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Title: Synthesis and characterisation of platinum (II) salphen complex and its interaction with calf thymus DNA

Abstract

A platinum (II) salphen complex was synthesised by condensation reaction of 2,4-dihydroxylbenzaldehyde and o-phenylenediamine with potassium tetrachloroplatinate to obtain N,N′-Bis-4-(hydroxysalicylidene)-phenylenediamine-platinum (II). The structure of the complex was confirmed by {sup 1}H and {sup 13}C NMR spectroscopy, FTIR spectroscopy, CHN elemental analyses and ESI-MS spectrometry. The platinum (II) salphen complex with four donor atoms N{sub 2}O{sub 2} from its salphen ligand coordinated to platinum (II) metal centre were determined. The binding mode and interaction of this complex with calf thymus DNA was determined by UV/Vis DNA titration and emission titration. The intercalation between the DNA bases by π-π stacking due to its square planar geometry and aromatic rings structures was proposed.

Authors:
; ;  [1]
  1. School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43650 Bangi, Selangor (Malaysia)
Publication Date:
OSTI Identifier:
22308337
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1614; Journal Issue: 1; Conference: 2014 UKM FST postgraduate colloquium, Selangor (Malaysia), 9-11 Apr 2014; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CARBON 13; DNA; FOURIER TRANSFORMATION; HYDROGEN 1; INFRARED SPECTRA; NITROUS OXIDE; NUCLEAR MAGNETIC RESONANCE; PLATINUM; SPECTROSCOPY; SYNTHESIS; THYMUS; TITRATION

Citation Formats

Sukri, Shahratul Ain Mohd, Heng, Lee Yook, and Karim, Nurul Huda Abd. Synthesis and characterisation of platinum (II) salphen complex and its interaction with calf thymus DNA. United States: N. p., 2014. Web. doi:10.1063/1.4895234.
Sukri, Shahratul Ain Mohd, Heng, Lee Yook, & Karim, Nurul Huda Abd. Synthesis and characterisation of platinum (II) salphen complex and its interaction with calf thymus DNA. United States. doi:10.1063/1.4895234.
Sukri, Shahratul Ain Mohd, Heng, Lee Yook, and Karim, Nurul Huda Abd. Wed . "Synthesis and characterisation of platinum (II) salphen complex and its interaction with calf thymus DNA". United States. doi:10.1063/1.4895234.
@article{osti_22308337,
title = {Synthesis and characterisation of platinum (II) salphen complex and its interaction with calf thymus DNA},
author = {Sukri, Shahratul Ain Mohd and Heng, Lee Yook and Karim, Nurul Huda Abd},
abstractNote = {A platinum (II) salphen complex was synthesised by condensation reaction of 2,4-dihydroxylbenzaldehyde and o-phenylenediamine with potassium tetrachloroplatinate to obtain N,N′-Bis-4-(hydroxysalicylidene)-phenylenediamine-platinum (II). The structure of the complex was confirmed by {sup 1}H and {sup 13}C NMR spectroscopy, FTIR spectroscopy, CHN elemental analyses and ESI-MS spectrometry. The platinum (II) salphen complex with four donor atoms N{sub 2}O{sub 2} from its salphen ligand coordinated to platinum (II) metal centre were determined. The binding mode and interaction of this complex with calf thymus DNA was determined by UV/Vis DNA titration and emission titration. The intercalation between the DNA bases by π-π stacking due to its square planar geometry and aromatic rings structures was proposed.},
doi = {10.1063/1.4895234},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1614,
place = {United States},
year = {Wed Sep 03 00:00:00 EDT 2014},
month = {Wed Sep 03 00:00:00 EDT 2014}
}