Photodynamic action of curcumin derived polymer modified ZnO nanocomposites

Journal Article · Thu Nov 15 00:00:00 EST 2012 · Materials Research Bulletin

DOI:https://doi.org/10.1016/J.MATERRESBULL.2012.08.028· OSTI ID:22215541

Hariharan, R.; Senthilkumar, S. ^[1]

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1. P.G. Department of Chemistry, Cardamom Planters’ Association College, Bodinayakanur 625513, Tamil Nadu (India)

Highlights: ► ZnO/PVA nano sensitized with curcumin and its metal complex were synthesized by vacuum evaporation method. ► M/cur sensitized on ZnO/PVA nanocomposites were characterized. ► Generation of {sup 1}O{sub 2} and ROS were detected by optical and EPR-spin trapping method. ► It was found that photoinduced cleavage of DNA using Zn/cur–ZnO/PVA was superior. ► Photodegradation of MB in water catalyzed by ZnO/PVA–Zn/cur was also superior under visible light. -- Abstract: The photodynamic action of ZnO nano can be improved by modifying the surface by PVA and encapsulating the natural product, curcumin. The synthesized ZnO/PVA nanocomposites have been characterized using XRD, SEM, TEM, FTIR, TG–DTA, etc. Here we are reporting the photodynamic effect of ZnO nanocomposites on pUC18 DNA. Based on optical and EPR measurements, singlet oxygen and other ROS were responsible for photocleavage of DNA. Most importantly, derived curcumin modified ZnO/PVA nanocomposites were comparatively more effective than derived curcumin complex against HeLa cell lines under in vitro condition. In addition, photodegradation of methylene blue (MB) in water catalyzed by nano ZnO/PVA–curcumin derivative was investigated at room temperature. Under visible irradiation photocatalytic activity of ZnO nanomaterial sensitized curcumin was higher than those of curcumin and nano ZnO.

• OSTI ID: 22215541
• Journal Information: Materials Research Bulletin, Vol. 47, Issue 11; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0025-5408
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
77 NANOSCIENCE AND NANOTECHNOLOGY
COMPOSITE MATERIALS
CURCUMIN
ELECTRON SPIN RESONANCE
FOURIER TRANSFORMATION
HELA CELLS
IN VITRO
INFRARED SPECTRA
METHYLENE BLUE
NANOSTRUCTURES
PVA
SCANNING ELECTRON MICROSCOPY
SEMICONDUCTOR MATERIALS
THERMAL GRAVIMETRIC ANALYSIS
TRANSMISSION ELECTRON MICROSCOPY
VACUUM EVAPORATION
X-RAY DIFFRACTION
ZINC OXIDES