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Title: MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1

Abstract

Highlights: • MiR-132 is down-regulated in breast cancer tissues and cell lines. • MiR-132 directly regulates HN1 by binding its 3′ UTR. • MiR-132 shows regulatory role in proliferation, invasion, migration and metastasis. • HN1 is involved in miR-132-mediated cell behavior. • Aberrant HN1 is associated with worse overall survival of breast cancer patients. - Abstract: Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3′ UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novelmore » therapeutic strategy against breast cancer.« less

Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
22416823
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 454; Journal Issue: 1; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; CELL PROLIFERATION; IN VITRO; IN VIVO; INHIBITION; MAMMARY GLANDS; METASTASES; MIGRATION; NEOPLASMS; PATIENTS; RNA; TUMOR CELLS

Citation Formats

Zhang, Zhan-Guo, Chen, Wei-Xun, Wu, Yan-Hui, Liang, Hui-Fang, and Zhang, Bi-Xiang. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1. United States: N. p., 2014. Web. doi:10.1016/J.BBRC.2014.10.049.
Zhang, Zhan-Guo, Chen, Wei-Xun, Wu, Yan-Hui, Liang, Hui-Fang, & Zhang, Bi-Xiang. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1. United States. https://doi.org/10.1016/J.BBRC.2014.10.049
Zhang, Zhan-Guo, Chen, Wei-Xun, Wu, Yan-Hui, Liang, Hui-Fang, and Zhang, Bi-Xiang. 2014. "MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1". United States. https://doi.org/10.1016/J.BBRC.2014.10.049.
@article{osti_22416823,
title = {MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1},
author = {Zhang, Zhan-Guo and Chen, Wei-Xun and Wu, Yan-Hui and Liang, Hui-Fang and Zhang, Bi-Xiang},
abstractNote = {Highlights: • MiR-132 is down-regulated in breast cancer tissues and cell lines. • MiR-132 directly regulates HN1 by binding its 3′ UTR. • MiR-132 shows regulatory role in proliferation, invasion, migration and metastasis. • HN1 is involved in miR-132-mediated cell behavior. • Aberrant HN1 is associated with worse overall survival of breast cancer patients. - Abstract: Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3′ UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast cancer.},
doi = {10.1016/J.BBRC.2014.10.049},
url = {https://www.osti.gov/biblio/22416823}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 1,
volume = 454,
place = {United States},
year = {Fri Nov 07 00:00:00 EST 2014},
month = {Fri Nov 07 00:00:00 EST 2014}
}