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Title: Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning

Abstract

Purpose: To investigate the feasibility of using deformable registration in clinical practice to fuse MR and CT images of the head and neck for treatment planning. Method and Materials: A state-of-the-art deformable registration algorithm was optimized, evaluated, and compared with rigid registration. The evaluation was based on manually annotated anatomic landmarks and regions of interest in both modalities. We also developed a multiparametric registration approach, which simultaneously aligns T1- and T2-weighted MR sequences to CT. This was evaluated and compared with single-parametric approaches. Results: Our results show that deformable registration yielded a better accuracy than rigid registration, without introducing unrealistic deformations. For deformable registration, an average landmark alignment of approximatively 1.7 mm was obtained. For all the regions of interest excluding the cerebellum and the parotids, deformable registration provided a median modified Hausdorff distance of approximatively 1 mm. Similar accuracies were obtained for the single-parameter and multiparameter approaches. Conclusions: This study demonstrates that deformable registration of head-and-neck CT and MR images is feasible, with overall a significanlty higher accuracy than for rigid registration.

Authors:
 [1];  [2];  [3];  [4];  [1];  [5];  [1];  [2];  [1]
  1. Biomedical Imaging Group Rotterdam, Department of Medical Informatics and Radiology, Erasmus MC University Medical Center, Rotterdam (Netherlands)
  2. Hyperthermia Unit, Department of Radiation Oncology, Erasmus MC University Medical Center Cancer Institute, Rotterdam (Netherlands)
  3. Istituto di Ricovero e Cura a Carattere Scientifico Foundation SDN for Research and High Education in Nuclear Diagnostics, Naples (Italy)
  4. Department of Radiology, Erasmus MC University Medical Center, Rotterdam (Netherlands)
  5. (Netherlands)
Publication Date:
OSTI Identifier:
22420412
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 90; Journal Issue: 1; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; ALGORITHMS; CAT SCANNING; CEREBELLUM; COMPARATIVE EVALUATIONS; DEFORMATION; HEAD; IMAGE PROCESSING; NECK; NEOPLASMS; NMR IMAGING; PLANNING

Citation Formats

Fortunati, Valerio, E-mail: v.fortunati@erasmusmc.nl, Verhaart, René F., Angeloni, Francesco, Lugt, Aad van der, Niessen, Wiro J., Faculty of Applied Sciences, Delft University of Technology, Delft, Veenland, Jifke F., Paulides, Margarethus M., and Walsum, Theo van. Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning. United States: N. p., 2014. Web. doi:10.1016/J.IJROBP.2014.05.027.
Fortunati, Valerio, E-mail: v.fortunati@erasmusmc.nl, Verhaart, René F., Angeloni, Francesco, Lugt, Aad van der, Niessen, Wiro J., Faculty of Applied Sciences, Delft University of Technology, Delft, Veenland, Jifke F., Paulides, Margarethus M., & Walsum, Theo van. Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning. United States. doi:10.1016/J.IJROBP.2014.05.027.
Fortunati, Valerio, E-mail: v.fortunati@erasmusmc.nl, Verhaart, René F., Angeloni, Francesco, Lugt, Aad van der, Niessen, Wiro J., Faculty of Applied Sciences, Delft University of Technology, Delft, Veenland, Jifke F., Paulides, Margarethus M., and Walsum, Theo van. Mon . "Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning". United States. doi:10.1016/J.IJROBP.2014.05.027.
@article{osti_22420412,
title = {Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning},
author = {Fortunati, Valerio, E-mail: v.fortunati@erasmusmc.nl and Verhaart, René F. and Angeloni, Francesco and Lugt, Aad van der and Niessen, Wiro J. and Faculty of Applied Sciences, Delft University of Technology, Delft and Veenland, Jifke F. and Paulides, Margarethus M. and Walsum, Theo van},
abstractNote = {Purpose: To investigate the feasibility of using deformable registration in clinical practice to fuse MR and CT images of the head and neck for treatment planning. Method and Materials: A state-of-the-art deformable registration algorithm was optimized, evaluated, and compared with rigid registration. The evaluation was based on manually annotated anatomic landmarks and regions of interest in both modalities. We also developed a multiparametric registration approach, which simultaneously aligns T1- and T2-weighted MR sequences to CT. This was evaluated and compared with single-parametric approaches. Results: Our results show that deformable registration yielded a better accuracy than rigid registration, without introducing unrealistic deformations. For deformable registration, an average landmark alignment of approximatively 1.7 mm was obtained. For all the regions of interest excluding the cerebellum and the parotids, deformable registration provided a median modified Hausdorff distance of approximatively 1 mm. Similar accuracies were obtained for the single-parameter and multiparameter approaches. Conclusions: This study demonstrates that deformable registration of head-and-neck CT and MR images is feasible, with overall a significanlty higher accuracy than for rigid registration.},
doi = {10.1016/J.IJROBP.2014.05.027},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 90,
place = {United States},
year = {Mon Sep 01 00:00:00 EDT 2014},
month = {Mon Sep 01 00:00:00 EDT 2014}
}