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Title: Competing Risk Analysis of Neurologic versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage After Whole-Brain Radiation Therapy Failure: Who Actually Dies of Their Brain Metastases?

Abstract

Purpose: To estimate the hazard for neurologic (central nervous system, CNS) and nonneurologic (non-CNS) death associated with patient, treatment, and systemic disease status in patients receiving stereotactic radiosurgery after whole-brain radiation therapy (WBRT) failure, using a competing risk model. Patients and Methods: Of 757 patients, 293 experienced recurrence or new metastasis following WBRT. Univariate Cox proportional hazards regression identified covariates for consideration in the multivariate model. Competing risks multivariable regression was performed to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) for both CNS and non-CNS death after adjusting for patient, disease, and treatment factors. The resultant model was converted into an online calculator for ease of clinical use. Results: The cumulative incidence of CNS and non-CNS death at 6 and 12 months was 20.6% and 21.6%, and 34.4% and 35%, respectively. Patients with melanoma histology (relative to breast) (aHR 2.7, 95% CI 1.5-5.0), brainstem location (aHR 2.1, 95% CI 1.3-3.5), and number of metastases (aHR 1.09, 95% CI 1.04-1.2) had increased aHR for CNS death. Progressive systemic disease (aHR 0.55, 95% CI 0.4-0.8) and increasing lowest margin dose (aHR 0.97, 95% CI 0.9-0.99) were protective against CNS death. Patients with lung histology (aHR 1.3, 95% CI 1.1-1.9)more » and progressive systemic disease (aHR 2.14, 95% CI 1.5-3.0) had increased aHR for non-CNS death. Conclusion: Our nomogram provides individual estimates of neurologic death after salvage stereotactic radiosurgery for patients who have failed prior WBRT, based on histology, neuroanatomical location, age, lowest margin dose, and number of metastases after adjusting for their competing risk of death from other causes.« less

Authors:
;  [1]; ;  [2];  [3];  [4];  [5];  [6]
  1. Wake Forest School of Medicine, Winston-Salem, North Carolina (United States)
  2. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina (United States)
  3. Department of Radiation Oncology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina (United States)
  4. Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina (United States)
  5. Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, North Carolina (United States)
  6. Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina (United States)
Publication Date:
OSTI Identifier:
22462396
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 92; Journal Issue: 5; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; DEATH; HAZARDS; HISTOLOGY; LUNGS; MELANOMAS; METASTASES; NOMOGRAMS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; RISK ASSESSMENT; SURGERY

Citation Formats

Lucas, John T., E-mail: jolucas@wakehealth.edu, Colmer, Hentry G., White, Lance, Fitzgerald, Nora, Isom, Scott, Bourland, John D., Laxton, Adrian W., Tatter, Stephen B., and Chan, Michael D. Competing Risk Analysis of Neurologic versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage After Whole-Brain Radiation Therapy Failure: Who Actually Dies of Their Brain Metastases?. United States: N. p., 2015. Web. doi:10.1016/J.IJROBP.2015.04.032.
Lucas, John T., E-mail: jolucas@wakehealth.edu, Colmer, Hentry G., White, Lance, Fitzgerald, Nora, Isom, Scott, Bourland, John D., Laxton, Adrian W., Tatter, Stephen B., & Chan, Michael D. Competing Risk Analysis of Neurologic versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage After Whole-Brain Radiation Therapy Failure: Who Actually Dies of Their Brain Metastases?. United States. https://doi.org/10.1016/J.IJROBP.2015.04.032
Lucas, John T., E-mail: jolucas@wakehealth.edu, Colmer, Hentry G., White, Lance, Fitzgerald, Nora, Isom, Scott, Bourland, John D., Laxton, Adrian W., Tatter, Stephen B., and Chan, Michael D. 2015. "Competing Risk Analysis of Neurologic versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage After Whole-Brain Radiation Therapy Failure: Who Actually Dies of Their Brain Metastases?". United States. https://doi.org/10.1016/J.IJROBP.2015.04.032.
@article{osti_22462396,
title = {Competing Risk Analysis of Neurologic versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage After Whole-Brain Radiation Therapy Failure: Who Actually Dies of Their Brain Metastases?},
author = {Lucas, John T., E-mail: jolucas@wakehealth.edu and Colmer, Hentry G. and White, Lance and Fitzgerald, Nora and Isom, Scott and Bourland, John D. and Laxton, Adrian W. and Tatter, Stephen B. and Chan, Michael D.},
abstractNote = {Purpose: To estimate the hazard for neurologic (central nervous system, CNS) and nonneurologic (non-CNS) death associated with patient, treatment, and systemic disease status in patients receiving stereotactic radiosurgery after whole-brain radiation therapy (WBRT) failure, using a competing risk model. Patients and Methods: Of 757 patients, 293 experienced recurrence or new metastasis following WBRT. Univariate Cox proportional hazards regression identified covariates for consideration in the multivariate model. Competing risks multivariable regression was performed to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) for both CNS and non-CNS death after adjusting for patient, disease, and treatment factors. The resultant model was converted into an online calculator for ease of clinical use. Results: The cumulative incidence of CNS and non-CNS death at 6 and 12 months was 20.6% and 21.6%, and 34.4% and 35%, respectively. Patients with melanoma histology (relative to breast) (aHR 2.7, 95% CI 1.5-5.0), brainstem location (aHR 2.1, 95% CI 1.3-3.5), and number of metastases (aHR 1.09, 95% CI 1.04-1.2) had increased aHR for CNS death. Progressive systemic disease (aHR 0.55, 95% CI 0.4-0.8) and increasing lowest margin dose (aHR 0.97, 95% CI 0.9-0.99) were protective against CNS death. Patients with lung histology (aHR 1.3, 95% CI 1.1-1.9) and progressive systemic disease (aHR 2.14, 95% CI 1.5-3.0) had increased aHR for non-CNS death. Conclusion: Our nomogram provides individual estimates of neurologic death after salvage stereotactic radiosurgery for patients who have failed prior WBRT, based on histology, neuroanatomical location, age, lowest margin dose, and number of metastases after adjusting for their competing risk of death from other causes.},
doi = {10.1016/J.IJROBP.2015.04.032},
url = {https://www.osti.gov/biblio/22462396}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 92,
place = {United States},
year = {Sat Aug 01 00:00:00 EDT 2015},
month = {Sat Aug 01 00:00:00 EDT 2015}
}