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Title: Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method

Abstract

Quantum dots (QDs) are rapidly emerging as an important class of nanoparticles (NPs) with potential applications in medicine. However, little is known about penetration of QDs through human skin. This study investigated skin penetration of QDs in both in vivo and in vitro human skin. Using the tape stripping method, this study demonstrates for the first time that QDs can actually penetrate through the stratum corneum (SC) of human skin. Transmission electron microscope (TEM) and energy diverse X-ray (EDX) analysis showed accumulation of QDs in the SC of a human skin equivalent model (HSEM) after dermal exposure to QDs. These findings suggest possible transdermal absorption of QDs after dermal exposure over a relatively long period of time.

Authors:
; ;  [1]; ; ; ;  [2];  [3]
  1. Laboratory of Cell Signaling and Nanomedicine, Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science, Korea University College of Medicine, Seoul (Korea, Republic of)
  2. National Institute of Toxicological Research, Seoul (Korea, Republic of)
  3. Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
OSTI Identifier:
22202459
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 394; Journal Issue: 3; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ABSORPTION; IN VITRO; IN VIVO; QUANTUM DOTS; SKIN; STRIPPING; TRANSMISSION ELECTRON MICROSCOPY; X RADIATION

Citation Formats

Jeong, Sang Hoon, Kim, Jae Hwan, Yi, Sang Min, Lee, Jung Pyo, Kim, Jin Ho, Sohn, Kyung Hee, Park, Kui Lea, Kim, Meyoung-Kon, and Son, Sang Wook, E-mail: skin4u@korea.ac.kr. Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method. United States: N. p., 2010. Web. doi:10.1016/J.BBRC.2010.03.032.
Jeong, Sang Hoon, Kim, Jae Hwan, Yi, Sang Min, Lee, Jung Pyo, Kim, Jin Ho, Sohn, Kyung Hee, Park, Kui Lea, Kim, Meyoung-Kon, & Son, Sang Wook, E-mail: skin4u@korea.ac.kr. Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method. United States. https://doi.org/10.1016/J.BBRC.2010.03.032
Jeong, Sang Hoon, Kim, Jae Hwan, Yi, Sang Min, Lee, Jung Pyo, Kim, Jin Ho, Sohn, Kyung Hee, Park, Kui Lea, Kim, Meyoung-Kon, and Son, Sang Wook, E-mail: skin4u@korea.ac.kr. 2010. "Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method". United States. https://doi.org/10.1016/J.BBRC.2010.03.032.
@article{osti_22202459,
title = {Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method},
author = {Jeong, Sang Hoon and Kim, Jae Hwan and Yi, Sang Min and Lee, Jung Pyo and Kim, Jin Ho and Sohn, Kyung Hee and Park, Kui Lea and Kim, Meyoung-Kon and Son, Sang Wook, E-mail: skin4u@korea.ac.kr},
abstractNote = {Quantum dots (QDs) are rapidly emerging as an important class of nanoparticles (NPs) with potential applications in medicine. However, little is known about penetration of QDs through human skin. This study investigated skin penetration of QDs in both in vivo and in vitro human skin. Using the tape stripping method, this study demonstrates for the first time that QDs can actually penetrate through the stratum corneum (SC) of human skin. Transmission electron microscope (TEM) and energy diverse X-ray (EDX) analysis showed accumulation of QDs in the SC of a human skin equivalent model (HSEM) after dermal exposure to QDs. These findings suggest possible transdermal absorption of QDs after dermal exposure over a relatively long period of time.},
doi = {10.1016/J.BBRC.2010.03.032},
url = {https://www.osti.gov/biblio/22202459}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 3,
volume = 394,
place = {United States},
year = {Fri Apr 09 00:00:00 EDT 2010},
month = {Fri Apr 09 00:00:00 EDT 2010}
}