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Title: Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives

Abstract

Metallic nanoparticles increase the delivered dose and consequently enhance tissue radio sensitization during radiation therapy of cancer. The Dose Enhancement Factor (DEF) corresponds to the ratio between the dose deposited on a tissue containing nanoparticles, and the dose deposited on a tissue without nanoparticles. In this sense, we have used electron spin resonance spectroscopy (ESR) to investigate how silver and gold nanoparticles affect the dose deposition in alanine dosimeters, which act as a surrogate of soft tissue. Besides optimizing radiation absorption by the dosimeter, the optical properties of these metal nanoparticles could also improve light emission from materials employed as radiation detectors. Therefore, we have also examined how the plasmonic properties of noble metal nanoparticles could enhance radiation detection using optically stimulated luminescence (OSL) dosimetry. This work will show results on how the use of gold and silver nanoparticles are beneficial for the ESR and OSL dosimetric techniques, and will describe the difficulties we have been facing, the challenges to overcome, and the perspectives.

Authors:
 [1]
  1. Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP (Brazil)
Publication Date:
OSTI Identifier:
22390523
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1626; Journal Issue: 1; Conference: 13. Mexican Symposium on Medical Physics, Leon, Guanajuato (Mexico), 15-16 Mar 2014; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 61 RADIATION PROTECTION AND DOSIMETRY; ABSORPTION; ALANINES; ANIMAL TISSUES; DOSEMETERS; DOSIMETRY; ELECTRON SPIN RESONANCE; EMISSION SPECTROSCOPY; GOLD; LUMINESCENCE; NANOPARTICLES; NEOPLASMS; OPTICAL PROPERTIES; RADIATION DETECTION; RADIOTHERAPY; SILVER; VISIBLE RADIATION

Citation Formats

Guidelli, Eder José, E-mail: ederguidelli@pg.ffclrp.usp.br, and Baffa, Oswaldo. Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives. United States: N. p., 2014. Web. doi:10.1063/1.4901354.
Guidelli, Eder José, E-mail: ederguidelli@pg.ffclrp.usp.br, & Baffa, Oswaldo. Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives. United States. https://doi.org/10.1063/1.4901354
Guidelli, Eder José, E-mail: ederguidelli@pg.ffclrp.usp.br, and Baffa, Oswaldo. 2014. "Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives". United States. https://doi.org/10.1063/1.4901354.
@article{osti_22390523,
title = {Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives},
author = {Guidelli, Eder José, E-mail: ederguidelli@pg.ffclrp.usp.br and Baffa, Oswaldo},
abstractNote = {Metallic nanoparticles increase the delivered dose and consequently enhance tissue radio sensitization during radiation therapy of cancer. The Dose Enhancement Factor (DEF) corresponds to the ratio between the dose deposited on a tissue containing nanoparticles, and the dose deposited on a tissue without nanoparticles. In this sense, we have used electron spin resonance spectroscopy (ESR) to investigate how silver and gold nanoparticles affect the dose deposition in alanine dosimeters, which act as a surrogate of soft tissue. Besides optimizing radiation absorption by the dosimeter, the optical properties of these metal nanoparticles could also improve light emission from materials employed as radiation detectors. Therefore, we have also examined how the plasmonic properties of noble metal nanoparticles could enhance radiation detection using optically stimulated luminescence (OSL) dosimetry. This work will show results on how the use of gold and silver nanoparticles are beneficial for the ESR and OSL dosimetric techniques, and will describe the difficulties we have been facing, the challenges to overcome, and the perspectives.},
doi = {10.1063/1.4901354},
url = {https://www.osti.gov/biblio/22390523}, journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1626,
place = {United States},
year = {Fri Nov 07 00:00:00 EST 2014},
month = {Fri Nov 07 00:00:00 EST 2014}
}