VERIFICATION

Citation Formats

Jones, Kevin C., Solberg, Timothy D., Avery, Stephen, Vander Stappen, François, Janssens, Guillaume, Prieels, Damien, Bawiec, Christopher R., Lewin, Peter A., and Sehgal, Chandra M. Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron. United States: N. p., 2015. Web. doi:10.1118/1.4935865.
Jones, Kevin C., Solberg, Timothy D., Avery, Stephen, Vander Stappen, François, Janssens, Guillaume, Prieels, Damien, Bawiec, Christopher R., Lewin, Peter A., & Sehgal, Chandra M. Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron. United States. https://doi.org/10.1118/1.4935865
Jones, Kevin C., Solberg, Timothy D., Avery, Stephen, Vander Stappen, François, Janssens, Guillaume, Prieels, Damien, Bawiec, Christopher R., Lewin, Peter A., and Sehgal, Chandra M. 2015. "Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron". United States. https://doi.org/10.1118/1.4935865.
@article{osti_22482436,
title = {Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron},
author = {Jones, Kevin C. and Solberg, Timothy D. and Avery, Stephen and Vander Stappen, François and Janssens, Guillaume and Prieels, Damien and Bawiec, Christopher R. and Lewin, Peter A. and Sehgal, Chandra M.},
abstractNote = {Purpose: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. Methods: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. Results: The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. Conclusions: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring.},
doi = {10.1118/1.4935865},
url = {https://www.osti.gov/biblio/22482436}, journal = {Medical Physics},
issn = {0094-2405},
number = 12,
volume = 42,
place = {United States},
year = {Tue Dec 15 00:00:00 EST 2015},
month = {Tue Dec 15 00:00:00 EST 2015}
}