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Title: SU-D-BRE-02: Development and Commissioning of A Gated Spot Scanning Proton Beam Therapy System with Real-Time Tumor-Tracking

Abstract

Purpose: A novel Proton Beam Therapy system has been developed by integrating Real-Time Tumor-Tracking (RTRT) and discrete spot scanning techniques. The system dedicated for spot scanning delivers significant advantages for both clinical and economical points of view. The system has the ability to control dose distribution with spot scanning beams and to gate the beams from the synchrotron to irradiate moving tumors only when the actual positions of them are within the planned position. Methods: The newly designed system consists of a synchrotron, beam transport systems, a compact and rotating gantry system with robotic couch and two orthogonal sets of X-ray fluoroscopes. The fully compact design of the system has been realized by reducing the maximum energy of the beam to 220MeV, corresponding to 30g/cm2 range and the number of circulating protons per synchrotron operation cycle, due to higher beam utilization efficiency in spot scanning. To improve the irradiation efficiency in the integration of RTRT and spot scanning, a new control system has been developed to enable multiple gated irradiation per operation cycle according to the gating signals. After the completion of the equipment installation, beam tests and commissioning has been successfully performed. Results: The basic performances and beam characteristicsmore » through the synchrotron accelerator to iso-center have been confirmed and the performance test of the irradiation nozzle and whole system has been appropriately completed. CBCT image has been checked and sufficient quality was obtained. RTRT system has been demonstrated and realized accurate dose distributions for moving targets. Conclusion: The gated spot scanning Proton Beam Therapy system with Real-Time Tumor-Tracking has been developed, successfully installed and tested. The new system enables us to deliver higher dose to the moving target tumors while sparing surrounding normal tissues and to realize the compact design of the system and facility by maximizing the efficiency of proton beam utilization. This research is granted by the Japan Society for the Promotion of Science(JSPS) through the “Funding Program for World-Leading Innovative R and D on Science and Technology(FIRST Program)”, initiated by the Council for Science and Technology Policy(CSTP)« less

Authors:
; ; ; ; ; ; ;  [1]; ; ; ;  [2]
  1. Hokkaido University, Sapporo, Hokkaido (Japan)
  2. Hitachi, Ltd., Chiyoda-ku, Tokyo (Japan)
Publication Date:
OSTI Identifier:
22333978
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 41; Journal Issue: 6; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; COMMISSIONING; CONTROL SYSTEMS; IMAGES; IRRADIATION; NEOPLASMS; PERFORMANCE; PROTON BEAMS; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIOTHERAPY; SYNCHROTRONS

Citation Formats

Umegaki, K, Matsuura, T., Takao, S., Nihongi, H., Yamada, T., Miyamoto, N., Shimizu, S., Shirato, H., Matsuda, K., Nakamura, F., Umezawa, M., and Hiramoto, K. SU-D-BRE-02: Development and Commissioning of A Gated Spot Scanning Proton Beam Therapy System with Real-Time Tumor-Tracking. United States: N. p., 2014. Web. doi:10.1118/1.4887872.
Umegaki, K, Matsuura, T., Takao, S., Nihongi, H., Yamada, T., Miyamoto, N., Shimizu, S., Shirato, H., Matsuda, K., Nakamura, F., Umezawa, M., & Hiramoto, K. SU-D-BRE-02: Development and Commissioning of A Gated Spot Scanning Proton Beam Therapy System with Real-Time Tumor-Tracking. United States. https://doi.org/10.1118/1.4887872
Umegaki, K, Matsuura, T., Takao, S., Nihongi, H., Yamada, T., Miyamoto, N., Shimizu, S., Shirato, H., Matsuda, K., Nakamura, F., Umezawa, M., and Hiramoto, K. 2014. "SU-D-BRE-02: Development and Commissioning of A Gated Spot Scanning Proton Beam Therapy System with Real-Time Tumor-Tracking". United States. https://doi.org/10.1118/1.4887872.
@article{osti_22333978,
title = {SU-D-BRE-02: Development and Commissioning of A Gated Spot Scanning Proton Beam Therapy System with Real-Time Tumor-Tracking},
author = {Umegaki, K and Matsuura, T. and Takao, S. and Nihongi, H. and Yamada, T. and Miyamoto, N. and Shimizu, S. and Shirato, H. and Matsuda, K. and Nakamura, F. and Umezawa, M. and Hiramoto, K.},
abstractNote = {Purpose: A novel Proton Beam Therapy system has been developed by integrating Real-Time Tumor-Tracking (RTRT) and discrete spot scanning techniques. The system dedicated for spot scanning delivers significant advantages for both clinical and economical points of view. The system has the ability to control dose distribution with spot scanning beams and to gate the beams from the synchrotron to irradiate moving tumors only when the actual positions of them are within the planned position. Methods: The newly designed system consists of a synchrotron, beam transport systems, a compact and rotating gantry system with robotic couch and two orthogonal sets of X-ray fluoroscopes. The fully compact design of the system has been realized by reducing the maximum energy of the beam to 220MeV, corresponding to 30g/cm2 range and the number of circulating protons per synchrotron operation cycle, due to higher beam utilization efficiency in spot scanning. To improve the irradiation efficiency in the integration of RTRT and spot scanning, a new control system has been developed to enable multiple gated irradiation per operation cycle according to the gating signals. After the completion of the equipment installation, beam tests and commissioning has been successfully performed. Results: The basic performances and beam characteristics through the synchrotron accelerator to iso-center have been confirmed and the performance test of the irradiation nozzle and whole system has been appropriately completed. CBCT image has been checked and sufficient quality was obtained. RTRT system has been demonstrated and realized accurate dose distributions for moving targets. Conclusion: The gated spot scanning Proton Beam Therapy system with Real-Time Tumor-Tracking has been developed, successfully installed and tested. The new system enables us to deliver higher dose to the moving target tumors while sparing surrounding normal tissues and to realize the compact design of the system and facility by maximizing the efficiency of proton beam utilization. This research is granted by the Japan Society for the Promotion of Science(JSPS) through the “Funding Program for World-Leading Innovative R and D on Science and Technology(FIRST Program)”, initiated by the Council for Science and Technology Policy(CSTP)},
doi = {10.1118/1.4887872},
url = {https://www.osti.gov/biblio/22333978}, journal = {Medical Physics},
issn = {0094-2405},
number = 6,
volume = 41,
place = {United States},
year = {Sun Jun 01 00:00:00 EDT 2014},
month = {Sun Jun 01 00:00:00 EDT 2014}
}