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Title: Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis

Abstract

The hedgehog (HH) signaling pathway is a crucial negotiator of developmental proceedings in the embryo governing a diverse array of processes including cell proliferation, differentiation, and tissue patterning. The overall activity of the pathway is significantly curtailed after embryogenesis as well as in adults, yet it retains many of its functional capacities. However, aberration in HH signaling mediates the initiation, proliferation and continued sustenance of malignancy in different tissues to varying degrees through different mechanisms. In this review, we provide an overview of the role of constitutively active aberrant HH signaling pathway in different types of human cancer and the underlying molecular and genetic mechanisms that drive tumorigenesis in that particular tissue. An insight into the various modes of anomalous HH signaling in different organs will provide a comprehensive knowledge of the pathway in these tissues and open a window for individually tailored, tissue-specific therapeutic interventions. The synergistic cross talking of HH pathway with many other regulatory molecules and developmentally inclined signaling pathways may offer many avenues for pharmacological advances. Understanding the molecular basis of abnormal HH signaling in cancer will provide an opportunity to inhibit the deregulated pathway in many aggressive and therapeutically challenging cancers where promising options aremore » not available.« less

Authors:
; ; ; ;  [1];  [1]
  1. Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008 (India)
Publication Date:
OSTI Identifier:
22212599
Resource Type:
Journal Article
Resource Relation:
Journal Name: Experimental Cell Research; Journal Volume: 318; Journal Issue: 16; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; CARCINOMAS; GLIOMAS; GLYCOGEN; GROWTH FACTORS; INSULIN; LUNGS; LYMPHOMAS; NERVE CELLS; PEPTIDES; PROSTATE; RECEPTORS; SKELETON; STEM CELLS; TRANSCRIPTION FACTORS

Citation Formats

Kar, Swayamsiddha, Deb, Moonmoon, Sengupta, Dipta, Shilpi, Arunima, Bhutia, Sujit Kumar, and Patra, Samir Kumar, E-mail: samirp@nitrkl.ac.in. Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis. United States: N. p., 2012. Web. doi:10.1016/J.YEXCR.2012.05.015.
Kar, Swayamsiddha, Deb, Moonmoon, Sengupta, Dipta, Shilpi, Arunima, Bhutia, Sujit Kumar, & Patra, Samir Kumar, E-mail: samirp@nitrkl.ac.in. Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis. United States. doi:10.1016/J.YEXCR.2012.05.015.
Kar, Swayamsiddha, Deb, Moonmoon, Sengupta, Dipta, Shilpi, Arunima, Bhutia, Sujit Kumar, and Patra, Samir Kumar, E-mail: samirp@nitrkl.ac.in. Mon . "Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis". United States. doi:10.1016/J.YEXCR.2012.05.015.
@article{osti_22212599,
title = {Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis},
author = {Kar, Swayamsiddha and Deb, Moonmoon and Sengupta, Dipta and Shilpi, Arunima and Bhutia, Sujit Kumar and Patra, Samir Kumar, E-mail: samirp@nitrkl.ac.in},
abstractNote = {The hedgehog (HH) signaling pathway is a crucial negotiator of developmental proceedings in the embryo governing a diverse array of processes including cell proliferation, differentiation, and tissue patterning. The overall activity of the pathway is significantly curtailed after embryogenesis as well as in adults, yet it retains many of its functional capacities. However, aberration in HH signaling mediates the initiation, proliferation and continued sustenance of malignancy in different tissues to varying degrees through different mechanisms. In this review, we provide an overview of the role of constitutively active aberrant HH signaling pathway in different types of human cancer and the underlying molecular and genetic mechanisms that drive tumorigenesis in that particular tissue. An insight into the various modes of anomalous HH signaling in different organs will provide a comprehensive knowledge of the pathway in these tissues and open a window for individually tailored, tissue-specific therapeutic interventions. The synergistic cross talking of HH pathway with many other regulatory molecules and developmentally inclined signaling pathways may offer many avenues for pharmacological advances. Understanding the molecular basis of abnormal HH signaling in cancer will provide an opportunity to inhibit the deregulated pathway in many aggressive and therapeutically challenging cancers where promising options are not available.},
doi = {10.1016/J.YEXCR.2012.05.015},
journal = {Experimental Cell Research},
number = 16,
volume = 318,
place = {United States},
year = {Mon Oct 01 00:00:00 EDT 2012},
month = {Mon Oct 01 00:00:00 EDT 2012}
}