Local Control of Perivascular Malignant Liver Lesions Using Percutaneous Irreversible Electroporation: Initial Experiences

Journal Article · Sun Feb 15 00:00:00 EST 2015 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-014-0898-X· OSTI ID:22470102

Eller, Achim; Schmid, Axel ^[1]; Schmidt, Joachim ^[2]; May, Matthias; Brand, Michael; Saake, Marc; Uder, Michael; Lell, Michael ^[1]

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1. University Hospital Erlangen, University of Erlangen-Nuremberg, Department of Radiology (Germany)
2. University Hospital Erlangen, University of Erlangen-Nuremberg, Department of Anesthesiology (Germany)

PurposeThis study was designed to assess efficacy and safety in the treatment of perivascular malignant liver lesions using percutaneous, computed tomography (CT)-guided irreversible electroporation (IRE).MethodsFourteen patients (mean age 58 ± 11 years) with 18 malignant liver lesions were consecutively enrolled in this study. IRE was performed in patients not eligible for surgery and lesions abutting large vessels or bile ducts. Follow-up exams were performed using multislice-CT (MS-CT) or MRI.ResultsMedium lesion diameter was 20 ± 5 mm. Ten of 14 (71 %) were successfully treated with no local recurrence to date (mean follow-up 388 ± 160 days). One case left initial tumor control unclear and additional RFA was performed 4 weeks after IRE. Complications occurred in 4 of 14 (29 %) cases. In one case, intervention was terminated and abdominal bleeding required laparotomy. In two cases, a postinterventional hematothorax required intervention. In another case, abdominal bleeding could be managed conservatively. No complications related to the bile ducts occurred.ConclusionsPercutaneous IRE seems to be effective in perivascular lesions but is associated with a higher complication rate compared with thermoablative techniques.

• OSTI ID: 22470102
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 38, Issue 1; Conference: IROS 2015: Interventional Radiological Olbert Symposium, Berlin (Germany), 15-17 Jan 2015; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ADMINISTRATIVE PROCEDURES
BILIARY TRACT
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
CONTAINERS
DESIGN
LIVER
NEOPLASMS
NMR IMAGING
PATIENTS
SAFETY
SURGERY