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Title: A frequency and amplitude scanned quadrupole mass filter for the analysis of high m/z ions

Abstract

Quadrupole mass filters (QMFs) are usually not used to analyze high m/z ions, due to the low frequency resonant circuit that is required to drive them. Here we describe a new approach to generating waveforms for QMFs. Instead of scanning the amplitude of a sine wave to measure the m/z spectrum, the frequency of a trapezoidal wave is digitally scanned. A synchronous, narrow-range (<0.2%) amplitude scan overlays the frequency scan to improve the sampling resolution. Because the frequency is the primary quantity that is scanned, there is, in principle, no upper m/z limit. The frequency signal is constructed from a stabilized base clock using a field programmable gate array. This signal drives integrating amplifiers which generate the trapezoidal waves. For a trapezoidal wave the harmonics can be minimized by selecting the appropriate rise and fall times. To achieve a high resolving power, the digital signal has low jitter, and the trapezoidal waveform is generated with high fidelity. The QMF was characterized with cesium iodide clusters. Singly and multiply charged clusters with z up to +5 were observed. A resolving power of ∼1200 (FWHM) was demonstrated over a broad m/z range. Resolution was lost above 20 000 Th, partly because of congestionmore » due to overlapping multiply charged clusters. Ions were observed for m/z values well in excess of 150 000 Th.« less

Authors:
; ; ; ;  [1]
  1. Department of Chemistry, Indiana University, 800 East Kirkwood Ave., Bloomington, Indiana 47405 (United States)
Publication Date:
OSTI Identifier:
22392221
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 85; Journal Issue: 11; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; AMPLIFIERS; AMPLITUDES; CESIUM IODIDES; FILTERS; HARMONICS; IONS; MASS; RESOLUTION; SAMPLING; SIGNALS; SPECTRA; WAVE FORMS

Citation Formats

Shinholt, Deven L., Anthony, Staci N., Alexander, Andrew W., Draper, Benjamin E., and Jarrold, Martin F. A frequency and amplitude scanned quadrupole mass filter for the analysis of high m/z ions. United States: N. p., 2014. Web. doi:10.1063/1.4900627.
Shinholt, Deven L., Anthony, Staci N., Alexander, Andrew W., Draper, Benjamin E., & Jarrold, Martin F. A frequency and amplitude scanned quadrupole mass filter for the analysis of high m/z ions. United States. doi:10.1063/1.4900627.
Shinholt, Deven L., Anthony, Staci N., Alexander, Andrew W., Draper, Benjamin E., and Jarrold, Martin F. Sat . "A frequency and amplitude scanned quadrupole mass filter for the analysis of high m/z ions". United States. doi:10.1063/1.4900627.
@article{osti_22392221,
title = {A frequency and amplitude scanned quadrupole mass filter for the analysis of high m/z ions},
author = {Shinholt, Deven L. and Anthony, Staci N. and Alexander, Andrew W. and Draper, Benjamin E. and Jarrold, Martin F.},
abstractNote = {Quadrupole mass filters (QMFs) are usually not used to analyze high m/z ions, due to the low frequency resonant circuit that is required to drive them. Here we describe a new approach to generating waveforms for QMFs. Instead of scanning the amplitude of a sine wave to measure the m/z spectrum, the frequency of a trapezoidal wave is digitally scanned. A synchronous, narrow-range (<0.2%) amplitude scan overlays the frequency scan to improve the sampling resolution. Because the frequency is the primary quantity that is scanned, there is, in principle, no upper m/z limit. The frequency signal is constructed from a stabilized base clock using a field programmable gate array. This signal drives integrating amplifiers which generate the trapezoidal waves. For a trapezoidal wave the harmonics can be minimized by selecting the appropriate rise and fall times. To achieve a high resolving power, the digital signal has low jitter, and the trapezoidal waveform is generated with high fidelity. The QMF was characterized with cesium iodide clusters. Singly and multiply charged clusters with z up to +5 were observed. A resolving power of ∼1200 (FWHM) was demonstrated over a broad m/z range. Resolution was lost above 20 000 Th, partly because of congestion due to overlapping multiply charged clusters. Ions were observed for m/z values well in excess of 150 000 Th.},
doi = {10.1063/1.4900627},
journal = {Review of Scientific Instruments},
number = 11,
volume = 85,
place = {United States},
year = {Sat Nov 15 00:00:00 EST 2014},
month = {Sat Nov 15 00:00:00 EST 2014}
}
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