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Title: Endothelial cells promote the proliferation of lymphocytes partly through the Wnt pathway via LEF-1

Abstract

The function of T cells and B cells is to recognize specific 'non-self' antigens, during a process known as antigen presentation. Once they have identified an invader, the cells generate specific responses that are tailored to maximally eliminate specific pathogens or pathogen-infected cells. Endothelial cells (ECs) can trigger the activation of T cells through their class I and class II MHC molecules. In this study, we examined the effect of ECs on the proliferation of lymphocytes. We report that the proliferation of T and B cells can be improved by interaction with ECs. LEF-1 is one of the main molecular mediators in this process, and the inhibition of LEF-1 induces apoptosis. These results suggest that LEF-1 modulates positively the proliferation of lymphocytes induced by their interaction with ECs.

Authors:
 [1];  [1];  [2]
  1. Department of Medical Oncology, The First Affiliated Hospital of The School of Medicine of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province (China)
  2. Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xian 710032, Shaanxi Province (China)
Publication Date:
OSTI Identifier:
22199824
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 388; Journal Issue: 1; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIGENS; APOPTOSIS; BIOLOGICAL FUNCTIONS; CELL PROLIFERATION; INHIBITION; LYMPHOCYTES; MOLECULES; PATHOGENS

Citation Formats

Wang, Shu-Hong, Nan, Ke-Jun, E-mail: nankj@163.com, and Wang, Yao-Chun. Endothelial cells promote the proliferation of lymphocytes partly through the Wnt pathway via LEF-1. United States: N. p., 2009. Web. doi:10.1016/J.BBRC.2009.07.117.
Wang, Shu-Hong, Nan, Ke-Jun, E-mail: nankj@163.com, & Wang, Yao-Chun. Endothelial cells promote the proliferation of lymphocytes partly through the Wnt pathway via LEF-1. United States. doi:10.1016/J.BBRC.2009.07.117.
Wang, Shu-Hong, Nan, Ke-Jun, E-mail: nankj@163.com, and Wang, Yao-Chun. Fri . "Endothelial cells promote the proliferation of lymphocytes partly through the Wnt pathway via LEF-1". United States. doi:10.1016/J.BBRC.2009.07.117.
@article{osti_22199824,
title = {Endothelial cells promote the proliferation of lymphocytes partly through the Wnt pathway via LEF-1},
author = {Wang, Shu-Hong and Nan, Ke-Jun, E-mail: nankj@163.com and Wang, Yao-Chun},
abstractNote = {The function of T cells and B cells is to recognize specific 'non-self' antigens, during a process known as antigen presentation. Once they have identified an invader, the cells generate specific responses that are tailored to maximally eliminate specific pathogens or pathogen-infected cells. Endothelial cells (ECs) can trigger the activation of T cells through their class I and class II MHC molecules. In this study, we examined the effect of ECs on the proliferation of lymphocytes. We report that the proliferation of T and B cells can be improved by interaction with ECs. LEF-1 is one of the main molecular mediators in this process, and the inhibition of LEF-1 induces apoptosis. These results suggest that LEF-1 modulates positively the proliferation of lymphocytes induced by their interaction with ECs.},
doi = {10.1016/J.BBRC.2009.07.117},
journal = {Biochemical and Biophysical Research Communications},
number = 1,
volume = 388,
place = {United States},
year = {Fri Oct 09 00:00:00 EDT 2009},
month = {Fri Oct 09 00:00:00 EDT 2009}
}