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Title: Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors

Abstract

We analyze the contributions of quality factor, fill fraction, and group index of chip-integrated resonance microcavity devices, to the detection limit for bulk chemical sensing and the minimum detectable biomolecule concentration in biosensing. We analyze the contributions from analyte absorbance, as well as from temperature and spectral noise. Slow light in two-dimensional photonic crystals provide opportunities for significant reduction of the detection limit below 1 × 10{sup −7} RIU (refractive index unit) which can enable highly sensitive sensors in diverse application areas. We demonstrate experimentally detected concentration of 1 fM (67 fg/ml) for the binding between biotin and avidin, the lowest reported till date.

Authors:
; ;  [1]; ;  [2];  [1];  [3]
  1. Omega Optics, Inc., Austin, Texas 78757 (United States)
  2. Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, Texas 78758 (United States)
  3. (United States)
Publication Date:
OSTI Identifier:
22273398
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 104; Journal Issue: 19; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; AVIDIN; BIOTIN; CONCENTRATION RATIO; CRYSTALS; QUALITY FACTOR; REFRACTIVE INDEX; SENSITIVITY; SENSORS

Citation Formats

Chakravarty, Swapnajit, E-mail: swapnajit.chakravarty@omegaoptics.com, Hosseini, Amir, Xu, Xiaochuan, Zhu, Liang, Zou, Yi, Chen, Ray T., E-mail: raychen@uts.cc.utexas.edu, and Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, Texas 78758. Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors. United States: N. p., 2014. Web. doi:10.1063/1.4875903.
Chakravarty, Swapnajit, E-mail: swapnajit.chakravarty@omegaoptics.com, Hosseini, Amir, Xu, Xiaochuan, Zhu, Liang, Zou, Yi, Chen, Ray T., E-mail: raychen@uts.cc.utexas.edu, & Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, Texas 78758. Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors. United States. doi:10.1063/1.4875903.
Chakravarty, Swapnajit, E-mail: swapnajit.chakravarty@omegaoptics.com, Hosseini, Amir, Xu, Xiaochuan, Zhu, Liang, Zou, Yi, Chen, Ray T., E-mail: raychen@uts.cc.utexas.edu, and Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, Texas 78758. 2014. "Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors". United States. doi:10.1063/1.4875903.
@article{osti_22273398,
title = {Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors},
author = {Chakravarty, Swapnajit, E-mail: swapnajit.chakravarty@omegaoptics.com and Hosseini, Amir and Xu, Xiaochuan and Zhu, Liang and Zou, Yi and Chen, Ray T., E-mail: raychen@uts.cc.utexas.edu and Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, Texas 78758},
abstractNote = {We analyze the contributions of quality factor, fill fraction, and group index of chip-integrated resonance microcavity devices, to the detection limit for bulk chemical sensing and the minimum detectable biomolecule concentration in biosensing. We analyze the contributions from analyte absorbance, as well as from temperature and spectral noise. Slow light in two-dimensional photonic crystals provide opportunities for significant reduction of the detection limit below 1 × 10{sup −7} RIU (refractive index unit) which can enable highly sensitive sensors in diverse application areas. We demonstrate experimentally detected concentration of 1 fM (67 fg/ml) for the binding between biotin and avidin, the lowest reported till date.},
doi = {10.1063/1.4875903},
journal = {Applied Physics Letters},
number = 19,
volume = 104,
place = {United States},
year = 2014,
month = 5
}
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  • Abstract not provided.