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Title: Inhibition of brain tumor cell proliferation by alternating electric fields

Abstract

This study was designed to investigate the mechanism by which electric fields affect cell function, and to determine the optimal conditions for electric field inhibition of cancer cell proliferation. Low-intensity (<2 V/cm) and intermediate-frequency (100–300 kHz) alternating electric fields were applied to glioblastoma cell lines. These electric fields inhibited cell proliferation by inducing cell cycle arrest and abnormal mitosis due to the malformation of microtubules. These effects were significantly dependent on the intensity and frequency of applied electric fields.

Authors:
; ;  [1]; ; ;  [2];  [3]
  1. School of Biosystem and Biomedical Science, Korea University, Seoul 136-703 (Korea, Republic of)
  2. Department of Bio-convergence Engineering, Korea University, Seoul 136-703 (Korea, Republic of)
  3. Seoul Center, Korea Basic Science Institute, Seoul 136-713 (Korea, Republic of)
Publication Date:
OSTI Identifier:
22392044
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 105; Journal Issue: 20; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BRAIN; CELL PROLIFERATION; ELECTRIC FIELDS; GLIOMAS; INHIBITION; KHZ RANGE 100-1000; MALFORMATIONS; MICROTUBULES; TUMOR CELLS

Citation Formats

Jeong, Hyesun, Oh, Seung-ick, Hong, Sunghoi, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr, Sung, Jiwon, Jeong, Seonghoon, Yoon, Myonggeun, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr, and Koh, Eui Kwan. Inhibition of brain tumor cell proliferation by alternating electric fields. United States: N. p., 2014. Web. doi:10.1063/1.4902112.
Jeong, Hyesun, Oh, Seung-ick, Hong, Sunghoi, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr, Sung, Jiwon, Jeong, Seonghoon, Yoon, Myonggeun, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr, & Koh, Eui Kwan. Inhibition of brain tumor cell proliferation by alternating electric fields. United States. doi:10.1063/1.4902112.
Jeong, Hyesun, Oh, Seung-ick, Hong, Sunghoi, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr, Sung, Jiwon, Jeong, Seonghoon, Yoon, Myonggeun, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr, and Koh, Eui Kwan. Mon . "Inhibition of brain tumor cell proliferation by alternating electric fields". United States. doi:10.1063/1.4902112.
@article{osti_22392044,
title = {Inhibition of brain tumor cell proliferation by alternating electric fields},
author = {Jeong, Hyesun and Oh, Seung-ick and Hong, Sunghoi, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr and Sung, Jiwon and Jeong, Seonghoon and Yoon, Myonggeun, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr and Koh, Eui Kwan},
abstractNote = {This study was designed to investigate the mechanism by which electric fields affect cell function, and to determine the optimal conditions for electric field inhibition of cancer cell proliferation. Low-intensity (<2 V/cm) and intermediate-frequency (100–300 kHz) alternating electric fields were applied to glioblastoma cell lines. These electric fields inhibited cell proliferation by inducing cell cycle arrest and abnormal mitosis due to the malformation of microtubules. These effects were significantly dependent on the intensity and frequency of applied electric fields.},
doi = {10.1063/1.4902112},
journal = {Applied Physics Letters},
number = 20,
volume = 105,
place = {United States},
year = {Mon Nov 17 00:00:00 EST 2014},
month = {Mon Nov 17 00:00:00 EST 2014}
}