Bifurcate effects of glucose on caspase-independent cell death during hypoxia
Abstract
We investigated the effect of glucose on hypoxic death of rat cardiomyocyte-derived H9c2 cells and found that there is an optimal glucose concentration for protection against hypoxic cell death. Hypoxic cell death in the absence of glucose is accompanied by rapid ATP depletion, release of apoptosis-inducing factor from mitochondria, and nuclear chromatin condensation, all of which are inhibited by glucose in a dose-dependent manner. In contrast, excessive glucose also induces hypoxic cell death that is not accompanied by these events, suggesting a change in the mode of cell death between hypoxic cells with and without glucose supplementation.
- Authors:
-
- Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 (Japan)
- Publication Date:
- OSTI Identifier:
- 22202631
- Resource Type:
- Journal Article
- Journal Name:
- Biochemical and Biophysical Research Communications
- Additional Journal Information:
- Journal Volume: 396; Journal Issue: 3; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; ADP; ANOXIA; APOPTOSIS; ATP; CHROMATIN; CONCENTRATION RATIO; DEATH; FLUORESCENCE; GLUCOSE; LACTATE DEHYDROGENASE; MITOCHONDRIA; RATS; RIBOSE
Citation Formats
Aki, Toshihiko, Nara, Akina, Funakoshi, Takeshi, and Uemura, Koichi. Bifurcate effects of glucose on caspase-independent cell death during hypoxia. United States: N. p., 2010.
Web. doi:10.1016/J.BBRC.2010.04.122.
Aki, Toshihiko, Nara, Akina, Funakoshi, Takeshi, & Uemura, Koichi. Bifurcate effects of glucose on caspase-independent cell death during hypoxia. United States. https://doi.org/10.1016/J.BBRC.2010.04.122
Aki, Toshihiko, Nara, Akina, Funakoshi, Takeshi, and Uemura, Koichi. 2010.
"Bifurcate effects of glucose on caspase-independent cell death during hypoxia". United States. https://doi.org/10.1016/J.BBRC.2010.04.122.
@article{osti_22202631,
title = {Bifurcate effects of glucose on caspase-independent cell death during hypoxia},
author = {Aki, Toshihiko and Nara, Akina and Funakoshi, Takeshi and Uemura, Koichi},
abstractNote = {We investigated the effect of glucose on hypoxic death of rat cardiomyocyte-derived H9c2 cells and found that there is an optimal glucose concentration for protection against hypoxic cell death. Hypoxic cell death in the absence of glucose is accompanied by rapid ATP depletion, release of apoptosis-inducing factor from mitochondria, and nuclear chromatin condensation, all of which are inhibited by glucose in a dose-dependent manner. In contrast, excessive glucose also induces hypoxic cell death that is not accompanied by these events, suggesting a change in the mode of cell death between hypoxic cells with and without glucose supplementation.},
doi = {10.1016/J.BBRC.2010.04.122},
url = {https://www.osti.gov/biblio/22202631},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 3,
volume = 396,
place = {United States},
year = {Fri Jun 04 00:00:00 EDT 2010},
month = {Fri Jun 04 00:00:00 EDT 2010}
}
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