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Title: A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion

Abstract

Caffeine is a definite factor of intrauterine growth retardation (IUGR). Previously, we have confirmed that prenatal caffeine ingestion inhibits the development of hypothalamic–pituitary–adrenal (HPA) axis, and alters the glucose and lipid metabolism in IUGR fetal rats. In this study, we aimed to verify a programmed alteration of neuroendocrine metabolism in prenatal caffeine ingested-offspring rats. The results showed that prenatal caffeine (120 mg/kg.day) ingestion caused low body weight and high IUGR rate of pups; the concentrations of blood adrenocorticotropic hormone (ACTH) and corticosterone in caffeine group were significantly increased in the early postnatal period followed by falling in late stage; the level of blood glucose was unchanged, while blood total cholesterol (TCH) and triglyceride (TG) were markedly enhanced in adult. After chronic stress, the concentrations and the gain rates of blood ACTH and corticosterone were obviously increased, meanwhile, the blood glucose increased while the TCH and TG decreased in caffeine group. Further, the hippocampal mineralocorticoid receptor (MR) expression in caffeine group was initially decreased and subsequently increased after birth. After chronic stress, the 11β-hydroxysteroid dehydrogenase-1, glucocorticoid receptor (GR), MR as well as the MR/GR ratio were all significantly decreased. These results suggested that prenatal caffeine ingestion induced the dysfunction of HPAmore » axis and associated neuroendocrine metabolic programmed alteration in IUGR offspring rats, which might be related with the functional injury of hippocampus. These observations provide a valuable experimental basis for explaining the susceptibility of IUGR offspring to metabolic syndrome and associated diseases. -- Highlights: ► Prenatal caffeine ingestion induced HPA axis dysfunction in IUGR offspring rats. ► Caffeine induced a neuroendocrine metabolic programmed alteration in offspring rats. ► Caffeine induced a functional injury of hippocampus in IUGR offspring rats.« less

Authors:
 [1];  [2]; ; ; ; ; ;  [1];  [1];  [2];  [3];  [1];  [3];  [4];  [1];  [2]
  1. Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071 (China)
  2. (China)
  3. Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China)
  4. UMR 7561 CNRS-Nancy Université, Faculté de Médicine, Vandoeuvre-lès-Nancy (France)
Publication Date:
OSTI Identifier:
22215960
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 264; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ACTH; BLOOD; CAFFEINE; CHOLESTEROL; CORTICOSTERONE; GLUCOSE; HIPPOCAMPUS; INGESTION; INJURIES; METABOLISM; RATS; RECEPTORS; TRIGLYCERIDES

Citation Formats

Xu, D., Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, Wu, Y., Liu, F., Liu, Y.S., Shen, L., Lei, Y.Y., Liu, J., Ping, J., Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, Qin, J., Zhang, C., Chen, L.B., Magdalou, J., Wang, H., E-mail: wanghui19@whu.edu.cn, and Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071. A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion. United States: N. p., 2012. Web. doi:10.1016/J.TAAP.2012.08.016.
Xu, D., Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, Wu, Y., Liu, F., Liu, Y.S., Shen, L., Lei, Y.Y., Liu, J., Ping, J., Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, Qin, J., Zhang, C., Chen, L.B., Magdalou, J., Wang, H., E-mail: wanghui19@whu.edu.cn, & Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071. A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion. United States. doi:10.1016/J.TAAP.2012.08.016.
Xu, D., Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, Wu, Y., Liu, F., Liu, Y.S., Shen, L., Lei, Y.Y., Liu, J., Ping, J., Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, Qin, J., Zhang, C., Chen, L.B., Magdalou, J., Wang, H., E-mail: wanghui19@whu.edu.cn, and Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071. Thu . "A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion". United States. doi:10.1016/J.TAAP.2012.08.016.
@article{osti_22215960,
title = {A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion},
author = {Xu, D. and Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071 and Wu, Y. and Liu, F. and Liu, Y.S. and Shen, L. and Lei, Y.Y. and Liu, J. and Ping, J. and Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071 and Qin, J. and Zhang, C. and Chen, L.B. and Magdalou, J. and Wang, H., E-mail: wanghui19@whu.edu.cn and Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071},
abstractNote = {Caffeine is a definite factor of intrauterine growth retardation (IUGR). Previously, we have confirmed that prenatal caffeine ingestion inhibits the development of hypothalamic–pituitary–adrenal (HPA) axis, and alters the glucose and lipid metabolism in IUGR fetal rats. In this study, we aimed to verify a programmed alteration of neuroendocrine metabolism in prenatal caffeine ingested-offspring rats. The results showed that prenatal caffeine (120 mg/kg.day) ingestion caused low body weight and high IUGR rate of pups; the concentrations of blood adrenocorticotropic hormone (ACTH) and corticosterone in caffeine group were significantly increased in the early postnatal period followed by falling in late stage; the level of blood glucose was unchanged, while blood total cholesterol (TCH) and triglyceride (TG) were markedly enhanced in adult. After chronic stress, the concentrations and the gain rates of blood ACTH and corticosterone were obviously increased, meanwhile, the blood glucose increased while the TCH and TG decreased in caffeine group. Further, the hippocampal mineralocorticoid receptor (MR) expression in caffeine group was initially decreased and subsequently increased after birth. After chronic stress, the 11β-hydroxysteroid dehydrogenase-1, glucocorticoid receptor (GR), MR as well as the MR/GR ratio were all significantly decreased. These results suggested that prenatal caffeine ingestion induced the dysfunction of HPA axis and associated neuroendocrine metabolic programmed alteration in IUGR offspring rats, which might be related with the functional injury of hippocampus. These observations provide a valuable experimental basis for explaining the susceptibility of IUGR offspring to metabolic syndrome and associated diseases. -- Highlights: ► Prenatal caffeine ingestion induced HPA axis dysfunction in IUGR offspring rats. ► Caffeine induced a neuroendocrine metabolic programmed alteration in offspring rats. ► Caffeine induced a functional injury of hippocampus in IUGR offspring rats.},
doi = {10.1016/J.TAAP.2012.08.016},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 3,
volume = 264,
place = {United States},
year = {2012},
month = {11}
}