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Title: Sci—Thur AM: YIS - 08: Constructing an Attenuation map for a PET/MR Breast coil

Abstract

In 2013, around 23000 Canadian women and 200 Canadian men were diagnosed with breast cancer. An estimated 5100 women and 55 men died from the disease. Using the sensitivity of MRI with the selectivity of PET, PET/MRI combines anatomical and functional information within the same scan and could help with early detection in high-risk patients. MRI requires radiofrequency coils for transmitting energy and receiving signal but the breast coil attenuates PET signal. To correct for this PET attenuation, a 3-dimensional map of linear attenuation coefficients (μ-map) of the breast coil must be created and incorporated into the PET reconstruction process. Several approaches have been proposed for building hardware μ-maps, some of which include the use of conventional kVCT and Dual energy CT. These methods can produce high resolution images based on the electron densities of materials that can be converted into μ-maps. However, imaging hardware containing metal components with photons in the kV range is susceptible to metal artifacts. These artifacts can compromise the accuracy of the resulting μ-map and PET reconstruction; therefore high-Z components should be removed. We propose a method for calculating μ-maps without removing coil components, based on megavoltage (MV) imaging with a linear accelerator that hasmore » been detuned for imaging at 1.0MeV. Containers of known geometry with F18 were placed in the breast coil for imaging. A comparison between reconstructions based on the different μ-map construction methods was made. PET reconstructions with our method show a maximum of 6% difference over the existing kVCT-based reconstructions.« less

Authors:
 [1];  [2];  [2];  [1];  [2];  [2];  [3];  [4];  [1];  [2];  [2];  [1];  [2];  [1];  [2];  [2];  [1];  [2];  [2];  [2]
  1. Department of Medical Biophysics, Western University, Knoxville, TN (United States)
  2. (United States)
  3. Imaging, Lawson Health Research Institute, Knoxville, TN (United States)
  4. Siemens Healthcare Molecular Imaging, Knoxville, TN (United States)
Publication Date:
OSTI Identifier:
22409504
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 8; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ACCURACY; CANADA; COMPARATIVE EVALUATIONS; GEOMETRY; MAMMARY GLANDS; MEN; NEOPLASMS; NMR IMAGING; POSITRON COMPUTED TOMOGRAPHY; THREE-DIMENSIONAL CALCULATIONS; WOMEN

Citation Formats

Patrick, John C., Imaging, Lawson Health Research Institute, Knoxville, TN, London Regional Cancer Program, Knoxville, TN, So, Aaron, Imaging, Lawson Health Research Institute, Knoxville, TN, Imaging Laboratories - Robarts Research Institute, Knoxville, TN, Butler, John, Faul, David, Yartsev, Slav, Department of Oncology, Western University, Knoxville, TN, London Regional Cancer Program, Knoxville, TN, Thompson, Terry, Imaging, Lawson Health Research Institute, Knoxville, TN, Prato, Frank S., Imaging, Lawson Health Research Institute, Knoxville, TN, Diagnostic Imaging St Joseph's Health Care London, Knoxville, TN, Gaede, Stewart, Department of Oncology, Western University, Knoxville, TN, Imaging, Lawson Health Research Institute, Knoxville, TN, and London Regional Cancer Program, Knoxville, TN. Sci—Thur AM: YIS - 08: Constructing an Attenuation map for a PET/MR Breast coil. United States: N. p., 2014. Web. doi:10.1118/1.4894949.
Patrick, John C., Imaging, Lawson Health Research Institute, Knoxville, TN, London Regional Cancer Program, Knoxville, TN, So, Aaron, Imaging, Lawson Health Research Institute, Knoxville, TN, Imaging Laboratories - Robarts Research Institute, Knoxville, TN, Butler, John, Faul, David, Yartsev, Slav, Department of Oncology, Western University, Knoxville, TN, London Regional Cancer Program, Knoxville, TN, Thompson, Terry, Imaging, Lawson Health Research Institute, Knoxville, TN, Prato, Frank S., Imaging, Lawson Health Research Institute, Knoxville, TN, Diagnostic Imaging St Joseph's Health Care London, Knoxville, TN, Gaede, Stewart, Department of Oncology, Western University, Knoxville, TN, Imaging, Lawson Health Research Institute, Knoxville, TN, & London Regional Cancer Program, Knoxville, TN. Sci—Thur AM: YIS - 08: Constructing an Attenuation map for a PET/MR Breast coil. United States. doi:10.1118/1.4894949.
Patrick, John C., Imaging, Lawson Health Research Institute, Knoxville, TN, London Regional Cancer Program, Knoxville, TN, So, Aaron, Imaging, Lawson Health Research Institute, Knoxville, TN, Imaging Laboratories - Robarts Research Institute, Knoxville, TN, Butler, John, Faul, David, Yartsev, Slav, Department of Oncology, Western University, Knoxville, TN, London Regional Cancer Program, Knoxville, TN, Thompson, Terry, Imaging, Lawson Health Research Institute, Knoxville, TN, Prato, Frank S., Imaging, Lawson Health Research Institute, Knoxville, TN, Diagnostic Imaging St Joseph's Health Care London, Knoxville, TN, Gaede, Stewart, Department of Oncology, Western University, Knoxville, TN, Imaging, Lawson Health Research Institute, Knoxville, TN, and London Regional Cancer Program, Knoxville, TN. Fri . "Sci—Thur AM: YIS - 08: Constructing an Attenuation map for a PET/MR Breast coil". United States. doi:10.1118/1.4894949.
@article{osti_22409504,
title = {Sci—Thur AM: YIS - 08: Constructing an Attenuation map for a PET/MR Breast coil},
author = {Patrick, John C. and Imaging, Lawson Health Research Institute, Knoxville, TN and London Regional Cancer Program, Knoxville, TN and So, Aaron and Imaging, Lawson Health Research Institute, Knoxville, TN and Imaging Laboratories - Robarts Research Institute, Knoxville, TN and Butler, John and Faul, David and Yartsev, Slav and Department of Oncology, Western University, Knoxville, TN and London Regional Cancer Program, Knoxville, TN and Thompson, Terry and Imaging, Lawson Health Research Institute, Knoxville, TN and Prato, Frank S. and Imaging, Lawson Health Research Institute, Knoxville, TN and Diagnostic Imaging St Joseph's Health Care London, Knoxville, TN and Gaede, Stewart and Department of Oncology, Western University, Knoxville, TN and Imaging, Lawson Health Research Institute, Knoxville, TN and London Regional Cancer Program, Knoxville, TN},
abstractNote = {In 2013, around 23000 Canadian women and 200 Canadian men were diagnosed with breast cancer. An estimated 5100 women and 55 men died from the disease. Using the sensitivity of MRI with the selectivity of PET, PET/MRI combines anatomical and functional information within the same scan and could help with early detection in high-risk patients. MRI requires radiofrequency coils for transmitting energy and receiving signal but the breast coil attenuates PET signal. To correct for this PET attenuation, a 3-dimensional map of linear attenuation coefficients (μ-map) of the breast coil must be created and incorporated into the PET reconstruction process. Several approaches have been proposed for building hardware μ-maps, some of which include the use of conventional kVCT and Dual energy CT. These methods can produce high resolution images based on the electron densities of materials that can be converted into μ-maps. However, imaging hardware containing metal components with photons in the kV range is susceptible to metal artifacts. These artifacts can compromise the accuracy of the resulting μ-map and PET reconstruction; therefore high-Z components should be removed. We propose a method for calculating μ-maps without removing coil components, based on megavoltage (MV) imaging with a linear accelerator that has been detuned for imaging at 1.0MeV. Containers of known geometry with F18 were placed in the breast coil for imaging. A comparison between reconstructions based on the different μ-map construction methods was made. PET reconstructions with our method show a maximum of 6% difference over the existing kVCT-based reconstructions.},
doi = {10.1118/1.4894949},
journal = {Medical Physics},
number = 8,
volume = 41,
place = {United States},
year = {Fri Aug 15 00:00:00 EDT 2014},
month = {Fri Aug 15 00:00:00 EDT 2014}
}