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Title: Silibinin attenuates allergic airway inflammation in mice

Abstract

Highlights: Black-Right-Pointing-Pointer Silibinin diminishes ovalbumin-induced inflammatory reactions in the mouse lung. Black-Right-Pointing-Pointer Silibinin reduces the levels of various cytokines into the lung of allergic mice. Black-Right-Pointing-Pointer Silibinin prevents the development of airway hyperresponsiveness in allergic mice. Black-Right-Pointing-Pointer Silibinin suppresses NF-{kappa}B transcriptional activity. -- Abstract: Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-{kappa}B) pathway. Because NF-{kappa}B activation plays a pivotal role in the pathogenesis of allergic inflammation, we have investigated the effect of silibinin on a mouse ovalbumin (OVA)-induced asthma model. Airway hyperresponsiveness, cytokines levels, and eosinophilic infiltration were analyzed in bronchoalveolar lavage fluid and lung tissue. Pretreatment of silibinin significantly inhibited airway inflammatory cell recruitment and peribronchiolar inflammation and reduced the production of various cytokines in bronchoalveolar fluid. In addition, silibinin prevented the development of airway hyperresponsiveness and attenuated the OVA challenge-induced NF-{kappa}B activation. These findings indicate that silibinin protects against OVA-induced airway inflammation, at least in part via downregulation of NF-{kappa}B activity. Our data support the utility of silibinin as a potentialmore » medicine for the treatment of asthma.« less

Authors:
 [1];  [2];  [3];  [4]; ;  [5];  [6];  [5]
  1. Department of Anatomy, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)
  2. Department of Radiology, Yanbian University Hospital, YanJi 133002 (China)
  3. Centralab, The First Affiliated Hospital of Dalian Medical University, Dalian 116011 (China)
  4. Department of Respiratory Medicine, Yanbian University Hospital, YanJi 133000 (China)
  5. Department of Anatomy and Histology and Embryology, Yanbian University School of Basic Medical Sciences, 977 Gongyuan Road, YanJi 133002, Jilin (China)
  6. Department of Pathology, Yanbian University School of Basic Medical Sciences, YanJi 133000 (China)
Publication Date:
OSTI Identifier:
22210301
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 427; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ASTHMA; DRUGS; FLAVONOIDS; INFLAMMATION; LAVAGE; LUNGS; LYMPHOKINES; MICE; MILK; OVA; OVALBUMIN; PATHOGENESIS

Citation Formats

Choi, Yun Ho, Jin, Guang Yu, Guo, Hui Shu, Piao, Hong Mei, Li, Liang chang, Li, Guang Zhao, Lin, Zhen Hua, and Yan, Guang Hai, E-mail: ghyan@ybu.edu.cn. Silibinin attenuates allergic airway inflammation in mice. United States: N. p., 2012. Web. doi:10.1016/J.BBRC.2012.07.112.
Choi, Yun Ho, Jin, Guang Yu, Guo, Hui Shu, Piao, Hong Mei, Li, Liang chang, Li, Guang Zhao, Lin, Zhen Hua, & Yan, Guang Hai, E-mail: ghyan@ybu.edu.cn. Silibinin attenuates allergic airway inflammation in mice. United States. doi:10.1016/J.BBRC.2012.07.112.
Choi, Yun Ho, Jin, Guang Yu, Guo, Hui Shu, Piao, Hong Mei, Li, Liang chang, Li, Guang Zhao, Lin, Zhen Hua, and Yan, Guang Hai, E-mail: ghyan@ybu.edu.cn. Fri . "Silibinin attenuates allergic airway inflammation in mice". United States. doi:10.1016/J.BBRC.2012.07.112.
@article{osti_22210301,
title = {Silibinin attenuates allergic airway inflammation in mice},
author = {Choi, Yun Ho and Jin, Guang Yu and Guo, Hui Shu and Piao, Hong Mei and Li, Liang chang and Li, Guang Zhao and Lin, Zhen Hua and Yan, Guang Hai, E-mail: ghyan@ybu.edu.cn},
abstractNote = {Highlights: Black-Right-Pointing-Pointer Silibinin diminishes ovalbumin-induced inflammatory reactions in the mouse lung. Black-Right-Pointing-Pointer Silibinin reduces the levels of various cytokines into the lung of allergic mice. Black-Right-Pointing-Pointer Silibinin prevents the development of airway hyperresponsiveness in allergic mice. Black-Right-Pointing-Pointer Silibinin suppresses NF-{kappa}B transcriptional activity. -- Abstract: Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-{kappa}B) pathway. Because NF-{kappa}B activation plays a pivotal role in the pathogenesis of allergic inflammation, we have investigated the effect of silibinin on a mouse ovalbumin (OVA)-induced asthma model. Airway hyperresponsiveness, cytokines levels, and eosinophilic infiltration were analyzed in bronchoalveolar lavage fluid and lung tissue. Pretreatment of silibinin significantly inhibited airway inflammatory cell recruitment and peribronchiolar inflammation and reduced the production of various cytokines in bronchoalveolar fluid. In addition, silibinin prevented the development of airway hyperresponsiveness and attenuated the OVA challenge-induced NF-{kappa}B activation. These findings indicate that silibinin protects against OVA-induced airway inflammation, at least in part via downregulation of NF-{kappa}B activity. Our data support the utility of silibinin as a potential medicine for the treatment of asthma.},
doi = {10.1016/J.BBRC.2012.07.112},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 3,
volume = 427,
place = {United States},
year = {2012},
month = {10}
}