Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?

Matney, Jason; Park, Peter C.; Bluett, Jaques; Chen, Yi Pei; Liu, Wei; Court, Laurence E.; Liao, Zhongxing; Li, Heng; Mohan, Radhe

doi:10.1016/J.IJROBP.2013.07.007

Title: Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?

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Abstract

Purpose: To quantify and compare the effects of respiratory motion on paired passively scattered proton therapy (PSPT) and intensity modulated photon therapy (IMRT) plans; and to establish the relationship between the magnitude of tumor motion and the respiratory-induced dose difference for both modalities. Methods and Materials: In a randomized clinical trial comparing PSPT and IMRT, radiation therapy plans have been designed according to common planning protocols. Four-dimensional (4D) dose was computed for PSPT and IMRT plans for a patient cohort with respiratory motion ranging from 3 to 17 mm. Image registration and dose accumulation were performed using grayscale-based deformable image registration algorithms. The dose–volume histogram (DVH) differences (4D-3D [3D = 3-dimensional]) were compared for PSPT and IMRT. Changes in 4D-3D dose were correlated to the magnitude of tumor respiratory motion. Results: The average 4D-3D dose to 95% of the internal target volume was close to zero, with 19 of 20 patients within 1% of prescribed dose for both modalities. The mean 4D-3D between the 2 modalities was not statistically significant (P<.05) for all dose–volume histogram indices (mean ± SD) except the lung V5 (PSPT: +1.1% ± 0.9%; IMRT: +0.4% ± 1.2%) and maximum cord dose (PSPT: +1.5 ± 2.9 Gy;more »« less

Authors:

Matney, Jason; Park, Peter C. ^[1]; Bluett, Jaques ^[2]; Chen, Yi Pei ^[1]; Liu, Wei; Court, Laurence E. ^[1]; Liao, Zhongxing ^[2]; Li, Heng ^[1]; Mohan, Radhe ^[1]

Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

Publication Date:: Fri Nov 01 00:00:00 EDT 2013

OSTI Identifier:: 22267922

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 87; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; COMPARATIVE EVALUATIONS; LUNGS; NEOPLASMS; PATIENTS; PROTONS; RADIOTHERAPY; RESPIRATION

Citation Formats


                    Matney, Jason, Park, Peter C., The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, Bluett, Jaques, Chen, Yi Pei, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, Liu, Wei, Court, Laurence E., Liao, Zhongxing, Li, Heng, and Mohan, Radhe. Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?.  United States: N. p., 2013. 
        Web.  doi:10.1016/J.IJROBP.2013.07.007.

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                    Matney, Jason, Park, Peter C., The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, Bluett, Jaques, Chen, Yi Pei, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, Liu, Wei, Court, Laurence E., Liao, Zhongxing, Li, Heng, & Mohan, Radhe. Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?.  United States.  https://doi.org/10.1016/J.IJROBP.2013.07.007

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                    Matney, Jason, Park, Peter C., The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, Bluett, Jaques, Chen, Yi Pei, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, Liu, Wei, Court, Laurence E., Liao, Zhongxing, Li, Heng, and Mohan, Radhe. 2013.  
        "Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?".  United States.  https://doi.org/10.1016/J.IJROBP.2013.07.007.

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@article{osti_22267922,

  title        = {Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?},

  author       = {Matney, Jason and Park, Peter C. and The University of Texas Graduate School of Biomedical Sciences, Houston, Texas and Bluett, Jaques and Chen, Yi Pei and The University of Texas Graduate School of Biomedical Sciences, Houston, Texas and Liu, Wei and Court, Laurence E. and Liao, Zhongxing and Li, Heng and Mohan, Radhe},

  abstractNote = {Purpose: To quantify and compare the effects of respiratory motion on paired passively scattered proton therapy (PSPT) and intensity modulated photon therapy (IMRT) plans; and to establish the relationship between the magnitude of tumor motion and the respiratory-induced dose difference for both modalities. Methods and Materials: In a randomized clinical trial comparing PSPT and IMRT, radiation therapy plans have been designed according to common planning protocols. Four-dimensional (4D) dose was computed for PSPT and IMRT plans for a patient cohort with respiratory motion ranging from 3 to 17 mm. Image registration and dose accumulation were performed using grayscale-based deformable image registration algorithms. The dose–volume histogram (DVH) differences (4D-3D [3D = 3-dimensional]) were compared for PSPT and IMRT. Changes in 4D-3D dose were correlated to the magnitude of tumor respiratory motion. Results: The average 4D-3D dose to 95% of the internal target volume was close to zero, with 19 of 20 patients within 1% of prescribed dose for both modalities. The mean 4D-3D between the 2 modalities was not statistically significant (P<.05) for all dose–volume histogram indices (mean ± SD) except the lung V5 (PSPT: +1.1% ± 0.9%; IMRT: +0.4% ± 1.2%) and maximum cord dose (PSPT: +1.5 ± 2.9 Gy; IMRT: 0.0 ± 0.2 Gy). Changes in 4D-3D dose were correlated to tumor motion for only 2 indices: dose to 95% planning target volume, and heterogeneity index. Conclusions: With our current margin formalisms, target coverage was maintained in the presence of respiratory motion up to 17 mm for both PSPT and IMRT. Only 2 of 11 4D-3D indices (lung V5 and spinal cord maximum) were statistically distinguishable between PSPT and IMRT, contrary to the notion that proton therapy will be more susceptible to respiratory motion. Because of the lack of strong correlations with 4D-3D dose differences in PSPT and IMRT, the extent of tumor motion was not an adequate predictor of potential dosimetric error caused by breathing motion.},

  doi          = {10.1016/J.IJROBP.2013.07.007},

  url          = {https://www.osti.gov/biblio/22267922},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 3,

  volume       = 87,

  place        = {United States},

  year         = {Fri Nov 01 00:00:00 EDT 2013},

  month        = {Fri Nov 01 00:00:00 EDT 2013}

}

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