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Title: Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

Abstract

Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed.

Authors:
 [1];  [2];  [3];  [4];  [5];  [6]; ;  [7];  [8]
  1. Department of Otorhinolaryngology—Head and Neck Surgery, Maastricht University Medical Center, Maastricht (Netherlands)
  2. Department of Otolaryngology—Head and Neck Surgery, VU University Medical Center, Amsterdam (Netherlands)
  3. Department of Head and Neck Surgery and Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)
  4. Department of Otorhinolaryngology—Head and Neck Surgery, Albert-Ludwigs-University, Freiburg, Germany and Department of Otorhinolaryngology - Head and Neck Surgery, HELIOS Hanseklinikum Stralsund, Stralsund (Germany)
  5. Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo (Spain)
  6. (Spain)
  7. ENT Clinic, University of Udine, Udine (Italy)
  8. Department of Otolaryngology—Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen (Netherlands)
Publication Date:
OSTI Identifier:
22416544
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 89; Journal Issue: 1; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BILIRUBIN; CARCINOGENS; CARCINOMAS; DNA REPAIR; ENZYMES; HEAD; MITOCHONDRIA; NECK; REVIEWS; RISK ASSESSMENT; VIRUSES

Citation Formats

Lacko, Martin, Braakhuis, Boudewijn J.M., Sturgis, Erich M., Boedeker, Carsten C., Suárez, Carlos, Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Rinaldo, Alessandra, Ferlito, Alfio, and Takes, Robert P., E-mail: robert.takes@radboudumc.nl. Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma. United States: N. p., 2014. Web. doi:10.1016/J.IJROBP.2013.09.034.
Lacko, Martin, Braakhuis, Boudewijn J.M., Sturgis, Erich M., Boedeker, Carsten C., Suárez, Carlos, Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Rinaldo, Alessandra, Ferlito, Alfio, & Takes, Robert P., E-mail: robert.takes@radboudumc.nl. Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma. United States. doi:10.1016/J.IJROBP.2013.09.034.
Lacko, Martin, Braakhuis, Boudewijn J.M., Sturgis, Erich M., Boedeker, Carsten C., Suárez, Carlos, Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Rinaldo, Alessandra, Ferlito, Alfio, and Takes, Robert P., E-mail: robert.takes@radboudumc.nl. Thu . "Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma". United States. doi:10.1016/J.IJROBP.2013.09.034.
@article{osti_22416544,
title = {Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma},
author = {Lacko, Martin and Braakhuis, Boudewijn J.M. and Sturgis, Erich M. and Boedeker, Carsten C. and Suárez, Carlos and Instituto Universitario de Oncología del Principado de Asturias, Oviedo and Rinaldo, Alessandra and Ferlito, Alfio and Takes, Robert P., E-mail: robert.takes@radboudumc.nl},
abstractNote = {Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed.},
doi = {10.1016/J.IJROBP.2013.09.034},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 1,
volume = 89,
place = {United States},
year = {2014},
month = {5}
}