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Title: Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation Therapy for Early-Stage Cervical Cancer

Abstract

Purpose: The purpose of this study was to evaluate dose-volume histogram (DVH) predictors for the development of chronic gastrointestinal (GI) complications in cervical cancer patients who underwent radical hysterectomy and postoperative concurrent nedaplatin-based chemoradiation therapy. Methods and Materials: This study analyzed 97 patients who underwent postoperative concurrent chemoradiation therapy. The organs at risk that were contoured were the small bowel loops, large bowel loop, and peritoneal cavity. DVH parameters subjected to analysis included the volumes of these organs receiving more than 15, 30, 40, and 45 Gy (V15-V45) and their mean dose. Associations between DVH parameters or clinical factors and the incidence of grade 2 or higher chronic GI complications were evaluated. Results: Of the clinical factors, smoking and low body mass index (BMI) (<22) were significantly associated with grade 2 or higher chronic GI complications. Also, patients with chronic GI complications had significantly greater V15-V45 volumes and higher mean dose of the small bowel loops compared with those without GI complications. In contrast, no parameters for the large bowel loop or peritoneal cavity were significantly associated with GI complications. Results of the receiver operating characteristics (ROC) curve analysis led to the conclusion that V15-V45 of the small bowel loopsmore » has high accuracy for prediction of GI complications. Among these parameters, V40 gave the highest area under the ROC curve. Finally, multivariate analysis was performed with V40 of the small bowel loops and 2 other clinical parameters that were judged to be potential risk factors for chronic GI complications: BMI and smoking. Of these 3 parameters, V40 of the small bowel loops and smoking emerged as independent predictors of chronic GI complications. Conclusions: DVH parameters of the small bowel loops may serve as predictors of grade 2 or higher chronic GI complications after postoperative concurrent nedaplatin-based chemoradiation therapy for early-stage cervical cancer.« less

Authors:
 [1];  [1];  [2];  [1]; ; ;  [1];  [3];  [1];  [2];  [1]
  1. Department of Radiation Oncology, Osaka University Hospital, Suita, Osaka (Japan)
  2. Department of Obstetrics and Gynecology, Osaka University Hospital, Suita, Osaka (Japan)
  3. (Japan)
Publication Date:
OSTI Identifier:
22224372
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 85; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; HEALTH HAZARDS; MULTIVARIATE ANALYSIS; NEOPLASMS; ORGANS; PATIENTS; SMOKES

Citation Formats

Isohashi, Fumiaki, E-mail: isohashi@radonc.med.osaka-u.ac.jp, Yoshioka, Yasuo, Mabuchi, Seiji, Konishi, Koji, Koizumi, Masahiko, Takahashi, Yutaka, Ogata, Toshiyuki, Division of Medical Physics, Oncology Center, Osaka University Hospital, Suita, Osaka, Maruoka, Shintaroh, Kimura, Tadashi, and Ogawa, Kazuhiko. Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation Therapy for Early-Stage Cervical Cancer. United States: N. p., 2013. Web. doi:10.1016/J.IJROBP.2012.05.021.
Isohashi, Fumiaki, E-mail: isohashi@radonc.med.osaka-u.ac.jp, Yoshioka, Yasuo, Mabuchi, Seiji, Konishi, Koji, Koizumi, Masahiko, Takahashi, Yutaka, Ogata, Toshiyuki, Division of Medical Physics, Oncology Center, Osaka University Hospital, Suita, Osaka, Maruoka, Shintaroh, Kimura, Tadashi, & Ogawa, Kazuhiko. Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation Therapy for Early-Stage Cervical Cancer. United States. doi:10.1016/J.IJROBP.2012.05.021.
Isohashi, Fumiaki, E-mail: isohashi@radonc.med.osaka-u.ac.jp, Yoshioka, Yasuo, Mabuchi, Seiji, Konishi, Koji, Koizumi, Masahiko, Takahashi, Yutaka, Ogata, Toshiyuki, Division of Medical Physics, Oncology Center, Osaka University Hospital, Suita, Osaka, Maruoka, Shintaroh, Kimura, Tadashi, and Ogawa, Kazuhiko. Fri . "Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation Therapy for Early-Stage Cervical Cancer". United States. doi:10.1016/J.IJROBP.2012.05.021.
@article{osti_22224372,
title = {Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation Therapy for Early-Stage Cervical Cancer},
author = {Isohashi, Fumiaki, E-mail: isohashi@radonc.med.osaka-u.ac.jp and Yoshioka, Yasuo and Mabuchi, Seiji and Konishi, Koji and Koizumi, Masahiko and Takahashi, Yutaka and Ogata, Toshiyuki and Division of Medical Physics, Oncology Center, Osaka University Hospital, Suita, Osaka and Maruoka, Shintaroh and Kimura, Tadashi and Ogawa, Kazuhiko},
abstractNote = {Purpose: The purpose of this study was to evaluate dose-volume histogram (DVH) predictors for the development of chronic gastrointestinal (GI) complications in cervical cancer patients who underwent radical hysterectomy and postoperative concurrent nedaplatin-based chemoradiation therapy. Methods and Materials: This study analyzed 97 patients who underwent postoperative concurrent chemoradiation therapy. The organs at risk that were contoured were the small bowel loops, large bowel loop, and peritoneal cavity. DVH parameters subjected to analysis included the volumes of these organs receiving more than 15, 30, 40, and 45 Gy (V15-V45) and their mean dose. Associations between DVH parameters or clinical factors and the incidence of grade 2 or higher chronic GI complications were evaluated. Results: Of the clinical factors, smoking and low body mass index (BMI) (<22) were significantly associated with grade 2 or higher chronic GI complications. Also, patients with chronic GI complications had significantly greater V15-V45 volumes and higher mean dose of the small bowel loops compared with those without GI complications. In contrast, no parameters for the large bowel loop or peritoneal cavity were significantly associated with GI complications. Results of the receiver operating characteristics (ROC) curve analysis led to the conclusion that V15-V45 of the small bowel loops has high accuracy for prediction of GI complications. Among these parameters, V40 gave the highest area under the ROC curve. Finally, multivariate analysis was performed with V40 of the small bowel loops and 2 other clinical parameters that were judged to be potential risk factors for chronic GI complications: BMI and smoking. Of these 3 parameters, V40 of the small bowel loops and smoking emerged as independent predictors of chronic GI complications. Conclusions: DVH parameters of the small bowel loops may serve as predictors of grade 2 or higher chronic GI complications after postoperative concurrent nedaplatin-based chemoradiation therapy for early-stage cervical cancer.},
doi = {10.1016/J.IJROBP.2012.05.021},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 85,
place = {United States},
year = {2013},
month = {3}
}