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Title: Microdosimetry of proton and carbon ions

Abstract

Purpose: To investigate microdosimetry properties of 160 MeV/u protons and 290 MeV/u{sup 12}C ion beams in small volumes of diameters 10–100 nm. Methods: Energy distributions of primary particles and nuclear fragments in the beams were calculated from simulations with the general purpose code SHIELD-HIT, while energy depositions by monoenergetic ions in nanometer volumes were obtained from the event-by-event Monte Carlo track structure ion code PITS99 coupled with the electron track structure code KURBUC. Results: The results are presented for frequencies of energy depositions in cylindrical targets of diameters 10–100 nm, dose distributionsyd(y) in lineal energy y, and dose-mean lineal energies y{sup ¯}{sub D}. For monoenergetic ions, the y{sup ¯}{sub D} was found to increase with an increasing target size for high-linear energy transfer (LET) ions, but decrease with an increasing target size for low-LET ions. Compared to the depth dose profile of the ion beams, the maximum of the y{sup ¯}{sub D} depth profile for the 160 MeV proton beam was located at ∼0.5 cm behind the Bragg peak maximum, while the y{sup ¯}{sub D} peak of the 290 MeV/u {sup 12}C beam coincided well with the peak of the absorbed dose profile. Differences between the y{sup ¯}{sub D} andmore » dose-averaged linear energy transfer (LET{sub D}) were large in the proton beam for both target volumes studied, and in the {sup 12}C beam for the 10 nm diameter cylindrical volumes. The y{sup ¯}{sub D} determined for 100 nm diameter cylindrical volumes in the {sup 12}C beam was approximately equal to the LET{sub D}. The contributions from secondary particles to the y{sup ¯}{sub D} of the beams are presented, including the contributions from secondary protons in the proton beam and from fragments with atomic number Z = 1–6 in the {sup 12}C beam. Conclusions: The present investigation provides an insight into differences in energy depositions in subcellular-size volumes when irradiated by proton and carbon ion beams. The results are useful for characterizing ion beams of practical importance for biophysical modeling of radiation-induced DNA damage response and repair in the depth profiles of protons and carbon ions used in radiotherapy.« less

Authors:
 [1];  [2]; ;  [3];  [4]
  1. Thailand Institute of Nuclear Technology, Ongkharak, Nakhon Nayok 26120 (Thailand)
  2. Medical Radiation Physics, Department of Physics, Stockholm University, SE-10691 (Sweden)
  3. Radiation Biophysics Group, Department of Oncology-Pathology, Karolinska Institutet, Box 260 SE-17176, Stockholm (Sweden)
  4. School of Health Sciences, Kyushu University, Fukuoka 812-8581 (Japan)
Publication Date:
OSTI Identifier:
22409576
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 8; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
07 ISOTOPES AND RADIATION SOURCES; ABSORBED RADIATION DOSES; BRAGG CURVE; CARBON 12; CARBON IONS; CYLINDRICAL CONFIGURATION; DEPTH DOSE DISTRIBUTIONS; ENERGY ABSORPTION; ENERGY LOSSES; ENERGY SPECTRA; ION BEAMS; LET; MICRODOSIMETRY; MONTE CARLO METHOD; PROTON BEAMS; RADIOTHERAPY

Citation Formats

Liamsuwan, Thiansin, Hultqvist, Martha, Lindborg, Lennart, Nikjoo, Hooshang, E-mail: hooshang.nikjoo@ki.se, and Uehara, Shuzo. Microdosimetry of proton and carbon ions. United States: N. p., 2014. Web. doi:10.1118/1.4888338.
Liamsuwan, Thiansin, Hultqvist, Martha, Lindborg, Lennart, Nikjoo, Hooshang, E-mail: hooshang.nikjoo@ki.se, & Uehara, Shuzo. Microdosimetry of proton and carbon ions. United States. doi:10.1118/1.4888338.
Liamsuwan, Thiansin, Hultqvist, Martha, Lindborg, Lennart, Nikjoo, Hooshang, E-mail: hooshang.nikjoo@ki.se, and Uehara, Shuzo. Fri . "Microdosimetry of proton and carbon ions". United States. doi:10.1118/1.4888338.
@article{osti_22409576,
title = {Microdosimetry of proton and carbon ions},
author = {Liamsuwan, Thiansin and Hultqvist, Martha and Lindborg, Lennart and Nikjoo, Hooshang, E-mail: hooshang.nikjoo@ki.se and Uehara, Shuzo},
abstractNote = {Purpose: To investigate microdosimetry properties of 160 MeV/u protons and 290 MeV/u{sup 12}C ion beams in small volumes of diameters 10–100 nm. Methods: Energy distributions of primary particles and nuclear fragments in the beams were calculated from simulations with the general purpose code SHIELD-HIT, while energy depositions by monoenergetic ions in nanometer volumes were obtained from the event-by-event Monte Carlo track structure ion code PITS99 coupled with the electron track structure code KURBUC. Results: The results are presented for frequencies of energy depositions in cylindrical targets of diameters 10–100 nm, dose distributionsyd(y) in lineal energy y, and dose-mean lineal energies y{sup ¯}{sub D}. For monoenergetic ions, the y{sup ¯}{sub D} was found to increase with an increasing target size for high-linear energy transfer (LET) ions, but decrease with an increasing target size for low-LET ions. Compared to the depth dose profile of the ion beams, the maximum of the y{sup ¯}{sub D} depth profile for the 160 MeV proton beam was located at ∼0.5 cm behind the Bragg peak maximum, while the y{sup ¯}{sub D} peak of the 290 MeV/u {sup 12}C beam coincided well with the peak of the absorbed dose profile. Differences between the y{sup ¯}{sub D} and dose-averaged linear energy transfer (LET{sub D}) were large in the proton beam for both target volumes studied, and in the {sup 12}C beam for the 10 nm diameter cylindrical volumes. The y{sup ¯}{sub D} determined for 100 nm diameter cylindrical volumes in the {sup 12}C beam was approximately equal to the LET{sub D}. The contributions from secondary particles to the y{sup ¯}{sub D} of the beams are presented, including the contributions from secondary protons in the proton beam and from fragments with atomic number Z = 1–6 in the {sup 12}C beam. Conclusions: The present investigation provides an insight into differences in energy depositions in subcellular-size volumes when irradiated by proton and carbon ion beams. The results are useful for characterizing ion beams of practical importance for biophysical modeling of radiation-induced DNA damage response and repair in the depth profiles of protons and carbon ions used in radiotherapy.},
doi = {10.1118/1.4888338},
journal = {Medical Physics},
number = 8,
volume = 41,
place = {United States},
year = {Fri Aug 15 00:00:00 EDT 2014},
month = {Fri Aug 15 00:00:00 EDT 2014}
}