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Title: Developing high-frequency ultrasound tomography for testicular tumor imaging in rats: An in vitro study

Abstract

Purpose: This paper describes a feasibility study for developing a 35-MHz high-frequency ultrasound computed-tomography (HFUCT) system for imaging rat testicles. Methods: The performances of two kinds of HFUCT-attenuation and sound-speed UCT-based on transmission and pulse-echo modes were investigated in this study. Experiments were carried out using phantoms and actual rat testiclesin vitro. HFUCT images were reconstructed using a filtered backprojection algorithm. Results: The phantom experimental results indicated that all types of HFUCT can determine the dimensions of a plastic cylinder with a diameter of 500μm. Compared to sound-speed HFUCT, attenuation HFUCT exhibited a better performance in recognizing a tiny sclerosed region in a gelatin phantom. Therefore, the in vitro testicular experiments were performed using attenuation HFUCT based on transmission and pulse-echo modes. The experimentally measured attenuation coefficient and sound speed for healthy rat testicles were 2.92 ± 0.25 dB/mm and 1537 ± 25 m/s, respectively. Conclusions: A homogeneous texture was evident for healthy testicles using both modes. An artificial sclerosed tumor could also be clearly observed using two- and three-dimensional attenuation HFUCT in both modes. However, an object artifact was apparent in pulse-echo mode because of ultrasound beam refraction. All of the obtained experimental results indicate the potential of usingmore » HFUCT as a novel tool for monitoring the preclinical responses of testicular tumors in small animals.« less

Authors:
 [1];  [2]
  1. Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan (China)
  2. Department of Electrical Engineering, Fu Jen Catholic University, New Taipei City 24205, Taiwan (China)
Publication Date:
OSTI Identifier:
22250723
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 41; Journal Issue: 1; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALGORITHMS; ATTENUATION; COMPUTERIZED TOMOGRAPHY; GELATIN; IN VITRO; NEOPLASMS; PHANTOMS; RATS; TESTES

Citation Formats

Huang, Chih-Chung, E-mail: cchuang@mail.ncku.edu.tw, and Chen, Wei-Tsen. Developing high-frequency ultrasound tomography for testicular tumor imaging in rats: An in vitro study. United States: N. p., 2014. Web. doi:10.1118/1.4852915.
Huang, Chih-Chung, E-mail: cchuang@mail.ncku.edu.tw, & Chen, Wei-Tsen. Developing high-frequency ultrasound tomography for testicular tumor imaging in rats: An in vitro study. United States. doi:10.1118/1.4852915.
Huang, Chih-Chung, E-mail: cchuang@mail.ncku.edu.tw, and Chen, Wei-Tsen. Wed . "Developing high-frequency ultrasound tomography for testicular tumor imaging in rats: An in vitro study". United States. doi:10.1118/1.4852915.
@article{osti_22250723,
title = {Developing high-frequency ultrasound tomography for testicular tumor imaging in rats: An in vitro study},
author = {Huang, Chih-Chung, E-mail: cchuang@mail.ncku.edu.tw and Chen, Wei-Tsen},
abstractNote = {Purpose: This paper describes a feasibility study for developing a 35-MHz high-frequency ultrasound computed-tomography (HFUCT) system for imaging rat testicles. Methods: The performances of two kinds of HFUCT-attenuation and sound-speed UCT-based on transmission and pulse-echo modes were investigated in this study. Experiments were carried out using phantoms and actual rat testiclesin vitro. HFUCT images were reconstructed using a filtered backprojection algorithm. Results: The phantom experimental results indicated that all types of HFUCT can determine the dimensions of a plastic cylinder with a diameter of 500μm. Compared to sound-speed HFUCT, attenuation HFUCT exhibited a better performance in recognizing a tiny sclerosed region in a gelatin phantom. Therefore, the in vitro testicular experiments were performed using attenuation HFUCT based on transmission and pulse-echo modes. The experimentally measured attenuation coefficient and sound speed for healthy rat testicles were 2.92 ± 0.25 dB/mm and 1537 ± 25 m/s, respectively. Conclusions: A homogeneous texture was evident for healthy testicles using both modes. An artificial sclerosed tumor could also be clearly observed using two- and three-dimensional attenuation HFUCT in both modes. However, an object artifact was apparent in pulse-echo mode because of ultrasound beam refraction. All of the obtained experimental results indicate the potential of using HFUCT as a novel tool for monitoring the preclinical responses of testicular tumors in small animals.},
doi = {10.1118/1.4852915},
journal = {Medical Physics},
number = 1,
volume = 41,
place = {United States},
year = {Wed Jan 15 00:00:00 EST 2014},
month = {Wed Jan 15 00:00:00 EST 2014}
}