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Title: pH-responsive drug delivery system based on AIE luminogen functionalized layered zirconium phosphate nano-platelets

Abstract

Aggregation-induced emission (AIE) luminogen, quaternary tetraphenylethene cation (TPEN), was successfully incorporated into layered α-zirconium phosphate (α-ZrP) by using co-precipitation method to form inorganic–organic hybrid materials. The obtained materials show the characteristic hexagonal platelet shape with the interlayer distance did not reveal significant difference compared with pure α-ZrP. In addition, the obtained hybrid materials emit strong blue emission centered at 476 nm in aqueous media due to the electrostatic interactions of TPEN with the anionic framework of α-ZrP, which largely restrict their intramolecular rotation. More importantly, the materials provide a pH dependent release of doxorubicin (DOX), suggesting that AIE luminogen functionalized α-ZrP may be used as an imaging guided and pH-responsive delivery system for targeting therapy. - Graphical abstract: AIE luminogen was successfully incorporated into layered α-zirconium phosphate by a co-precipitation method to form inorganic–organic hybrid materials, showing a pH dependent release of DOX. - Highlights: • AIE luminogen cation was incorporated into layered α-ZrP by co-precipitation method. • The obtained material emits strong blue emission upon UV irradiation. • The material exhibits pH dependent release of DOX. • The AIE functionalized α-ZrP has potential applications in imaging guided therapy.

Authors:
; ;
Publication Date:
OSTI Identifier:
22475624
Resource Type:
Journal Article
Journal Name:
Journal of Solid State Chemistry
Additional Journal Information:
Journal Volume: 225; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0022-4596
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; AGGLOMERATION; CATIONS; COMPARATIVE EVALUATIONS; COPRECIPITATION; DOXORUBICIN; IRRADIATION; PH VALUE; ROTATION; STYRENE; ZIRCONIUM PHOSPHATES; ZIRCONIUM PHOSPHIDES

Citation Formats

Li, Dongdong, Zhang, Yuping, and Zhou, Bingbing. pH-responsive drug delivery system based on AIE luminogen functionalized layered zirconium phosphate nano-platelets. United States: N. p., 2015. Web. doi:10.1016/J.JSSC.2015.01.025.
Li, Dongdong, Zhang, Yuping, & Zhou, Bingbing. pH-responsive drug delivery system based on AIE luminogen functionalized layered zirconium phosphate nano-platelets. United States. doi:10.1016/J.JSSC.2015.01.025.
Li, Dongdong, Zhang, Yuping, and Zhou, Bingbing. Fri . "pH-responsive drug delivery system based on AIE luminogen functionalized layered zirconium phosphate nano-platelets". United States. doi:10.1016/J.JSSC.2015.01.025.
@article{osti_22475624,
title = {pH-responsive drug delivery system based on AIE luminogen functionalized layered zirconium phosphate nano-platelets},
author = {Li, Dongdong and Zhang, Yuping and Zhou, Bingbing},
abstractNote = {Aggregation-induced emission (AIE) luminogen, quaternary tetraphenylethene cation (TPEN), was successfully incorporated into layered α-zirconium phosphate (α-ZrP) by using co-precipitation method to form inorganic–organic hybrid materials. The obtained materials show the characteristic hexagonal platelet shape with the interlayer distance did not reveal significant difference compared with pure α-ZrP. In addition, the obtained hybrid materials emit strong blue emission centered at 476 nm in aqueous media due to the electrostatic interactions of TPEN with the anionic framework of α-ZrP, which largely restrict their intramolecular rotation. More importantly, the materials provide a pH dependent release of doxorubicin (DOX), suggesting that AIE luminogen functionalized α-ZrP may be used as an imaging guided and pH-responsive delivery system for targeting therapy. - Graphical abstract: AIE luminogen was successfully incorporated into layered α-zirconium phosphate by a co-precipitation method to form inorganic–organic hybrid materials, showing a pH dependent release of DOX. - Highlights: • AIE luminogen cation was incorporated into layered α-ZrP by co-precipitation method. • The obtained material emits strong blue emission upon UV irradiation. • The material exhibits pH dependent release of DOX. • The AIE functionalized α-ZrP has potential applications in imaging guided therapy.},
doi = {10.1016/J.JSSC.2015.01.025},
journal = {Journal of Solid State Chemistry},
issn = {0022-4596},
number = ,
volume = 225,
place = {United States},
year = {2015},
month = {5}
}