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Title: Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications

Abstract

Highly porous three-dimensional polylactide (PLA) scaffolds were obtained from PLA incorporated with different amounts of chitosan-modified montmorillonite (CS-MMT), through solvent casting and particulate leaching method. The processed scaffolds were tested in vitro for their possible application in bone tissue engineering. Scaffolds were characterized by Focused Ion Beam Scanning Electron Microscopy (FIB SEM), Fourier Transform Infra-Red (FTIR), and X-Ray Diffraction (XRD) to study their structure and intermolecular interactions. Bioresorbability tests in simulated body fluid (pH 7.4) were conducted to assess the response of the scaffolds in a simulated physiological condition. The FIB SEM images of the scaffolds showed a porous architecture with gradual change in morphology with increasing CS-MMT concentration. FTIR analysis revealed the presence of both PLA and CS-MMT particles on the surface of the scaffolds. XRD showed that the crystalline unit cell type was the same for all the scaffolds, and crystallinity decreased with an increase in CS-MMT concentration. The scaffolds were found to be bioresorbable, with rapid bioresorbability on the scaffolds with a high CS-MMT concentration.

Authors:
;  [1];  [2]
  1. Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028 (South Africa)
  2. (South Africa)
Publication Date:
OSTI Identifier:
22391860
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1664; Journal Issue: 1; Conference: PPS-30: 30. International Conference of the Polymer Processing Society, Cleveland, OH (United States), 6-12 Jun 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; AMINO ACIDS; BODY FLUIDS; BONE TISSUES; CASTING; CONCENTRATION RATIO; FOURIER TRANSFORMATION; INFRARED SPECTRA; ION BEAMS; MONTMORILLONITE; MORPHOLOGY; OLIGOSACCHARIDES; PARTICLES; POROUS MATERIALS; SCANNING ELECTRON MICROSCOPY; X-RAY DIFFRACTION

Citation Formats

Mkhabela, Vuyiswa J., Ray, Suprakas Sinha, and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001. Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications. United States: N. p., 2015. Web. doi:10.1063/1.4918444.
Mkhabela, Vuyiswa J., Ray, Suprakas Sinha, & DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001. Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications. United States. doi:10.1063/1.4918444.
Mkhabela, Vuyiswa J., Ray, Suprakas Sinha, and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001. Fri . "Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications". United States. doi:10.1063/1.4918444.
@article{osti_22391860,
title = {Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications},
author = {Mkhabela, Vuyiswa J. and Ray, Suprakas Sinha and DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001},
abstractNote = {Highly porous three-dimensional polylactide (PLA) scaffolds were obtained from PLA incorporated with different amounts of chitosan-modified montmorillonite (CS-MMT), through solvent casting and particulate leaching method. The processed scaffolds were tested in vitro for their possible application in bone tissue engineering. Scaffolds were characterized by Focused Ion Beam Scanning Electron Microscopy (FIB SEM), Fourier Transform Infra-Red (FTIR), and X-Ray Diffraction (XRD) to study their structure and intermolecular interactions. Bioresorbability tests in simulated body fluid (pH 7.4) were conducted to assess the response of the scaffolds in a simulated physiological condition. The FIB SEM images of the scaffolds showed a porous architecture with gradual change in morphology with increasing CS-MMT concentration. FTIR analysis revealed the presence of both PLA and CS-MMT particles on the surface of the scaffolds. XRD showed that the crystalline unit cell type was the same for all the scaffolds, and crystallinity decreased with an increase in CS-MMT concentration. The scaffolds were found to be bioresorbable, with rapid bioresorbability on the scaffolds with a high CS-MMT concentration.},
doi = {10.1063/1.4918444},
journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1664,
place = {United States},
year = {2015},
month = {5}
}