skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Risk of Leptomeningeal Disease in Patients Treated With Stereotactic Radiosurgery Targeting the Postoperative Resection Cavity for Brain Metastases

Abstract

Purpose: We sought to determine the risk of leptomeningeal disease (LMD) in patients treated with stereotactic radiosurgery (SRS) targeting the postsurgical resection cavity of a brain metastasis, deferring whole-brain radiation therapy (WBRT) in all patients. Methods and Materials: We retrospectively reviewed 175 brain metastasis resection cavities in 165 patients treated from 1998 to 2011 with postoperative SRS. The cumulative incidence rates, with death as a competing risk, of LMD, local failure (LF), and distant brain parenchymal failure (DF) were estimated. Variables associated with LMD were evaluated, including LF, DF, posterior fossa location, resection type (en-bloc vs piecemeal or unknown), and histology (lung, colon, breast, melanoma, gynecologic, other). Results: With a median follow-up of 12 months (range, 1-157 months), median overall survival was 17 months. Twenty-one of 165 patients (13%) developed LMD at a median of 5 months (range, 2-33 months) following SRS. The 1-year cumulative incidence rates, with death as a competing risk, were 10% (95% confidence interval [CI], 6%-15%) for developing LF, 54% (95% CI, 46%-61%) for DF, and 11% (95% CI, 7%-17%) for LMD. On univariate analysis, only breast cancer histology (hazard ratio, 2.96) was associated with an increased risk of LMD. The 1-year cumulative incidence of LMDmore » was 24% (95% CI, 9%-41%) for breast cancer compared to 9% (95% CI, 5%-14%) for non-breast histology (P=.004). Conclusions: In patients treated with SRS targeting the postoperative cavity following resection, those with breast cancer histology were at higher risk of LMD. It is unknown whether the inclusion of whole-brain irradiation or novel strategies such as preresection SRS would improve this risk or if the rate of LMD is inherently higher with breast histology.« less

Authors:
 [1];  [2]; ;  [3];  [2]; ; ;  [3];  [4];  [2]
  1. Department of Radiation Oncology, Acibadem University School of Medicine, Istanbul (Turkey)
  2. Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States)
  3. Department of Neurosurgery, Stanford University Medical Center, Stanford, California (United States)
  4. Department of Neurology, Stanford University Medical Center, Stanford, California (United States)
Publication Date:
OSTI Identifier:
22267940
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 87; Journal Issue: 4; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; MELANOMAS; METASTASES; RADIOTHERAPY; SIDE EFFECTS; SURGERY

Citation Formats

Atalar, Banu, Modlin, Leslie A., Choi, Clara Y.H., Adler, John R., Gibbs, Iris C., Chang, Steven D., Harsh, Griffith R., Li, Gordon, Nagpal, Seema, Hanlon, Alexandra, and Soltys, Scott G., E-mail: sgsoltys@stanford.edu. Risk of Leptomeningeal Disease in Patients Treated With Stereotactic Radiosurgery Targeting the Postoperative Resection Cavity for Brain Metastases. United States: N. p., 2013. Web. doi:10.1016/J.IJROBP.2013.07.034.
Atalar, Banu, Modlin, Leslie A., Choi, Clara Y.H., Adler, John R., Gibbs, Iris C., Chang, Steven D., Harsh, Griffith R., Li, Gordon, Nagpal, Seema, Hanlon, Alexandra, & Soltys, Scott G., E-mail: sgsoltys@stanford.edu. Risk of Leptomeningeal Disease in Patients Treated With Stereotactic Radiosurgery Targeting the Postoperative Resection Cavity for Brain Metastases. United States. https://doi.org/10.1016/J.IJROBP.2013.07.034
Atalar, Banu, Modlin, Leslie A., Choi, Clara Y.H., Adler, John R., Gibbs, Iris C., Chang, Steven D., Harsh, Griffith R., Li, Gordon, Nagpal, Seema, Hanlon, Alexandra, and Soltys, Scott G., E-mail: sgsoltys@stanford.edu. 2013. "Risk of Leptomeningeal Disease in Patients Treated With Stereotactic Radiosurgery Targeting the Postoperative Resection Cavity for Brain Metastases". United States. https://doi.org/10.1016/J.IJROBP.2013.07.034.
@article{osti_22267940,
title = {Risk of Leptomeningeal Disease in Patients Treated With Stereotactic Radiosurgery Targeting the Postoperative Resection Cavity for Brain Metastases},
author = {Atalar, Banu and Modlin, Leslie A. and Choi, Clara Y.H. and Adler, John R. and Gibbs, Iris C. and Chang, Steven D. and Harsh, Griffith R. and Li, Gordon and Nagpal, Seema and Hanlon, Alexandra and Soltys, Scott G., E-mail: sgsoltys@stanford.edu},
abstractNote = {Purpose: We sought to determine the risk of leptomeningeal disease (LMD) in patients treated with stereotactic radiosurgery (SRS) targeting the postsurgical resection cavity of a brain metastasis, deferring whole-brain radiation therapy (WBRT) in all patients. Methods and Materials: We retrospectively reviewed 175 brain metastasis resection cavities in 165 patients treated from 1998 to 2011 with postoperative SRS. The cumulative incidence rates, with death as a competing risk, of LMD, local failure (LF), and distant brain parenchymal failure (DF) were estimated. Variables associated with LMD were evaluated, including LF, DF, posterior fossa location, resection type (en-bloc vs piecemeal or unknown), and histology (lung, colon, breast, melanoma, gynecologic, other). Results: With a median follow-up of 12 months (range, 1-157 months), median overall survival was 17 months. Twenty-one of 165 patients (13%) developed LMD at a median of 5 months (range, 2-33 months) following SRS. The 1-year cumulative incidence rates, with death as a competing risk, were 10% (95% confidence interval [CI], 6%-15%) for developing LF, 54% (95% CI, 46%-61%) for DF, and 11% (95% CI, 7%-17%) for LMD. On univariate analysis, only breast cancer histology (hazard ratio, 2.96) was associated with an increased risk of LMD. The 1-year cumulative incidence of LMD was 24% (95% CI, 9%-41%) for breast cancer compared to 9% (95% CI, 5%-14%) for non-breast histology (P=.004). Conclusions: In patients treated with SRS targeting the postoperative cavity following resection, those with breast cancer histology were at higher risk of LMD. It is unknown whether the inclusion of whole-brain irradiation or novel strategies such as preresection SRS would improve this risk or if the rate of LMD is inherently higher with breast histology.},
doi = {10.1016/J.IJROBP.2013.07.034},
url = {https://www.osti.gov/biblio/22267940}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 87,
place = {United States},
year = {Fri Nov 15 00:00:00 EST 2013},
month = {Fri Nov 15 00:00:00 EST 2013}
}