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Title: Detection of endotoxin using a photonic crystal nanolaser

Abstract

Fast and reliable detection of endotoxin (ET) in medical equipment and pharmaceutical products is an essential precursor to clinical treatment. In this study, we demonstrate the use of shifts in wavelength of photonic crystal nanolasers for sensing the Limulus amebocyte lysate reaction, which is a standard method for detecting ET. From working curves of wavelength shift vs ET concentration, whose correlation factors were as high as 98%, we detected a required concentration of 0.001 EU/ml within 33 min and detected a low concentration of 0.0001 EU/ml.

Authors:
; ; ; ;  [1]
  1. Department of Electrical and Computer Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501 (Japan)
Publication Date:
OSTI Identifier:
22398806
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 106; Journal Issue: 13; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ABUNDANCE; CONCENTRATION RATIO; CORRELATIONS; CRYSTALS; DETECTION; DIAGRAMS; LASERS; PHOTONS; PRECURSOR; TOXINS; WAVELENGTHS

Citation Formats

Takahashi, Daichi, Hachuda, Shoji, Watanabe, Takumi, Nishijima, Yoshiaki, and Baba, Toshihiko, E-mail: baba@ynu.ac.jp. Detection of endotoxin using a photonic crystal nanolaser. United States: N. p., 2015. Web. doi:10.1063/1.4916921.
Takahashi, Daichi, Hachuda, Shoji, Watanabe, Takumi, Nishijima, Yoshiaki, & Baba, Toshihiko, E-mail: baba@ynu.ac.jp. Detection of endotoxin using a photonic crystal nanolaser. United States. doi:10.1063/1.4916921.
Takahashi, Daichi, Hachuda, Shoji, Watanabe, Takumi, Nishijima, Yoshiaki, and Baba, Toshihiko, E-mail: baba@ynu.ac.jp. Mon . "Detection of endotoxin using a photonic crystal nanolaser". United States. doi:10.1063/1.4916921.
@article{osti_22398806,
title = {Detection of endotoxin using a photonic crystal nanolaser},
author = {Takahashi, Daichi and Hachuda, Shoji and Watanabe, Takumi and Nishijima, Yoshiaki and Baba, Toshihiko, E-mail: baba@ynu.ac.jp},
abstractNote = {Fast and reliable detection of endotoxin (ET) in medical equipment and pharmaceutical products is an essential precursor to clinical treatment. In this study, we demonstrate the use of shifts in wavelength of photonic crystal nanolasers for sensing the Limulus amebocyte lysate reaction, which is a standard method for detecting ET. From working curves of wavelength shift vs ET concentration, whose correlation factors were as high as 98%, we detected a required concentration of 0.001 EU/ml within 33 min and detected a low concentration of 0.0001 EU/ml.},
doi = {10.1063/1.4916921},
journal = {Applied Physics Letters},
number = 13,
volume = 106,
place = {United States},
year = {Mon Mar 30 00:00:00 EDT 2015},
month = {Mon Mar 30 00:00:00 EDT 2015}
}