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Title: Photodynamic action of curcumin derived polymer modified ZnO nanocomposites

Abstract

Highlights: ► ZnO/PVA nano sensitized with curcumin and its metal complex were synthesized by vacuum evaporation method. ► M/cur sensitized on ZnO/PVA nanocomposites were characterized. ► Generation of {sup 1}O{sub 2} and ROS were detected by optical and EPR-spin trapping method. ► It was found that photoinduced cleavage of DNA using Zn/cur–ZnO/PVA was superior. ► Photodegradation of MB in water catalyzed by ZnO/PVA–Zn/cur was also superior under visible light. -- Abstract: The photodynamic action of ZnO nano can be improved by modifying the surface by PVA and encapsulating the natural product, curcumin. The synthesized ZnO/PVA nanocomposites have been characterized using XRD, SEM, TEM, FTIR, TG–DTA, etc. Here we are reporting the photodynamic effect of ZnO nanocomposites on pUC18 DNA. Based on optical and EPR measurements, singlet oxygen and other ROS were responsible for photocleavage of DNA. Most importantly, derived curcumin modified ZnO/PVA nanocomposites were comparatively more effective than derived curcumin complex against HeLa cell lines under in vitro condition. In addition, photodegradation of methylene blue (MB) in water catalyzed by nano ZnO/PVA–curcumin derivative was investigated at room temperature. Under visible irradiation photocatalytic activity of ZnO nanomaterial sensitized curcumin was higher than those of curcumin and nano ZnO.

Authors:
;  [1];  [2];  [1]
  1. P.G. Department of Chemistry, Cardamom Planters’ Association College, Bodinayakanur 625513, Tamil Nadu (India)
  2. P.G. and Research Department of Chemistry, Thiagarajar College, Madurai 625009, Tamil Nadu (India)
Publication Date:
OSTI Identifier:
22215541
Resource Type:
Journal Article
Journal Name:
Materials Research Bulletin
Additional Journal Information:
Journal Volume: 47; Journal Issue: 11; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0025-5408
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY; COMPOSITE MATERIALS; CURCUMIN; ELECTRON SPIN RESONANCE; FOURIER TRANSFORMATION; HELA CELLS; IN VITRO; INFRARED SPECTRA; METHYLENE BLUE; NANOSTRUCTURES; PVA; SCANNING ELECTRON MICROSCOPY; SEMICONDUCTOR MATERIALS; THERMAL GRAVIMETRIC ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; VACUUM EVAPORATION; X-RAY DIFFRACTION; ZINC OXIDES

Citation Formats

Hariharan, R., Senthilkumar, S., Suganthi, A., E-mail: suganthiphd09@gmail.com, and Rajarajan, M., E-mail: rajarajan_1962@yahoo.com. Photodynamic action of curcumin derived polymer modified ZnO nanocomposites. United States: N. p., 2012. Web. doi:10.1016/J.MATERRESBULL.2012.08.028.
Hariharan, R., Senthilkumar, S., Suganthi, A., E-mail: suganthiphd09@gmail.com, & Rajarajan, M., E-mail: rajarajan_1962@yahoo.com. Photodynamic action of curcumin derived polymer modified ZnO nanocomposites. United States. doi:10.1016/J.MATERRESBULL.2012.08.028.
Hariharan, R., Senthilkumar, S., Suganthi, A., E-mail: suganthiphd09@gmail.com, and Rajarajan, M., E-mail: rajarajan_1962@yahoo.com. Thu . "Photodynamic action of curcumin derived polymer modified ZnO nanocomposites". United States. doi:10.1016/J.MATERRESBULL.2012.08.028.
@article{osti_22215541,
title = {Photodynamic action of curcumin derived polymer modified ZnO nanocomposites},
author = {Hariharan, R. and Senthilkumar, S. and Suganthi, A., E-mail: suganthiphd09@gmail.com and Rajarajan, M., E-mail: rajarajan_1962@yahoo.com},
abstractNote = {Highlights: ► ZnO/PVA nano sensitized with curcumin and its metal complex were synthesized by vacuum evaporation method. ► M/cur sensitized on ZnO/PVA nanocomposites were characterized. ► Generation of {sup 1}O{sub 2} and ROS were detected by optical and EPR-spin trapping method. ► It was found that photoinduced cleavage of DNA using Zn/cur–ZnO/PVA was superior. ► Photodegradation of MB in water catalyzed by ZnO/PVA–Zn/cur was also superior under visible light. -- Abstract: The photodynamic action of ZnO nano can be improved by modifying the surface by PVA and encapsulating the natural product, curcumin. The synthesized ZnO/PVA nanocomposites have been characterized using XRD, SEM, TEM, FTIR, TG–DTA, etc. Here we are reporting the photodynamic effect of ZnO nanocomposites on pUC18 DNA. Based on optical and EPR measurements, singlet oxygen and other ROS were responsible for photocleavage of DNA. Most importantly, derived curcumin modified ZnO/PVA nanocomposites were comparatively more effective than derived curcumin complex against HeLa cell lines under in vitro condition. In addition, photodegradation of methylene blue (MB) in water catalyzed by nano ZnO/PVA–curcumin derivative was investigated at room temperature. Under visible irradiation photocatalytic activity of ZnO nanomaterial sensitized curcumin was higher than those of curcumin and nano ZnO.},
doi = {10.1016/J.MATERRESBULL.2012.08.028},
journal = {Materials Research Bulletin},
issn = {0025-5408},
number = 11,
volume = 47,
place = {United States},
year = {2012},
month = {11}
}