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Title: Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells

Abstract

Research highlights: {yields} Salidroside inhibits the growth of human breast cancer cells. {yields} Salidroside induces cell-cycle arrest of human breast cancer cells. {yields} Salidroside induces apoptosis of human breast cancer cell lines. -- Abstract: Recently, salidroside (p-hydroxyphenethyl-{beta}-D-glucoside) has been identified as one of the most potent compounds isolated from plants of the Rhodiola genus used widely in traditional Chinese medicine, but pharmacokinetic data on the compound are unavailable. We were the first to report the cytotoxic effects of salidroside on cancer cell lines derived from different tissues, and we found that human breast cancer MDA-MB-231 cells (estrogen receptor negative) were sensitive to the inhibitory action of low-concentration salidroside. To further investigate the cytotoxic effects of salidroside on breast cancer cells and reveal possible ER-related differences in response to salidroside, we used MDA-MB-231 cells and MCF-7 cells (estrogen receptor-positive) as models to study possible molecular mechanisms; we evaluated the effects of salidroside on cell growth characteristics, such as proliferation, cell cycle duration, and apoptosis, and on the expression of apoptosis-related molecules. Our results demonstrated for the first time that salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells and may be a promising candidate for breast cancer treatment.

Authors:
 [1];  [2];  [1]; ;  [3]
  1. Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou (China)
  2. The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou (China)
  3. Fourth Military Medical University, Xi'an (China)
Publication Date:
OSTI Identifier:
22202692
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 398; Journal Issue: 1; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CONCENTRATION RATIO; DRUGS; ESTROGENS; HUMAN POPULATIONS; MAMMARY GLANDS; MEDICINE; NEOPLASMS; RECEPTORS

Citation Formats

Hu, Xiaolan, E-mail: huxiaolan1998@yahoo.com.cn, Zhang, Xianqi, Qiu, Shuifeng, Yu, Daihua, and Lin, Shuxin. Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. United States: N. p., 2010. Web. doi:10.1016/J.BBRC.2010.06.033.
Hu, Xiaolan, E-mail: huxiaolan1998@yahoo.com.cn, Zhang, Xianqi, Qiu, Shuifeng, Yu, Daihua, & Lin, Shuxin. Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. United States. doi:10.1016/J.BBRC.2010.06.033.
Hu, Xiaolan, E-mail: huxiaolan1998@yahoo.com.cn, Zhang, Xianqi, Qiu, Shuifeng, Yu, Daihua, and Lin, Shuxin. Fri . "Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells". United States. doi:10.1016/J.BBRC.2010.06.033.
@article{osti_22202692,
title = {Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells},
author = {Hu, Xiaolan, E-mail: huxiaolan1998@yahoo.com.cn and Zhang, Xianqi and Qiu, Shuifeng and Yu, Daihua and Lin, Shuxin},
abstractNote = {Research highlights: {yields} Salidroside inhibits the growth of human breast cancer cells. {yields} Salidroside induces cell-cycle arrest of human breast cancer cells. {yields} Salidroside induces apoptosis of human breast cancer cell lines. -- Abstract: Recently, salidroside (p-hydroxyphenethyl-{beta}-D-glucoside) has been identified as one of the most potent compounds isolated from plants of the Rhodiola genus used widely in traditional Chinese medicine, but pharmacokinetic data on the compound are unavailable. We were the first to report the cytotoxic effects of salidroside on cancer cell lines derived from different tissues, and we found that human breast cancer MDA-MB-231 cells (estrogen receptor negative) were sensitive to the inhibitory action of low-concentration salidroside. To further investigate the cytotoxic effects of salidroside on breast cancer cells and reveal possible ER-related differences in response to salidroside, we used MDA-MB-231 cells and MCF-7 cells (estrogen receptor-positive) as models to study possible molecular mechanisms; we evaluated the effects of salidroside on cell growth characteristics, such as proliferation, cell cycle duration, and apoptosis, and on the expression of apoptosis-related molecules. Our results demonstrated for the first time that salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells and may be a promising candidate for breast cancer treatment.},
doi = {10.1016/J.BBRC.2010.06.033},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 1,
volume = 398,
place = {United States},
year = {2010},
month = {7}
}