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Title: Alternating current magnetic susceptibility and heat dissipation by Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} nanoparticles for hyperthermia treatment

Abstract

Mn-Zn ferrite, Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} nanoparticles encapsulated in amorphous SiO{sub 2} were prepared using our original wet chemical method. X-ray diffraction patterns confirmed that the diameters of these particles were within 7–30 nm. Magnetization measurements for various sample compositions revealed that the saturation magnetization (M{sub s}) of 7 nm particles was maximum for the x = 0.2 sample. AC magnetic susceptibility measurements were performed for Mn{sub 0.8}Zn{sub 0.2}Fe{sub 2}O{sub 4} (x = 0.2) samples with 13–30 nm particles. The peak of the imaginary part of the magnetic susceptibility χ″ shifted to higher temperatures as the particle size increased. An AC field was found to cause the increase in temperature, with the 18 nm particles exhibiting the highest temperature increase, as expected. In addition, in vitro experiments were carried out to study the hyperthermia effects of Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} (x = 0.2, 18 nm) particles on human cancer cells.

Authors:
; ; ; ;  [1]; ;  [2];  [3];  [4];  [5]; ;  [6];  [6];  [4]
  1. Department of Physics, Graduate School of Engineering, Yokohama National University, Yokohama 240-8501 (Japan)
  2. Department of Materials Science and Chemical Engineering, Graduate School of Engineering, Yokohama National University, Yokohama 240-8501 (Japan)
  3. Department of Medical Physics, Graduate School of Medicine, Tohoku University, Sendai 980-8575 (Japan)
  4. (Japan)
  5. Department of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai 980-8575 (Japan)
  6. Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai 980-8575 (Japan)
Publication Date:
OSTI Identifier:
22410077
Resource Type:
Journal Article
Journal Name:
Journal of Applied Physics
Additional Journal Information:
Journal Volume: 117; Journal Issue: 17; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0021-8979
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; ALTERNATING CURRENT; ENERGY LOSSES; FERRITES; HEAT TRANSFER; HYPERTHERMIA; IN VITRO; MAGNETIC SUSCEPTIBILITY; MAGNETIZATION; MANGANESE COMPOUNDS; NANOPARTICLES; NEOPLASMS; PARTICLE SIZE; SILICON OXIDES; THERMAL DIFFUSIVITY; THERMAL EFFLUENTS; X-RAY DIFFRACTION; ZINC COMPOUNDS

Citation Formats

Kondo, T., Mori, K., Hachisu, M., Yamazaki, T., Ichiyanagi, Y., E-mail: yuko@ynu.ac.jp, Okamoto, D., Watanabe, M., Gonda, K., Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Tada, H., Hamada, Y., Takano, M., Ohuchi, N., and Department of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai 980-8575. Alternating current magnetic susceptibility and heat dissipation by Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} nanoparticles for hyperthermia treatment. United States: N. p., 2015. Web. doi:10.1063/1.4919327.
Kondo, T., Mori, K., Hachisu, M., Yamazaki, T., Ichiyanagi, Y., E-mail: yuko@ynu.ac.jp, Okamoto, D., Watanabe, M., Gonda, K., Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Tada, H., Hamada, Y., Takano, M., Ohuchi, N., & Department of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai 980-8575. Alternating current magnetic susceptibility and heat dissipation by Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} nanoparticles for hyperthermia treatment. United States. doi:10.1063/1.4919327.
Kondo, T., Mori, K., Hachisu, M., Yamazaki, T., Ichiyanagi, Y., E-mail: yuko@ynu.ac.jp, Okamoto, D., Watanabe, M., Gonda, K., Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Tada, H., Hamada, Y., Takano, M., Ohuchi, N., and Department of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai 980-8575. Thu . "Alternating current magnetic susceptibility and heat dissipation by Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} nanoparticles for hyperthermia treatment". United States. doi:10.1063/1.4919327.
@article{osti_22410077,
title = {Alternating current magnetic susceptibility and heat dissipation by Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} nanoparticles for hyperthermia treatment},
author = {Kondo, T. and Mori, K. and Hachisu, M. and Yamazaki, T. and Ichiyanagi, Y., E-mail: yuko@ynu.ac.jp and Okamoto, D. and Watanabe, M. and Gonda, K. and Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai 980-8575 and Tada, H. and Hamada, Y. and Takano, M. and Ohuchi, N. and Department of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai 980-8575},
abstractNote = {Mn-Zn ferrite, Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} nanoparticles encapsulated in amorphous SiO{sub 2} were prepared using our original wet chemical method. X-ray diffraction patterns confirmed that the diameters of these particles were within 7–30 nm. Magnetization measurements for various sample compositions revealed that the saturation magnetization (M{sub s}) of 7 nm particles was maximum for the x = 0.2 sample. AC magnetic susceptibility measurements were performed for Mn{sub 0.8}Zn{sub 0.2}Fe{sub 2}O{sub 4} (x = 0.2) samples with 13–30 nm particles. The peak of the imaginary part of the magnetic susceptibility χ″ shifted to higher temperatures as the particle size increased. An AC field was found to cause the increase in temperature, with the 18 nm particles exhibiting the highest temperature increase, as expected. In addition, in vitro experiments were carried out to study the hyperthermia effects of Mn{sub 1−x}Zn{sub x}Fe{sub 2}O{sub 4} (x = 0.2, 18 nm) particles on human cancer cells.},
doi = {10.1063/1.4919327},
journal = {Journal of Applied Physics},
issn = {0021-8979},
number = 17,
volume = 117,
place = {United States},
year = {2015},
month = {5}
}