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Title: High resolution Cerenkov light imaging of induced positron distribution in proton therapy

Abstract

Purpose: In proton therapy, imaging of the positron distribution produced by fragmentation during or soon after proton irradiation is a useful method to monitor the proton range. Although positron emission tomography (PET) is typically used for this imaging, its spatial resolution is limited. Cerenkov light imaging is a new molecular imaging technology that detects the visible photons that are produced from high-speed electrons using a high sensitivity optical camera. Because its inherent spatial resolution is much higher than PET, the authors can measure more precise information of the proton-induced positron distribution with Cerenkov light imaging technology. For this purpose, they conducted Cerenkov light imaging of induced positron distribution in proton therapy. Methods: First, the authors evaluated the spatial resolution of our Cerenkov light imaging system with a {sup 22}Na point source for the actual imaging setup. Then the transparent acrylic phantoms (100 × 100 × 100 mm{sup 3}) were irradiated with two different proton energies using a spot scanning proton therapy system. Cerenkov light imaging of each phantom was conducted using a high sensitivity electron multiplied charge coupled device (EM-CCD) camera. Results: The Cerenkov light’s spatial resolution for the setup was 0.76 ± 0.6 mm FWHM. They obtained high resolutionmore » Cerenkov light images of the positron distributions in the phantoms for two different proton energies and made fused images of the reference images and the Cerenkov light images. The depths of the positron distribution in the phantoms from the Cerenkov light images were almost identical to the simulation results. The decay curves derived from the region-of-interests (ROIs) set on the Cerenkov light images revealed that Cerenkov light images can be used for estimating the half-life of the radionuclide components of positrons. Conclusions: High resolution Cerenkov light imaging of proton-induced positron distribution was possible. The authors conclude that Cerenkov light imaging of proton-induced positron is promising for proton therapy.« less

Authors:
; ; ; ;  [1];  [2]
  1. Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Aichi 461-8673 (Japan)
  2. Department of Proton Therapy Physics, Nagoya Proton Therapy Center, Nagoya City West Medical Center, Aichi 462-8508 (Japan)
Publication Date:
OSTI Identifier:
22320351
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 41; Journal Issue: 11; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 60 APPLIED LIFE SCIENCES; CHARGE-COUPLED DEVICES; DECAY; DIAGRAMS; DISTRIBUTION; ELECTRONS; HALF-LIFE; IRRADIATION; PHANTOMS; PHOTONS; POINT SOURCES; POSITRON COMPUTED TOMOGRAPHY; POSITRONS; PROTONS; SENSITIVITY; SIMULATION; SODIUM 22; SPATIAL RESOLUTION; THERAPY; VELOCITY

Citation Formats

Yamamoto, Seiichi, E-mail: s-yama@met.nagoya-u.ac.jp, Fujii, Kento, Morishita, Yuki, Okumura, Satoshi, Komori, Masataka, and Toshito, Toshiyuki. High resolution Cerenkov light imaging of induced positron distribution in proton therapy. United States: N. p., 2014. Web. doi:10.1118/1.4898592.
Yamamoto, Seiichi, E-mail: s-yama@met.nagoya-u.ac.jp, Fujii, Kento, Morishita, Yuki, Okumura, Satoshi, Komori, Masataka, & Toshito, Toshiyuki. High resolution Cerenkov light imaging of induced positron distribution in proton therapy. United States. doi:10.1118/1.4898592.
Yamamoto, Seiichi, E-mail: s-yama@met.nagoya-u.ac.jp, Fujii, Kento, Morishita, Yuki, Okumura, Satoshi, Komori, Masataka, and Toshito, Toshiyuki. Sat . "High resolution Cerenkov light imaging of induced positron distribution in proton therapy". United States. doi:10.1118/1.4898592.
@article{osti_22320351,
title = {High resolution Cerenkov light imaging of induced positron distribution in proton therapy},
author = {Yamamoto, Seiichi, E-mail: s-yama@met.nagoya-u.ac.jp and Fujii, Kento and Morishita, Yuki and Okumura, Satoshi and Komori, Masataka and Toshito, Toshiyuki},
abstractNote = {Purpose: In proton therapy, imaging of the positron distribution produced by fragmentation during or soon after proton irradiation is a useful method to monitor the proton range. Although positron emission tomography (PET) is typically used for this imaging, its spatial resolution is limited. Cerenkov light imaging is a new molecular imaging technology that detects the visible photons that are produced from high-speed electrons using a high sensitivity optical camera. Because its inherent spatial resolution is much higher than PET, the authors can measure more precise information of the proton-induced positron distribution with Cerenkov light imaging technology. For this purpose, they conducted Cerenkov light imaging of induced positron distribution in proton therapy. Methods: First, the authors evaluated the spatial resolution of our Cerenkov light imaging system with a {sup 22}Na point source for the actual imaging setup. Then the transparent acrylic phantoms (100 × 100 × 100 mm{sup 3}) were irradiated with two different proton energies using a spot scanning proton therapy system. Cerenkov light imaging of each phantom was conducted using a high sensitivity electron multiplied charge coupled device (EM-CCD) camera. Results: The Cerenkov light’s spatial resolution for the setup was 0.76 ± 0.6 mm FWHM. They obtained high resolution Cerenkov light images of the positron distributions in the phantoms for two different proton energies and made fused images of the reference images and the Cerenkov light images. The depths of the positron distribution in the phantoms from the Cerenkov light images were almost identical to the simulation results. The decay curves derived from the region-of-interests (ROIs) set on the Cerenkov light images revealed that Cerenkov light images can be used for estimating the half-life of the radionuclide components of positrons. Conclusions: High resolution Cerenkov light imaging of proton-induced positron distribution was possible. The authors conclude that Cerenkov light imaging of proton-induced positron is promising for proton therapy.},
doi = {10.1118/1.4898592},
journal = {Medical Physics},
issn = {0094-2405},
number = 11,
volume = 41,
place = {United States},
year = {2014},
month = {11}
}