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Title: CD36 is required for myoblast fusion during myogenic differentiation

Abstract

Highlights: Black-Right-Pointing-Pointer CD36 expression was induced during myogenic differentiation. Black-Right-Pointing-Pointer CD36 expression was localized in multinucleated myotubes. Black-Right-Pointing-Pointer The expression of myogenic markers is attenuated in CD36 knockdown C2C12 cells. Black-Right-Pointing-Pointer Knockdown of CD36 significantly inhibited myotube formation during differentiation. -- Abstract: Recently, CD36 has been found to be involved in the cytokine-induced fusion of macrophage. Myoblast fusion to form multinucleated myotubes is required for myogenesis and muscle regeneration. Because a search of gene expression database revealed the attenuation of CD36 expression in the muscles of muscular dystrophy patients, the possibility that CD36 could be required for myoblast fusion was investigated. CD36 expression was markedly up-regulated during myoblast differentiation and localized in multinucleated myotubes. Knockdown of endogenous CD36 significantly decreased the expression of myogenic markers as well as myotube formation. These results support the notion that CD36 plays an important role in cell fusion during myogenic differentiation. Our finding will aid the elucidation of the common mechanism governing cell-to-cell fusion in various fusion models.

Authors:
 [1];  [2];  [2];  [3]
  1. Department of Biochemistry, College of Medicine, Dongguk University and Medical Institute of Dongguk University, Gyeongju 780-714 (Korea, Republic of)
  2. Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 700-422 (Korea, Republic of)
  3. (Korea, Republic of)
Publication Date:
OSTI Identifier:
22210314
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 427; Journal Issue: 4; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ATTENUATION; GENES; MACROPHAGES; MUSCLES; PATIENTS

Citation Formats

Park, Seung-Yoon, Yun, Youngeun, Kim, In-San, E-mail: iskim@knu.ac.kr, and Biomedical Research Institute, Korea Institute Science and Technology, Seoul. CD36 is required for myoblast fusion during myogenic differentiation. United States: N. p., 2012. Web. doi:10.1016/J.BBRC.2012.09.119.
Park, Seung-Yoon, Yun, Youngeun, Kim, In-San, E-mail: iskim@knu.ac.kr, & Biomedical Research Institute, Korea Institute Science and Technology, Seoul. CD36 is required for myoblast fusion during myogenic differentiation. United States. doi:10.1016/J.BBRC.2012.09.119.
Park, Seung-Yoon, Yun, Youngeun, Kim, In-San, E-mail: iskim@knu.ac.kr, and Biomedical Research Institute, Korea Institute Science and Technology, Seoul. Fri . "CD36 is required for myoblast fusion during myogenic differentiation". United States. doi:10.1016/J.BBRC.2012.09.119.
@article{osti_22210314,
title = {CD36 is required for myoblast fusion during myogenic differentiation},
author = {Park, Seung-Yoon and Yun, Youngeun and Kim, In-San, E-mail: iskim@knu.ac.kr and Biomedical Research Institute, Korea Institute Science and Technology, Seoul},
abstractNote = {Highlights: Black-Right-Pointing-Pointer CD36 expression was induced during myogenic differentiation. Black-Right-Pointing-Pointer CD36 expression was localized in multinucleated myotubes. Black-Right-Pointing-Pointer The expression of myogenic markers is attenuated in CD36 knockdown C2C12 cells. Black-Right-Pointing-Pointer Knockdown of CD36 significantly inhibited myotube formation during differentiation. -- Abstract: Recently, CD36 has been found to be involved in the cytokine-induced fusion of macrophage. Myoblast fusion to form multinucleated myotubes is required for myogenesis and muscle regeneration. Because a search of gene expression database revealed the attenuation of CD36 expression in the muscles of muscular dystrophy patients, the possibility that CD36 could be required for myoblast fusion was investigated. CD36 expression was markedly up-regulated during myoblast differentiation and localized in multinucleated myotubes. Knockdown of endogenous CD36 significantly decreased the expression of myogenic markers as well as myotube formation. These results support the notion that CD36 plays an important role in cell fusion during myogenic differentiation. Our finding will aid the elucidation of the common mechanism governing cell-to-cell fusion in various fusion models.},
doi = {10.1016/J.BBRC.2012.09.119},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 4,
volume = 427,
place = {United States},
year = {2012},
month = {11}
}