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Title: Lipid raft: A floating island of death or survival

Abstract

Lipid rafts are microdomains of the plasma membrane enriched in cholesterol and sphingolipids, and play an important role in the initiation of many pharmacological agent-induced signaling pathways and toxicological effects. The structure of lipid rafts is dynamic, resulting in an ever-changing content of both lipids and proteins. Cholesterol, as a major component of lipid rafts, is critical for the formation and configuration of lipid raft microdomains, which provide signaling platforms capable of activating both pro-apoptotic and anti-apoptotic signaling pathways. A change of cholesterol level can result in lipid raft disruption and activate or deactivate raft-associated proteins, such as death receptor proteins, protein kinases, and calcium channels. Several anti-cancer drugs are able to suppress growth and induce apoptosis of tumor cells through alteration of lipid raft contents via disrupting lipid raft integrity. -- Highlights: ► The role of lipid rafts in apoptosis ► The pro- and anti-apoptotic effects of lipid raft disruption ► Cancer treatments targeting lipid rafts.

Authors:
 [1];  [1]
  1. Edison Biotechnology Institute and Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701 (United States)
Publication Date:
OSTI Identifier:
22215267
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 259; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; APOPTOSIS; CALCIUM; CHOLESTEROL; DEATH; ISLANDS; LIPIDS; NEOPLASMS; PHOSPHOTRANSFERASES; RECEPTORS; TUMOR CELLS

Citation Formats

George, Kimberly S., Department of Chemistry, Marietta College, Marietta, OH 45750, and Wu, Shiyong. Lipid raft: A floating island of death or survival. United States: N. p., 2012. Web. doi:10.1016/J.TAAP.2012.01.007.
George, Kimberly S., Department of Chemistry, Marietta College, Marietta, OH 45750, & Wu, Shiyong. Lipid raft: A floating island of death or survival. United States. doi:10.1016/J.TAAP.2012.01.007.
George, Kimberly S., Department of Chemistry, Marietta College, Marietta, OH 45750, and Wu, Shiyong. Thu . "Lipid raft: A floating island of death or survival". United States. doi:10.1016/J.TAAP.2012.01.007.
@article{osti_22215267,
title = {Lipid raft: A floating island of death or survival},
author = {George, Kimberly S. and Department of Chemistry, Marietta College, Marietta, OH 45750 and Wu, Shiyong},
abstractNote = {Lipid rafts are microdomains of the plasma membrane enriched in cholesterol and sphingolipids, and play an important role in the initiation of many pharmacological agent-induced signaling pathways and toxicological effects. The structure of lipid rafts is dynamic, resulting in an ever-changing content of both lipids and proteins. Cholesterol, as a major component of lipid rafts, is critical for the formation and configuration of lipid raft microdomains, which provide signaling platforms capable of activating both pro-apoptotic and anti-apoptotic signaling pathways. A change of cholesterol level can result in lipid raft disruption and activate or deactivate raft-associated proteins, such as death receptor proteins, protein kinases, and calcium channels. Several anti-cancer drugs are able to suppress growth and induce apoptosis of tumor cells through alteration of lipid raft contents via disrupting lipid raft integrity. -- Highlights: ► The role of lipid rafts in apoptosis ► The pro- and anti-apoptotic effects of lipid raft disruption ► Cancer treatments targeting lipid rafts.},
doi = {10.1016/J.TAAP.2012.01.007},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 3,
volume = 259,
place = {United States},
year = {2012},
month = {3}
}