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Title: Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring

Abstract

Formaldehyde (FA) is an environmental and occupational pollutant, and its toxic effects on the immune system have been shown. Nevertheless, no data are available regarding the programming mechanisms after FA exposure and its repercussions for the immune systems of offspring. In this study, our objective was to investigate the effects of low-dose exposure of FA on pregnant rats and its repercussion for the development of allergic lung inflammation in offspring. Pregnant Wistar rats were assigned in 3 groups: P (rats exposed to FA (0.75 ppm, 1 h/day, 5 days/week, for 21 days)), C (rats exposed to vehicle of FA (distillated water)) and B (rats non-manipulated). After 30 days of age, the offspring was sensitised with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1%, 15 min, 3 days). After 24 h the OVA challenge the parameters were evaluated. Our data showed that low-dose exposure to FA during pregnancy induced low birth weight and suppressed the development of allergic lung inflammation and tracheal hyperresponsiveness in offspring by mechanisms mediated by reduced anaphylactic antibodies synthesis, IL-6 and TNF-alpha secretion. Elevated levels of IL-10 were found. Any systemic alteration was detected in the exposed pregnant rats, although oxidative stress in the uterine environment wasmore » evident at the moment of the delivery based on elevated COX-1 expression and reduced cNOS and SOD-2 in the uterus. Therefore, we show the putative programming mechanisms induced by FA on the immune system for the first time and the mechanisms involved may be related to oxidative stress in the foetal microenvironment. - Highlights: • Formaldehyde exposure does not cause lung inflammation in pregnant rats. • Formaldehyde exposure suppresses allergic lung inflammation in the offspring. • Formaldehyde exposure induces oxidative stress in uterine environment.« less

Authors:
 [1];  [2]; ;  [3];  [2];  [3];  [1];  [1]
  1. Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo (Brazil)
  2. Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo (Brazil)
  3. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo (Brazil)
Publication Date:
OSTI Identifier:
22439798
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 278; Journal Issue: 3; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIBODIES; ASTHMA; FORMALDEHYDE; INFLAMMATION; LUNGS; LYMPHOKINES; OVA; OVALBUMIN; OXIDATION; PARTURITION; POLLUTANTS; PREGNANCY; PROGENY; RATS; SECRETION; STRESSES; SYNTHESIS; TOXICITY; UTERUS; WATER

Citation Formats

Maiellaro, Marília, Correa-Costa, Matheus, Vitoretti, Luana Beatriz, Gimenes Júnior, João Antônio, Câmara, Niels Olsen Saraiva, Tavares-de-Lima, Wothan, Farsky, Sandra Helena Poliselli, and Lino-dos-Santos-Franco, Adriana, E-mail: adrilino@usp.br. Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring. United States: N. p., 2014. Web. doi:10.1016/J.TAAP.2014.05.003.
Maiellaro, Marília, Correa-Costa, Matheus, Vitoretti, Luana Beatriz, Gimenes Júnior, João Antônio, Câmara, Niels Olsen Saraiva, Tavares-de-Lima, Wothan, Farsky, Sandra Helena Poliselli, & Lino-dos-Santos-Franco, Adriana, E-mail: adrilino@usp.br. Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring. United States. doi:10.1016/J.TAAP.2014.05.003.
Maiellaro, Marília, Correa-Costa, Matheus, Vitoretti, Luana Beatriz, Gimenes Júnior, João Antônio, Câmara, Niels Olsen Saraiva, Tavares-de-Lima, Wothan, Farsky, Sandra Helena Poliselli, and Lino-dos-Santos-Franco, Adriana, E-mail: adrilino@usp.br. Fri . "Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring". United States. doi:10.1016/J.TAAP.2014.05.003.
@article{osti_22439798,
title = {Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring},
author = {Maiellaro, Marília and Correa-Costa, Matheus and Vitoretti, Luana Beatriz and Gimenes Júnior, João Antônio and Câmara, Niels Olsen Saraiva and Tavares-de-Lima, Wothan and Farsky, Sandra Helena Poliselli and Lino-dos-Santos-Franco, Adriana, E-mail: adrilino@usp.br},
abstractNote = {Formaldehyde (FA) is an environmental and occupational pollutant, and its toxic effects on the immune system have been shown. Nevertheless, no data are available regarding the programming mechanisms after FA exposure and its repercussions for the immune systems of offspring. In this study, our objective was to investigate the effects of low-dose exposure of FA on pregnant rats and its repercussion for the development of allergic lung inflammation in offspring. Pregnant Wistar rats were assigned in 3 groups: P (rats exposed to FA (0.75 ppm, 1 h/day, 5 days/week, for 21 days)), C (rats exposed to vehicle of FA (distillated water)) and B (rats non-manipulated). After 30 days of age, the offspring was sensitised with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1%, 15 min, 3 days). After 24 h the OVA challenge the parameters were evaluated. Our data showed that low-dose exposure to FA during pregnancy induced low birth weight and suppressed the development of allergic lung inflammation and tracheal hyperresponsiveness in offspring by mechanisms mediated by reduced anaphylactic antibodies synthesis, IL-6 and TNF-alpha secretion. Elevated levels of IL-10 were found. Any systemic alteration was detected in the exposed pregnant rats, although oxidative stress in the uterine environment was evident at the moment of the delivery based on elevated COX-1 expression and reduced cNOS and SOD-2 in the uterus. Therefore, we show the putative programming mechanisms induced by FA on the immune system for the first time and the mechanisms involved may be related to oxidative stress in the foetal microenvironment. - Highlights: • Formaldehyde exposure does not cause lung inflammation in pregnant rats. • Formaldehyde exposure suppresses allergic lung inflammation in the offspring. • Formaldehyde exposure induces oxidative stress in uterine environment.},
doi = {10.1016/J.TAAP.2014.05.003},
journal = {Toxicology and Applied Pharmacology},
number = 3,
volume = 278,
place = {United States},
year = {Fri Aug 01 00:00:00 EDT 2014},
month = {Fri Aug 01 00:00:00 EDT 2014}
}