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Title: Effects of carboxymethyl chitosan on the blood system of rats

Abstract

Highlights: {yields} We report, for the first time, the safety of carboxymethyl chitosan in blood system. {yields} CM-Chitosan has no significant effects on coagulation function of rats. {yields} CM-Chitosan has no significant effects on anticoagulation performance of rats. {yields} CM-Chitosan has no significant effects on fibrinolytic function of rats. {yields} CM-Chitosan has no significant effects on hemorheology of rats. -- Abstract: Carboxymethyl chitosan (CM-chitosan), a derivative of chitosan, was extensively studied in the biomedical materials field for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CM-chitosan in the blood system are lacking. In this study CM-chitosan was implanted into the abdominal cavity of rats to determine blood indexes at different times and to evaluate the effects of CM-chitosan on the blood system of rats. Coagulation function was reflected by thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4) indexes; anti-coagulation performance was assessed by the index of antithrombinIII (ATIII); fibrinolytic function was reflected by plasminogen (PLG) and fibrin degradation product (FDP) indexes; and blood viscosity (BV) and plasma viscosity (PV) indexes reflected hemorheology. Results showed that CM-chitosan has no significant effects on themore » blood system of rats, and provides experimental basis for CM-chitosan to be applied in the field of biomedical materials.« less

Authors:
 [1];  [1]; ; ; ;  [1]
  1. College of Marine Life Sciences, Ocean University of China, Qingdao 266003 (China)
Publication Date:
OSTI Identifier:
22204897
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 408; Journal Issue: 1; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; AMINO ACIDS; BLOOD; FIBRIN; FIBRINOGEN; HEALING; OLIGOSACCHARIDES; PLASMINOGEN; PROTHROMBIN; RATS; STIMULATION; THROMBIN; VISCOSITY

Citation Formats

Fu, Dawei, Han, Baoqin, Dong, Wen, Yang, Zhao, Lv, You, and Liu, Wanshun. Effects of carboxymethyl chitosan on the blood system of rats. United States: N. p., 2011. Web. doi:10.1016/J.BBRC.2011.03.130.
Fu, Dawei, Han, Baoqin, Dong, Wen, Yang, Zhao, Lv, You, & Liu, Wanshun. Effects of carboxymethyl chitosan on the blood system of rats. United States. https://doi.org/10.1016/J.BBRC.2011.03.130
Fu, Dawei, Han, Baoqin, Dong, Wen, Yang, Zhao, Lv, You, and Liu, Wanshun. Fri . "Effects of carboxymethyl chitosan on the blood system of rats". United States. https://doi.org/10.1016/J.BBRC.2011.03.130.
@article{osti_22204897,
title = {Effects of carboxymethyl chitosan on the blood system of rats},
author = {Fu, Dawei and Han, Baoqin and Dong, Wen and Yang, Zhao and Lv, You and Liu, Wanshun},
abstractNote = {Highlights: {yields} We report, for the first time, the safety of carboxymethyl chitosan in blood system. {yields} CM-Chitosan has no significant effects on coagulation function of rats. {yields} CM-Chitosan has no significant effects on anticoagulation performance of rats. {yields} CM-Chitosan has no significant effects on fibrinolytic function of rats. {yields} CM-Chitosan has no significant effects on hemorheology of rats. -- Abstract: Carboxymethyl chitosan (CM-chitosan), a derivative of chitosan, was extensively studied in the biomedical materials field for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CM-chitosan in the blood system are lacking. In this study CM-chitosan was implanted into the abdominal cavity of rats to determine blood indexes at different times and to evaluate the effects of CM-chitosan on the blood system of rats. Coagulation function was reflected by thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4) indexes; anti-coagulation performance was assessed by the index of antithrombinIII (ATIII); fibrinolytic function was reflected by plasminogen (PLG) and fibrin degradation product (FDP) indexes; and blood viscosity (BV) and plasma viscosity (PV) indexes reflected hemorheology. Results showed that CM-chitosan has no significant effects on the blood system of rats, and provides experimental basis for CM-chitosan to be applied in the field of biomedical materials.},
doi = {10.1016/J.BBRC.2011.03.130},
url = {https://www.osti.gov/biblio/22204897}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 1,
volume = 408,
place = {United States},
year = {2011},
month = {4}
}