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Title: Natural Oil-Based Emulsion Containing Allantoin Versus Aqueous Cream for Managing Radiation-Induced Skin Reactions in Patients With Cancer: A Phase 3, Double-Blind, Randomized, Controlled Trial

Abstract

Purpose: To investigate the effects of a natural oil-based emulsion containing allantoin versus aqueous cream for preventing and managing radiation-induced skin reactions. Methods and Materials: A total of 174 patients were randomized and participated in the study. Patients received either cream 1 (the natural oil-based emulsion containing allantoin) or cream 2 (aqueous cream). Skin toxicity, pain, itching, and skin-related quality of life scores were collected for up to 4 weeks after radiation treatment. Results: Patients who received cream 1 had a significantly lower average level of Common Terminology Criteria for Adverse Events at week 3 (P<.05) but had statistically higher average levels of skin toxicity at weeks 7, 8, and 9 (all P<.001). Similar results were observed when skin toxicity was analyzed by grades. With regards to pain, patients in the cream 2 group had a significantly higher average level of worst pain (P<.05) and itching (P=.046) compared with the cream 1 group at week 3; however, these differences were not observed at other weeks. In addition, there was a strong trend for cream 2 to reduce the incidence of grade 2 or more skin toxicity in comparison with cream 1 (P=.056). Overall, more participants in the cream 1 group weremore » required to use another topical treatment at weeks 8 (P=.049) and 9 (P=.01). Conclusion: The natural oil-based emulsion containing allantoin seems to have similar effects for managing skin toxicity compared with aqueous cream up to week 5; however, it becomes significantly less effective at later weeks into the radiation treatment and beyond treatment completion (week 6 and beyond). There were no major differences in pain, itching, and skin-related quality of life. In light of these results, clinicians and patients can base their decision on costs and preferences. Overall, aqueous cream seems to be a more preferred option.« less

Authors:
 [1];  [2];  [2]; ; ; ; ;  [1];  [3];  [1];  [2];  [1]
  1. Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland (Australia)
  2. (Australia)
  3. National Health and Medical Research Council Centre for Research Excellence in Nursing, Centre for Health Practice Innovation–Griffith Health Institute, Griffith University, Nathan (Australia)
Publication Date:
OSTI Identifier:
22420461
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 90; Journal Issue: 4; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALLANTOIN; COMPARATIVE EVALUATIONS; EMULSIONS; NEOPLASMS; OILS; PAIN; PATIENTS; SKIN; STANDARD OF LIVING; TOXICITY

Citation Formats

Chan, Raymond Javan, E-mail: email.rchan@gmail.com, School of Nursing, Queensland University of Technology, Kelvin Grove, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Mann, Jennifer, Tripcony, Lee, Keller, Jacqui, Cheuk, Robyn, Blades, Rae, Keogh, Samantha, Poole, Christopher, Science and Engineering Faculty, Queensland University of Technology, Brisbane, and Walsh, Christopher. Natural Oil-Based Emulsion Containing Allantoin Versus Aqueous Cream for Managing Radiation-Induced Skin Reactions in Patients With Cancer: A Phase 3, Double-Blind, Randomized, Controlled Trial. United States: N. p., 2014. Web. doi:10.1016/J.IJROBP.2014.06.034.
Chan, Raymond Javan, E-mail: email.rchan@gmail.com, School of Nursing, Queensland University of Technology, Kelvin Grove, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Mann, Jennifer, Tripcony, Lee, Keller, Jacqui, Cheuk, Robyn, Blades, Rae, Keogh, Samantha, Poole, Christopher, Science and Engineering Faculty, Queensland University of Technology, Brisbane, & Walsh, Christopher. Natural Oil-Based Emulsion Containing Allantoin Versus Aqueous Cream for Managing Radiation-Induced Skin Reactions in Patients With Cancer: A Phase 3, Double-Blind, Randomized, Controlled Trial. United States. doi:10.1016/J.IJROBP.2014.06.034.
Chan, Raymond Javan, E-mail: email.rchan@gmail.com, School of Nursing, Queensland University of Technology, Kelvin Grove, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Mann, Jennifer, Tripcony, Lee, Keller, Jacqui, Cheuk, Robyn, Blades, Rae, Keogh, Samantha, Poole, Christopher, Science and Engineering Faculty, Queensland University of Technology, Brisbane, and Walsh, Christopher. Sat . "Natural Oil-Based Emulsion Containing Allantoin Versus Aqueous Cream for Managing Radiation-Induced Skin Reactions in Patients With Cancer: A Phase 3, Double-Blind, Randomized, Controlled Trial". United States. doi:10.1016/J.IJROBP.2014.06.034.
@article{osti_22420461,
title = {Natural Oil-Based Emulsion Containing Allantoin Versus Aqueous Cream for Managing Radiation-Induced Skin Reactions in Patients With Cancer: A Phase 3, Double-Blind, Randomized, Controlled Trial},
author = {Chan, Raymond Javan, E-mail: email.rchan@gmail.com and School of Nursing, Queensland University of Technology, Kelvin Grove and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove and Mann, Jennifer and Tripcony, Lee and Keller, Jacqui and Cheuk, Robyn and Blades, Rae and Keogh, Samantha and Poole, Christopher and Science and Engineering Faculty, Queensland University of Technology, Brisbane and Walsh, Christopher},
abstractNote = {Purpose: To investigate the effects of a natural oil-based emulsion containing allantoin versus aqueous cream for preventing and managing radiation-induced skin reactions. Methods and Materials: A total of 174 patients were randomized and participated in the study. Patients received either cream 1 (the natural oil-based emulsion containing allantoin) or cream 2 (aqueous cream). Skin toxicity, pain, itching, and skin-related quality of life scores were collected for up to 4 weeks after radiation treatment. Results: Patients who received cream 1 had a significantly lower average level of Common Terminology Criteria for Adverse Events at week 3 (P<.05) but had statistically higher average levels of skin toxicity at weeks 7, 8, and 9 (all P<.001). Similar results were observed when skin toxicity was analyzed by grades. With regards to pain, patients in the cream 2 group had a significantly higher average level of worst pain (P<.05) and itching (P=.046) compared with the cream 1 group at week 3; however, these differences were not observed at other weeks. In addition, there was a strong trend for cream 2 to reduce the incidence of grade 2 or more skin toxicity in comparison with cream 1 (P=.056). Overall, more participants in the cream 1 group were required to use another topical treatment at weeks 8 (P=.049) and 9 (P=.01). Conclusion: The natural oil-based emulsion containing allantoin seems to have similar effects for managing skin toxicity compared with aqueous cream up to week 5; however, it becomes significantly less effective at later weeks into the radiation treatment and beyond treatment completion (week 6 and beyond). There were no major differences in pain, itching, and skin-related quality of life. In light of these results, clinicians and patients can base their decision on costs and preferences. Overall, aqueous cream seems to be a more preferred option.},
doi = {10.1016/J.IJROBP.2014.06.034},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 90,
place = {United States},
year = {2014},
month = {11}
}