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Title: Linear Energy Transfer Painting With Proton Therapy: A Means of Reducing Radiation Doses With Equivalent Clinical Effectiveness

Abstract

Purpose: The purpose of this study was to propose a proton treatment planning method that trades physical dose (D) for dose-averaged linear energy transfer (LET{sub d}) while keeping the radiobiologically weighted dose (D{sub RBE}) to the target the same. Methods and Materials: The target is painted with LET{sub d} by using 2, 4, and 7 fields aimed at the proximal segment of the target (split target planning [STP]). As the LET{sub d} within the target increases with increasing number of fields, D decreases to maintain the D{sub RBE} the same as the conventional treatment planning method by using beams treating the full target (full target planning [FTP]). Results: The LET{sub d} increased 61% for 2-field STP (2STP) compared to FTP, 72% for 4STP, and 82% for 7STP inside the target. This increase in LET{sub d} led to a decrease of D with 5.3 ± 0.6 Gy for 2STP, 4.4 ± 0.7 Gy for 4STP, and 5.3 ± 1.1 Gy for 7STP, keeping the DRBE at 90% of the volume (DRBE, 90) constant to FTP. Conclusions: LET{sub d} painting offers a method to reduce prescribed dose at no cost to the biological effectiveness of the treatment.

Authors:
 [1];  [2];  [3]; ; ; ;  [1];  [1]
  1. Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (United States)
  2. (Sweden)
  3. Medical Radiation Physics, Stockholm University and Karolinska Institutet, Stockholm (Sweden)
Publication Date:
OSTI Identifier:
22458681
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 91; Journal Issue: 5; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMPARATIVE EVALUATIONS; LET; PLANNING; PROTON BEAMS; RADIATION DOSES; RADIOTHERAPY

Citation Formats

Fager, Marcus, E-mail: Marcus.Fager@UPHS.UPenn.edu, Medical Radiation Physics, Stockholm University, Stockholm, Toma-Dasu, Iuliana, Kirk, Maura, Dolney, Derek, Diffenderfer, Eric S., Vapiwala, Neha, and Carabe, Alejandro, E-mail: Alejandro.Carabe-Fernandez@UPHS.UPenn.edu. Linear Energy Transfer Painting With Proton Therapy: A Means of Reducing Radiation Doses With Equivalent Clinical Effectiveness. United States: N. p., 2015. Web. doi:10.1016/J.IJROBP.2014.12.049.
Fager, Marcus, E-mail: Marcus.Fager@UPHS.UPenn.edu, Medical Radiation Physics, Stockholm University, Stockholm, Toma-Dasu, Iuliana, Kirk, Maura, Dolney, Derek, Diffenderfer, Eric S., Vapiwala, Neha, & Carabe, Alejandro, E-mail: Alejandro.Carabe-Fernandez@UPHS.UPenn.edu. Linear Energy Transfer Painting With Proton Therapy: A Means of Reducing Radiation Doses With Equivalent Clinical Effectiveness. United States. doi:10.1016/J.IJROBP.2014.12.049.
Fager, Marcus, E-mail: Marcus.Fager@UPHS.UPenn.edu, Medical Radiation Physics, Stockholm University, Stockholm, Toma-Dasu, Iuliana, Kirk, Maura, Dolney, Derek, Diffenderfer, Eric S., Vapiwala, Neha, and Carabe, Alejandro, E-mail: Alejandro.Carabe-Fernandez@UPHS.UPenn.edu. Wed . "Linear Energy Transfer Painting With Proton Therapy: A Means of Reducing Radiation Doses With Equivalent Clinical Effectiveness". United States. doi:10.1016/J.IJROBP.2014.12.049.
@article{osti_22458681,
title = {Linear Energy Transfer Painting With Proton Therapy: A Means of Reducing Radiation Doses With Equivalent Clinical Effectiveness},
author = {Fager, Marcus, E-mail: Marcus.Fager@UPHS.UPenn.edu and Medical Radiation Physics, Stockholm University, Stockholm and Toma-Dasu, Iuliana and Kirk, Maura and Dolney, Derek and Diffenderfer, Eric S. and Vapiwala, Neha and Carabe, Alejandro, E-mail: Alejandro.Carabe-Fernandez@UPHS.UPenn.edu},
abstractNote = {Purpose: The purpose of this study was to propose a proton treatment planning method that trades physical dose (D) for dose-averaged linear energy transfer (LET{sub d}) while keeping the radiobiologically weighted dose (D{sub RBE}) to the target the same. Methods and Materials: The target is painted with LET{sub d} by using 2, 4, and 7 fields aimed at the proximal segment of the target (split target planning [STP]). As the LET{sub d} within the target increases with increasing number of fields, D decreases to maintain the D{sub RBE} the same as the conventional treatment planning method by using beams treating the full target (full target planning [FTP]). Results: The LET{sub d} increased 61% for 2-field STP (2STP) compared to FTP, 72% for 4STP, and 82% for 7STP inside the target. This increase in LET{sub d} led to a decrease of D with 5.3 ± 0.6 Gy for 2STP, 4.4 ± 0.7 Gy for 4STP, and 5.3 ± 1.1 Gy for 7STP, keeping the DRBE at 90% of the volume (DRBE, 90) constant to FTP. Conclusions: LET{sub d} painting offers a method to reduce prescribed dose at no cost to the biological effectiveness of the treatment.},
doi = {10.1016/J.IJROBP.2014.12.049},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 91,
place = {United States},
year = {Wed Apr 01 00:00:00 EDT 2015},
month = {Wed Apr 01 00:00:00 EDT 2015}
}