skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Collaborative Computational Project for Electron cryo-Microscopy

Journal Article · · Acta Crystallographica. Section D: Biological Crystallography
;  [1];  [2];  [3];  [4];  [5];  [6]
  1. Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA (United Kingdom)
  2. European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD (United Kingdom)
  3. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (United Kingdom)
  4. University of London, Malet Street, London WC1E 7HX (United Kingdom)
  5. University of Manchester, Oxford Road, Manchester M13 9PT (United Kingdom)
  6. Science and Technology Facilities Council, Daresbury Laboratory, Warrington WA4 4AD (United Kingdom)

The Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) is a new initiative for the structural biology community, following the success of CCP4 for macromolecular crystallography. Progress in supporting the users and developers of cryoEM software is reported. The Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has recently been established. The aims of the project are threefold: to build a coherent cryoEM community which will provide support for individual scientists and will act as a focal point for liaising with other communities, to support practising scientists in their use of cryoEM software and finally to support software developers in producing and disseminating robust and user-friendly programs. The project is closely modelled on CCP4 for macromolecular crystallography, and areas of common interest such as model fitting, underlying software libraries and tools for building program packages are being exploited. Nevertheless, cryoEM includes a number of techniques covering a large range of resolutions and a distinct project is required. In this article, progress so far is reported and future plans are discussed.

OSTI ID:
22347704
Journal Information:
Acta Crystallographica. Section D: Biological Crystallography, Vol. 71, Issue Pt 1; Other Information: PMCID: PMC4304692; PMID: 25615866; PUBLISHER-ID: gm5035; OAI: oai:pubmedcentral.nih.gov:4304692; Copyright (c) Wood et al. 2015; This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0907-4449
Country of Publication:
Denmark
Language:
English

Similar Records

Evolving data standards for cryo-EM structures
Journal Article · Fri Jan 24 00:00:00 EST 2020 · Structural Dynamics · OSTI ID:22347704

Atomistic modelling of scattering data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS)
Journal Article · Fri Oct 14 00:00:00 EDT 2016 · Journal of Applied Crystallography (Online) · OSTI ID:22347704

A national facility for biological cryo-electron microscopy
Journal Article · Thu Jan 01 00:00:00 EST 2015 · Acta Crystallographica. Section D: Biological Crystallography · OSTI ID:22347704